Mouse Model News and Research

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Tipping the scales to initiate tumorigenesis in the colon

The regulatory protein c-MYC plays an important role in promoting the development of many types of tumors. c-MYC is a transcription factor that controls the activity of large numbers of genes involved in cell division, and its overexpression leads to excessive cell proliferation.

5 Sep 2018

Scientists receive $2.5 million grant to combat South American-borne deadly disease

A George Mason University researcher is heading a scientific team that has received a sizable Department of Defense grant to combat the threat of a South American-borne disease that can cause long-term neurological problems and even death.

5 Sep 2018

Mouse models may not completely reflect severity of gonorrhea infection

There is an urgent need to develop a vaccine to prevent gonorrhea infection due to rapidly increasing incidence and growing antibiotic resistance.

4 Sep 2018

Stanford researchers show how to prevent immune response to gene therapy in mouse model

Stanford University School of Medicine researchers have demonstrated that gene therapy can be effective without causing a dangerous side effect common to all gene therapy: an autoimmune reaction to the normal protein, which the patient's immune system is encountering for the first time.

4 Sep 2018

Neutrophil nanosponges provide hope for rheumatoid arthritis

Scientists in San Diego have developed nanosponges coated in neutrophil membranes that can prevent rheumatoid arthritis.

3 Sep 2018

Cryptosporidiosis worsened by commonly used probiotic

Researchers have found that infection with the intestinal parasite Cryptosporidium parvum is worsened in mice that have been administered a probiotic.

31 Aug 2018

Modified T lymphocytes prevent nerve cell damage in encephalitis

Scientists have found a way to prevent neuron death in Rasmussen’s encephalitis, by exploiting T lymphocytes in the immune system.

30 Aug 2018

HKBU chemists discover metal-based inhibitor to treat triple-negative breast cancer

Chemists at Hong Kong Baptist University have discovered the use of a metal compound that inhibits the enzyme closely associated with triple-negative breast cancer, one of the most difficult forms of breast cancer to treat.

30 Aug 2018

Soluble versions of immune cell protein could help treat Alzheimer's disease, study reveals

Researchers at the University of Florida have discovered that a modified version of an important immune cell protein could be used to treat Alzheimer's disease.

29 Aug 2018

Scientists discover potential treatment for Alzheimer’s disease

Scientists discovered a modified version of an immune cell receptor called a toll-like receptor that could be used as a treatment for Alzheimer’s disease.

29 Aug 2018

Lack of protein in father's diet can impact long-term health of his offspring

New research has shown that a lack of protein in a father's diet affects sperm quality which can have a direct impact on the long-term health of their offspring.

29 Aug 2018

New technique for mapping flow of biomolecules in tumor microenvironment

Cancer researchers struggle to identify tumor cells that are interspersed within nonmalignant tissues because tumor cells exploit the tissue environment and monopolize available resources to continue growing.

29 Aug 2018

Mice study reveals brain-heart biomarker for epilepsy after malaria

Animals that develop epilepsy after an infection can be identified as early as three months prior to their first seizure by measuring interactions between the brain and the heart.

From Society for Neuroscience 28 Aug 2018

Researchers reveal an unlikely protector against growth of metastatic breast cancer

At the time of initial diagnosis, most patients with breast cancer show no signs that their cancer has spread elsewhere in the body. Yet, up to 30 percent of patients will ultimately experience metastasis, with breast cancer taking root and growing at other sites in the body, sometimes months, years or even decades later.

27 Aug 2018

Proteins that protect neurons from destruction can be delivered through nose

Protective proteins that mitigate the destruction of nerve cells after a stroke can be administered into the brain through the nose, as Heidelberg University researchers demonstrated using a mouse model.

24 Aug 2018

New project receives $3.2 million grant to investigate secrets of programmed cell death in Alzheimer's

Most neurons in the human brain live out their lives, enduring the processes of aging before eventually dying. Some, however, choose a more violent route: suicide.

24 Aug 2018

Researchers work to create humanized mouse model to test immunotherapies

If a new anti-cancer drug shows promise in a Petri dish, often the next step is to test the drug's effect in mice. This system tends to work well with drugs that directly target cancer, but breaks down with immunotherapies.

24 Aug 2018

Researchers uncover how RNA regulates genes during critical stage in embryonic brain development

Scientists at the Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues discovered how a type of RNA, called Evf2 enhancer RNA, regulates key genes during a critical stage in embryonic brain development.

24 Aug 2018

Research identifies cell signaling pathways related to endocannabinoid system in worms

Like mammals, parasitic worms have an endocannabinoid system that may help the worm and the hosts it infects survive by reducing pain and inflammation in the host, according to a "wild" new discovery by an interdisciplinary research team at the University of California, Riverside.

23 Aug 2018

Scientists discover how a protein in the brain maintains 'energy rheostasis'

Scientists at the University of Michigan and Vanderbilt University have identified the function of a protein that has been confounding metabolism researchers for more than two decades. And it may have implications both for treating obesity and for understanding weight gain during pregnancy and menopause.

23 Aug 2018

Mouse Model News and Research

Tipping the scales to initiate tumorigenesis in the colon

Scientists receive $2.5 million grant to combat South American-borne deadly disease

Mouse models may not completely reflect severity of gonorrhea infection

Stanford researchers show how to prevent immune response to gene therapy in mouse model

Neutrophil nanosponges provide hope for rheumatoid arthritis

Cryptosporidiosis worsened by commonly used probiotic

Modified T lymphocytes prevent nerve cell damage in encephalitis

HKBU chemists discover metal-based inhibitor to treat triple-negative breast cancer

Soluble versions of immune cell protein could help treat Alzheimer's disease, study reveals

Scientists discover potential treatment for Alzheimer’s disease

Lack of protein in father's diet can impact long-term health of his offspring

New technique for mapping flow of biomolecules in tumor microenvironment

Mice study reveals brain-heart biomarker for epilepsy after malaria

Researchers reveal an unlikely protector against growth of metastatic breast cancer

Proteins that protect neurons from destruction can be delivered through nose

New project receives $3.2 million grant to investigate secrets of programmed cell death in Alzheimer's

Researchers work to create humanized mouse model to test immunotherapies

Researchers uncover how RNA regulates genes during critical stage in embryonic brain development

Research identifies cell signaling pathways related to endocannabinoid system in worms

Scientists discover how a protein in the brain maintains 'energy rheostasis'

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