Genetic News and Research

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Transgenomic to present study results of high-sensitivity cancer mutation assays at AACR

Transgenomic, Inc. announced today that its scientists have completed studies employing the company's high-sensitivity cancer mutation assays using two proprietary technologies, Ice COLD-PCR and BLOCker-Sequencing. Results from these studies will be presented at the American Association for Cancer Research meeting in Orlando, Florida, April 2-6, 2011.

2 Apr 2011

Series of new clinical trials confirm range of viable treatment options for HCV patients

Highly anticipated data from a number of clinical trials presented for the first time at the International Liver CongressTM confirmed that a range of new proteases inhibitors will help treat patients who have previously failed therapy for the treatment of chronic hepatitis C.

2 Apr 2011

Rsearchers define new step that controls programmed cell death in cancer cells

When cells find themselves in a tight spot, the cell cycle regulator p21 halts the cell cycle, buying cells time to repair the damage, or if all else fails, to initiate programmed cell death.

2 Apr 2011

Loss of SKIP sensitizes cancer cells to apoptotic effects of DNA damage-inducing anticancer drugs

When cells find themselves in a tight spot, the cell cycle regulator p21 halts the cell cycle, buying cells time to repair the damage, or if all else fails, to initiate programmed cell death. In contrast to other stress-induced genes, which dispense with the regular transcriptional entourage, p21Cip1 still requires SKIP, a transcription elongation factor that also helps with the editing of transcripts, to be expressed, found researchers at the Salk Institute for Biological Studies.

2 Apr 2011

LCA calls for comprehensive plan of action to reduce lung cancer mortality

Lung Cancer Alliance called again today for a comprehensive plan of action that will make reducing lung cancer mortality a public health priority.

2 Apr 2011

Study: MicroRNA can predict risk of BM in lung cancer patients

Conducting genetic profiles using microRNA can help doctors predict which lung cancer patients are likely to also develop brain metastasis, according to a study published today by Scottsdale Healthcare and the Translational Genomics Research Institute.

1 Apr 2011

Biocept, academic collaborators' posters on CTCs to be presented at AACR meeting

Biocept, Inc. today reported that its scientists and academic collaborators will present four posters at the 102nd Annual Meeting of the American Association for Cancer Research taking place in Orlando, Florida April 2-6, 2011.

1 Apr 2011

NAMI launches new schizophrenia website and brochure

The National Alliance on Mental Illness has launched a new website on schizophrenia and published a new brochure on the medical condition which affects more than 2.4 million American adults each year.

1 Apr 2011

Early recognition and treatment can control obsessive-compulsive manifestation

Obsessive-compulsive disorder is often diagnosed too late in children and adolescents. In the current issue of Deutsches Ärzteblatt International, Susanne Walitza and her colleagues point out that appropriate early recognition and treatment can positively affect the course of the disease.

1 Apr 2011

Study shows immune therapy can prevent pregnancy in mammals including humans

Researchers at Weill Cornell Medical College have shown that it is possible to immunize mammals to control fertility. They say their technique could possibly be used on other mammals -- including humans -- because fertility hormones and their receptors are species-non-specific and are similar in both females and males.

1 Apr 2011

New research finds HIV virus's V3 loop as attractive vaccine target

A section of the AIDS virus's protein envelope once considered an improbable target for a vaccine now appears to be one of the most promising, new research by Dana-Farber Cancer Institute scientists indicates.

1 Apr 2011

Study: Pseudokinases can play a crucial role in pathogen-based disease

Researchers from the University of Pittsburgh and Stanford University discovered that a supposedly inactive protein actually plays a crucial role in the ability of one the world's most prolific pathogens to cause disease, findings that suggest the possible role of similarly errant proteins in other diseases.

1 Apr 2011

Study confirms D-penicillamine and trientine effective against Wilson disease

Results from the first ever European-wide retrospective analysis presented today at the International Liver CongressTM have shown both D-penicillamine and trientine continue to be effective treatments, providing positive survival rates in patients with Wilson disease free from a liver transplant.

1 Apr 2011

Merck's VICTRELIS phase III study results against HCV presented at EASL annual meeting

Merck, known as MSD outside of the United States and Canada, announced results from several new data analyses from the pivotal Phase III studies evaluating the addition of its investigational oral protease inhibitor VICTRELIS to peginterferon alfa-2b and ribavirin in adult patients with chronic hepatitis C virus genotype 1 infection.

1 Apr 2011

DNA damage can lead to regulation of inflammatory responses

Researchers offer the first evidence that DNA damage can lead to the regulation of inflammatory responses, the body's reaction to injury. The proteins involved in the regulation help protect the body from infection.

1 Apr 2011

Conatus CTS-1027 Phase 2 trial results against HCV presented at EASL meeting

Conatus Pharmaceuticals Inc. announced today 24-week interim results from a clinical trial with CTS-1027 in combination with Peginterferon Alpha-2a and ribavirin in a treatment experienced, hepatitis C virus null-responder patient population.

1 Apr 2011

Mitochondrial defect inherited from mother is linked to high blood pressure in one Chinese family

A specific genetic defect in one Chinese family shows that high blood pressure was inherited from the female parent, researchers report in Circulation Research: Journal of the American Heart Association.

1 Apr 2011

Sequential treatment with Entecavir and Lamivudine results in rebound of hepatitis B virus

A two-year trial of entecavir followed by lamivudine (LAM) in patients with chronic hepatitis B virus (HBV) infection resulted in a virologic rebound rate of 24% and 12% drug-resistance rate. Patients who continued on entecavir therapy throughout the study period had undetectable HBV DNA at the two-year endpoint. Details of this trial are published in the April issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases..

31 Mar 2011

Immune therapy can control fertility in mammals

31 Mar 2011

Study: People who have survived diabetes for many decades exhibit few complications

Over time, diabetes can wreak havoc on the body's eyes, cardiovascular system, kidneys and nerves. A major study by Joslin Diabetes Center researchers, however, has found that some people who have survived diabetes for many decades exhibit remarkably few complications—a discovery that points toward the presence of protective factors that guard against the disease's effects.

31 Mar 2011

Genetic News and Research

Transgenomic to present study results of high-sensitivity cancer mutation assays at AACR

Series of new clinical trials confirm range of viable treatment options for HCV patients

Rsearchers define new step that controls programmed cell death in cancer cells

Loss of SKIP sensitizes cancer cells to apoptotic effects of DNA damage-inducing anticancer drugs

LCA calls for comprehensive plan of action to reduce lung cancer mortality

Study: MicroRNA can predict risk of BM in lung cancer patients

Biocept, academic collaborators' posters on CTCs to be presented at AACR meeting

NAMI launches new schizophrenia website and brochure

Early recognition and treatment can control obsessive-compulsive manifestation

Study shows immune therapy can prevent pregnancy in mammals including humans

New research finds HIV virus's V3 loop as attractive vaccine target

Study: Pseudokinases can play a crucial role in pathogen-based disease

Study confirms D-penicillamine and trientine effective against Wilson disease

Merck's VICTRELIS phase III study results against HCV presented at EASL annual meeting

DNA damage can lead to regulation of inflammatory responses

Conatus CTS-1027 Phase 2 trial results against HCV presented at EASL meeting

Mitochondrial defect inherited from mother is linked to high blood pressure in one Chinese family

Sequential treatment with Entecavir and Lamivudine results in rebound of hepatitis B virus

Immune therapy can control fertility in mammals

Study: People who have survived diabetes for many decades exhibit few complications

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