Mouse Model News and Research

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Synthetic DNA vaccine targets proteins overexpressed in several types of cancer

Scientists at The Wistar Institute have implemented a novel structurally designed synthetic DNA vaccine to simultaneously target multiple members of a family of proteins that are specifically overexpressed in several types of cancer.

28 Sep 2018

Not all P53 mutations cause skin cancer

Today, scientists have explained for the first time why not all UV-induced, P53 mutated skin cells develop into cancer.

27 Sep 2018

Olfactory cells could act as 'Trojan horse,' delivering anticancer therapy to dangerous brain tumors

A special type of cell essential to the ability of olfactory neurons to regenerate may be genetically engineered to deliver anticancer therapy to the dangerous brain tumors called glioblastomas.

27 Sep 2018

Researchers uncover molecular underpinnings of liver regeneration

In Greek mythology, Zeus punishes the trickster Prometheus by chaining him to a rock and sending an eagle to eat a portion of his liver every day, in perpetuity. It was the right organ to target - the liver has the ability to regenerate itself, though not overnight nor for eternity.

27 Sep 2018

Novel drug alleviates memory deficits and neuropathology in Alzheimer's animal model

New research conducted at the Lady Davis Institute at the Jewish General Hospital reveals that a novel drug reverses memory deficits and stops Alzheimer disease pathology in an animal model.

25 Sep 2018

UC Davis researchers take critical step in developing more effective Salmonella vaccine

UC Davis researchers announce in the Proceedings of the National Academy of Sciences this week a breakthrough in understanding which cells afford optimal protection against Salmonella infection--a critical step in developing a more effective and safe vaccine against a bacterium that annually kills an estimated one million people worldwide.

25 Sep 2018

Gene therapy approach could help treat mitochondrial diseases

Researchers have developed a genome-editing tool for the potential treatment of mitochondrial diseases: serious and often fatal conditions which affect 1 in 5,000 people.

24 Sep 2018

Researchers highlight potential therapy for treating rare, deadly blood-clotting disorder

In proof-of-concept experiments, University of Alabama at Birmingham researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP.

24 Sep 2018

Researchers identify new genetic disorder in a human patient

Researchers from Michigan State University College of Human Medicine and physicians from Spectrum Health have identified for the first time in a human patient a genetic disorder only previously described in animal models.

21 Sep 2018

Scientists use mice to study transmission of Lyme disease bacteria by infected ticks

Lyme borreliosis is a disease caused by bacteria of the genus Borrelia that are transmitted by a bite from a tick of the genus Ixodes.

21 Sep 2018

Study shows how the drive to eat overpowers the brain’s signal to stop

University of Michigan researchers have studied two groups of brain cells that compete for the control of feeding behaviour and found that cells that drive the urge to eat overpower the ones that signal to stop.

21 Sep 2018

Antioxidant in green tea helps sneak therapeutic RNAs into cells

Drinking green tea has been linked to health benefits ranging from cardiovascular disease prevention to weight loss.

19 Sep 2018

Microbiota in the intestines and cell stress cause colon cancer

"With our study we originally wanted to study the role of bacteria in the intestines in the development of intestinal inflammation," explains Professor Dirk Haller from the Department of Nutrition and Immunology at the Weihenstephan Science Centre of the TUM.

18 Sep 2018

Zika virus vaccine shows promise for treatment of fatal glioblastoma

An international team of researchers has successfully deployed a Zika virus vaccine to target and kill human glioblastoma brain cancer stem cells, which had been transplanted into mice.

18 Sep 2018

New studies examine links between fatty liver disease and mitochondrial dysfunction

Researchers at Northeast Ohio Medical University studied the lifespan of mitochondrial proteins in a mouse model of fatty liver disease. Comparing the amount of protein between healthy mice and a mouse model of nonalcoholic fatty liver disease gave them an estimate of each protein's half-life.

17 Sep 2018

Mouse Model News and Research

Synthetic DNA vaccine targets proteins overexpressed in several types of cancer

Not all P53 mutations cause skin cancer

Olfactory cells could act as 'Trojan horse,' delivering anticancer therapy to dangerous brain tumors

Researchers uncover molecular underpinnings of liver regeneration

Novel drug alleviates memory deficits and neuropathology in Alzheimer's animal model

UC Davis researchers take critical step in developing more effective Salmonella vaccine

Gene therapy approach could help treat mitochondrial diseases

Researchers highlight potential therapy for treating rare, deadly blood-clotting disorder

Researchers identify new genetic disorder in a human patient

Scientists use mice to study transmission of Lyme disease bacteria by infected ticks

Study shows how the drive to eat overpowers the brain’s signal to stop

Antioxidant in green tea helps sneak therapeutic RNAs into cells

Microbiota in the intestines and cell stress cause colon cancer

Zika virus vaccine shows promise for treatment of fatal glioblastoma

New studies examine links between fatty liver disease and mitochondrial dysfunction

Investigators pinpoint exact stage of retinoblastoma development in children

How 'bad' bacteria gain an upper hand in the human gut

Gene involved in circadian rhythms can be potential target for glioblastoma treatment

New study aims to understand why skin grafts have high rate of rejection

Researchers program open wound cells to turn into healthy skin

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