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Anti-cancer immunotherapy could be used to fight HIV

Researchers at the University of Montreal Hospital Research Centre have shown that immunotherapy treatments against cancer could reduce the amount of virus that persists in people on triple therapy.

19 Feb 2019

Gene therapy restores hearing in mice with congenital genetic deafness

In collaboration with the universities of Miami, Columbia and San Francisco, scientists from the Institut Pasteur, Inserm, CNRS, Collège de France, Sorbonne University and the University of Clermont Auvergne have managed to restore hearing in an adult mouse model of DFNB9 deafness - a hearing disorder that represents one of the most frequent cases of congenital genetic deafness.

19 Feb 2019

Researchers create new map of the brain's own immune system

A team of researchers under the direction of the Medical Center - University of Freiburg has created an entirely new map of the brain's own immune system in humans and mice.

19 Feb 2019

Specialized lung cells appear in the developing fetus much earlier than previously thought

Specialized lung cells appear in the developing fetus much earlier than scientists previously thought. A new animal study reports how cells that become alveoli, the tiny compartments in which gas exchange occurs in the lung, begin their specialized roles very early in prenatal life.

19 Feb 2019

New study establishes how stress favors breast cancer growth and spread

Cancer: The word alone evokes dread, anxiety, and fear. Accordingly, many women living with the disease and undergoing treatment experience chronic stress and depression.

19 Feb 2019

Study shows how 3D organization of genetic material helps perpetuate the species

From fathers to children, the delivery of hereditary information requires the careful packing of DNA in sperm. But just how nature packages this DNA to prepare offspring isn't clear.

19 Feb 2019

Harnessing the evolutionary games played by cancer cells to advance therapies

Despite rapid advances in targeted therapies for cancer, tumors commonly develop resistance to treatment. When resistance emerges, tumor cells continue to grow unchecked, despite all attempts to slow cancer progression.

19 Feb 2019

Fetal signaling pathways may offer future opportunities to treat lung damage

Specialized lung cells appear in the developing fetus much earlier than scientists previously thought. A new animal study published this week in the Proceedings of the National Academy of Sciences reports how cells that become alveoli, the tiny compartments in which gas exchange occurs in the lung, begin their specialized roles very early in prenatal life.

18 Feb 2019

Study finds neuromelanin-sensitive MRI as potential biomarker for psychosis

Researchers have shown that a type of magnetic resonance imaging -- called neuromelanin-sensitive MRI is a potential biomarker for psychosis.

18 Feb 2019

Researchers identify suicide toxin in the bacteria responsible for tuberculosis

The bacteria responsible for tuberculosis can be killed by a toxin they produce unless it is neutralized by an antidote protein. The European team of scientists behind this discovery is coordinated by researchers from the Institute of Pharmacology and Structural Biology and the European Molecular Biology Laboratory.

18 Feb 2019

Single CRISPR treatment can safely and stably correct genetic disease

Researchers at Duke University have shown that a single systemic treatment using CRISPR genome editing technology can safely and stably correct a genetic disease -- Duchenne muscular dystrophy (DMD) -- for more than a year in mice, despite observed immune responses and alternative gene editing outcomes.

18 Feb 2019

New protocol could help physicians to rule out bacterial infections in infants

A new protocol could help emergency room physicians to rule out life-threatening bacterial infections among infants up to 2 months of age who have fevers, potentially eliminating the need for spinal taps, unnecessary antibiotic treatments or expensive hospital stays.

18 Feb 2019

Using light-based method for production of pharmaceutical molecules

Photoelectrochemical cells are widely studied for the conversion of solar energy into chemical fuels. They use photocathodes and photoanodes to "split" water into hydrogen and oxygen respectively.

18 Feb 2019

CRISPR technology creates pluripotent stem cells that are 'invisible' to the immune system

UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally "invisible" to the immune system, a feat of biological engineering that, in laboratory studies, prevented rejection of stem cell transplants.

18 Feb 2019

Scientists discover trigger that turns strep infections into devastating disease

Houston Methodist infectious disease scientists have discovered a previously unknown trigger that turns a relatively run-of-the-mill infection into a devastatingly ravenous, flesh-eating disease.

18 Feb 2019

Physicists identify simple mechanism used by deadly bacteria to fend off antibiotics

Physicists at McMaster University have for the first time identified a simple mechanism used by potentially deadly bacteria to fend off antibiotics, a discovery which is providing new insights into how germs adapt and behave at a level of detail never seen before.

18 Feb 2019

Customizing the Cellular Microenvironment to Improve Physiological Relevance

An interview with Marie-Charlotte Manus, discussing a new technology called PRIMO that improves the physiological relevance of cells in culture.

From Alveole 18 Feb 2019

Combination of PARP inhibitor and immunotherapy results in tumor regression in SCLC mouse models

Researchers at The University of Texas MD Anderson Cancer Center have discovered that a combination of immune checkpoint blockade and targeted therapies that block normal DNA damage repair achieved significant tumor regression in mouse models of small cell lung cancer, suggesting a promising new approach for treating patients with this aggressive cancer.

18 Feb 2019

Activating gene that helps excite neurons reverses depression in male mice

Directly activating a gene important to exciting our excitatory neurons and associated with major depression may help turn around classic symptoms like social isolation and loss of interest, at least for males, scientists report.

18 Feb 2019

Drug combinations could become first-line treatment for metastatic kidney cancer

A combination of two drugs - one of them an immunotherapy agent - could become a new standard, first-line treatment for patients with metastatic kidney cancer, says an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.

18 Feb 2019