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Research team describes how the brain controls whisker movements in mice

All parents know the infant milestones: turning over, learning to crawl, standing, and taking that first unassisted step. Achieving each accomplishment presumably requires the formation of new connections among subsets of the billions of nerve cells in the infant's brain. But how, when and where those connections form has been a mystery.

24 Jan 2013

Salk Institute to establish Helmsley Center for Genomic Medicine

The Salk Institute for Biological Studies has received a $42 million gift-the largest in the Institute's history-to establish the Helmsley Center for Genomic Medicine (HCGM), a research center dedicated to decoding the common genetic factors underlying many complex chronic human diseases.

23 Jan 2013

SLU team discovers molecular pathway that contributes to triple-negative breast cancer

In research published in the Jan. 17 issue of The Journal of Cell Biology, a team led by Susana Gonzalo, Ph.D., assistant professor of biochemistry and molecular biology at Saint Louis University, has discovered a molecular pathway that contributes to triple-negative breast cancer, an often deadly and treatment resistant form of cancer that tends to strike younger women.

23 Jan 2013

Brown biology professor named Pew's Scholar of the Month

Biologist Erica Larschan, Ph.D., was named by The Pew Charitable Trusts as the "Scholar of the Month," for her innovative findings on chromosomal activity in fruit flies.

22 Jan 2013

Neuronal reprogramming may help treat neurodegenerative diseases

A new finding by Harvard stem cell biologists turns one of the basics of neurobiology on its head - demonstrating that it is possible to turn one type of already differentiated neuron into another within the brain.

22 Jan 2013

BRCA1-deficient cancer cells take advantage of DNA repair mechanism

Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing themselves from stagnation or death. The study appears in the January 21st issue of The Journal of Cell Biology.

22 Jan 2013

New details about molecular surveillance system that helps detect and correct errors in cell division

Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.

21 Jan 2013

Flu virus can essentially tell time: Research

Scientists have discovered that that the flu virus can essentially tell time, thereby giving scientists the ability to reset the virus' clock and combat it in more effective ways. According to researchers at the Icahn School of Medicine at Mount Sinai, the flu knows how much time it has to multiply, infect other cells, and spread to another human being. If it leaves a cell too soon, the virus is too weak. If it leaves too late, the immune system has time to kill the virus.

18 Jan 2013

UCI study identifies transgenerational effects of tributyltin

Exposing pregnant mice to low doses of the chemical tributyltin - which is used in marine hull paint and PVC plastic - can lead to obesity for multiple generations without subsequent exposure, a UC Irvine study has found.

17 Jan 2013

Simple and inexpensive method to cut DNA could transform genetic medicine

A simple, precise and inexpensive method for cutting DNA to insert genes into human cells could transform genetic medicine, making routine what now are expensive, complicated and rare procedures for replacing defective genes in order to fix genetic disease or even cure AIDS.

10 Jan 2013

Minor mutations can lead to big improvements in antibiotic resistance

Rice University scientists have found that mutations of small effect can turn out to be game changers in the bacterial fight against antibiotic drugs.

10 Jan 2013

Paper provides comprehensive assessment of motor performance after cervical spinal cord injury

More than half of traumatic spinal cord injuries (SCI) in humans are cervical lesions, resulting in chronic loss of limb function. A better understanding of the link between the neurologic damage caused by SCI, spontaneous motor function recovery, and long-term motor deficits would lead to better therapeutic approaches, as discussed in an article in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The

4 Jan 2013

MBL Physiology course has a positive 'real research' impact on students

What happens when graduate students in biology are given the freedom to play, dabble in new fields, launch into the unknowns of genuine research, not worry about getting "good" results?

29 Dec 2012

New light on how epigenetic signals may function together to determine fate of stem cell

Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.

28 Dec 2012

New light on genome replication

New York University biologists have identified how a vital protein is loaded by others into the centromere, the part of the chromosome that plays a significant role in cell division. Their findings shed new light on genome replication and may offer insights into the factors behind the production of abnormal numbers of chromosomes.

25 Dec 2012

Scientists sequence complete genome of leeches

Leeches, despite the yuck factor, have captured the hearts of two University of California, Berkeley, scientists who are part of a team that this week is publishing the leech's complete genome sequence.

21 Dec 2012

Novel virus-based gene therapy holds promise for Canavan disease

Research led by Paola Leone, PhD, of the University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine (UMDNJ-SOM), demonstrates the long term safety and benefit of a virus-based gene therapy that has been applied for the first time in a clinical setting.

21 Dec 2012

New work on Akt's role in cancer stem cell biology

The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death. New work on Akt's role in cancer stem cell biology from the lab of senior author Honglin Zhou, MD, PhD and Weihua Li, co-first author, both from the Center for Resuscitation Sciences, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, and Xiaowei Xu, Department of Pathology and Laboratory Medicine, appears in Molecular Cell.

21 Dec 2012

Two recent experimental treatments improve visual function in mouse models of retinitis pigmentosa

Two recent experimental treatments - one involving skin-derived induced pluripotent stem (iPS) cell grafts, the other gene therapy - have been shown to produce long-term improvement in visual function in mouse models of retinitis pigmentosa (RP), according to the Columbia University Medical Center (CUMC) scientists who led the studies. At present, there is no cure for RP, the most common form of inherited blindness.

20 Dec 2012

AAV-based gene therapy cocktail may help extend lives of children with Canavan disease

Results of a clinical trial that began in 2001 show that a gene therapy cocktail conveyed into the brain by a molecular special delivery vehicle may help extend the lives of children with Canavan disease, a rare and fatal neurodegenerative disorder.

20 Dec 2012

Cell Biology News and Research

Research team describes how the brain controls whisker movements in mice

Salk Institute to establish Helmsley Center for Genomic Medicine

SLU team discovers molecular pathway that contributes to triple-negative breast cancer

Brown biology professor named Pew's Scholar of the Month

Neuronal reprogramming may help treat neurodegenerative diseases

BRCA1-deficient cancer cells take advantage of DNA repair mechanism

New details about molecular surveillance system that helps detect and correct errors in cell division

Flu virus can essentially tell time: Research

UCI study identifies transgenerational effects of tributyltin

Simple and inexpensive method to cut DNA could transform genetic medicine

Minor mutations can lead to big improvements in antibiotic resistance

Paper provides comprehensive assessment of motor performance after cervical spinal cord injury

MBL Physiology course has a positive 'real research' impact on students

New light on how epigenetic signals may function together to determine fate of stem cell

New light on genome replication

Scientists sequence complete genome of leeches

Novel virus-based gene therapy holds promise for Canavan disease

New work on Akt's role in cancer stem cell biology

Two recent experimental treatments improve visual function in mouse models of retinitis pigmentosa

AAV-based gene therapy cocktail may help extend lives of children with Canavan disease

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