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Nanoparticles show potential as part of new therapy for advanced ovarian cancer

Nanoparticle delivery of diphtheria toxin-encoding DNA selectively expressed in ovarian cancer cells reduced the burden of ovarian tumors in mice, and researchers expect this therapy could be tested in humans within 18 to 24 months, according to a report in Cancer Research, a journal of the American Association for Cancer Research.

30 Jul 2009

Depression missed and misidentified

A meta-analysis of more than 50,000 patients has shown that general practitioners (GPs) have great difficulty separating those with and without depression, with substantial numbers of missed and misidentified.

30 Jul 2009

Protein level may predict severe osteoarthritis

Osteoarthritis (OA), the most common joint disorder throughout the world and a leading cause of disability, is characterized by pain, impaired joint mobility, reduction of muscular strength and loss of joint function. Unlike most other common diseases, little is known about its origins, and factors predicting a severe disease course have not been identified.

30 Jul 2009

Study finds few patients die from prostate cancer within 15 years of radical prostatectomy

Investigators at Memorial Sloan-Kettering Cancer Center (MSKCC), along with collaborating teams at the Cleveland Clinic and the University of Michigan, have completed the first large- scale, multi-institutional study of prostate cancer death after standard treatment to remove the prostate since PSA screening has become widely used as a method to screen for the disease.

28 Jul 2009

Deferoxamine could help diabetics heal wounds

A drug used to remove iron from the body could help doctors fight one of diabetes' cruelest complications: poor wound healing, which can lead to amputation of patients' toes, feet and even legs.

28 Jul 2009

Current diagnostic tests for ovarian cancer woefully ineffective

A new study finds that in order to make a significant dent in the mortality rate for the deadly cancer, the tests would have to be able to detect tumors of less than 1 cm in diameter, or about 200-times smaller in mass than those currently used to assess potential new tests. Still, if that hurdle can be overcome, there is good reason to believe that testing could make a big difference: The window of opportunity for treating these clinically undetectable cancers before they become life threatening is surprisingly long: about four years.

28 Jul 2009

Coronary calcium scoring may predict heart attack risk

Researchers may be able to predict future severe cardiac events in patients with known, stable coronary artery disease (CAD) using coronary calcium scoring, according to a study published in the online edition of Radiology.

28 Jul 2009

Artificial intelligence used to diagnose metastatic cancer

When doctors are managing care for women with breast cancer, the information available to them profoundly influences the type of care they recommend. Knowing whether a woman's cancer has metastasized, for instance, directly affects how her doctors will approach treatment -- which may in turn influence the outcome of that treatment.

28 Jul 2009

Smoking increases likelihood that pancreatic ductal adenocarcinoma will become metastatic

Smoking has once again been implicated in the development of advanced cancer. Exposure to nicotine by way of cigarette smoking may increase the likelihood that pancreatic ductal adenocarcinoma will become metastatic, according to researchers from the Kimmel Cancer Center at Jefferson.

27 Jul 2009

New system may allow use of xenon to protect newborn brain

Breathing xenon gas can help protect the infant brain from damage caused by oxygen deprivation, but the xenon's high cost and scarcity has precluded its widespread use.

27 Jul 2009

NHS on the cards for an ailing Australian health system

A new report is recommending a Federal takeover of the Australian public health and dental system - the report by the National Health and Hospitals Reform Commission (NHHRC) says the health system is under strain and in need of a new prescription.

27 Jul 2009

Surgery after chemotherapy and radiation can be an option for patients advanced lung cancer

In recent years, oncologists have debated whether patients with a certain type of advanced lung cancer would benefit from surgery.

26 Jul 2009

Major depressive disorder redefined

Researchers from Rhode Island Hospital's department of psychiatry propose that the definition for major depressive disorder (MDD) should be shortened to include only the mood and cognitive symptoms that have been part of the definition in the Diagnostic and Statistical Manual of Mental Disorders (DSM) for the past 35 years.

24 Jul 2009

Swine flu pandemic could overwhelm critical care beds in England, especially children’s units

Experts in intensive care and anaesthesia have predicted that the current swine flu pandemic could overwhelm critical care beds and ventilators in England, with hospitals on the South East Coast, and in the South West, East of England and East Midlands, being worst hit.

24 Jul 2009

Increased fighting makes humanitarian work, health situation more difficult in Somalia, U.N. says

Despite increasing danger posed by "al Qaeda-linked militants," U.N. Emergency Relief Coordinator John Holmes said Tuesday U.N. aid workers "were not backing away" from the country, Reuters reports.

22 Jul 2009

Potassium citrate wards off kidney stones in epilepsy patients on ketogenic diet

Children on the high-fat ketogenic diet to control epileptic seizures can prevent the excruciatingly painful kidney stones that the diet can sometimes cause if they take a daily supplement of potassium citrate the day they start the diet, according to research from Johns Hopkins Children's Center.

21 Jul 2009