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Abnormally active Rab5 protein leads to early development of neurodegenerative disease

Writing in the April 11 issue of The Journal of Clinical Investigation, researchers at University of California, San Diego School of Medicine say abnormalities in a protein that helps transport and sort materials inside cells are linked to axonal dysfunction and degeneration of neurons in Alzheimer's disease (AD) and Down syndrome (DS).

12 Apr 2016

Low-level exposures to air pollution may affect normal lung function in children

Dramatic improvements in air quality in U.S. cities since the 1990s may not be enough to ensure normal lung function in children, according to new research published in the April 15 American Journal of Respiratory and Critical Care, a journal of the American Thoracic Society.

12 Apr 2016

BMPR2 mutations affect outcomes of PAH patients

Mutations in the bone morphogenetic protein receptor type II gene affect not only the risk of developing pulmonary arterial hypertension but also the severity and outcomes of the disease, shows a meta-analysis of individual patient data.

12 Apr 2016

Increased expression of VEGF-A promotes three common aging-related eye conditions

A Massachusetts General Hospital investigator has found that increased expression of the angiogenic factor VEGF-A promotes three common aging-related eye conditions - both versions of age-related macular degeneration (AMD) and also cataracts - in an animal model.

12 Apr 2016

Mouse-based study shows exercise decreases cancer incidence, slows tumor growth

When you're pounding along an icy pavement or sweating through a gym workout, you try to remind yourself of the many health benefits of exercise. Between gasps, you can say that a healthy, fit lifestyle helps prevents obesity, a worldwide problem of increasing magnitude that has been linked to cardiovascular disease and diabetes.

11 Apr 2016

Researchers link alcohol, cocaine misuse with future suicide attempt

In a general sense, medical studies support the popular intuition -- a staple of movies and literature -- that suicidal behavior and substance misuse are linked. But the relationship between the two is not so simple. A new study of hundreds of suicidal emergency department (ED) patients from around the U.S. found that the significance of the link varied with age, gender and race. Across the board, however, the use of cocaine and alcohol together was a red flag.

11 Apr 2016

Noviplex card could accelerate testing for Zika virus in the Amazonian region of Brazil

A University of Nebraska-Lincoln researcher is partnering with Brazilian officials to distribute a device that could accelerate testing for the Zika virus and monitor contamination of the country's freshwater food sources.

11 Apr 2016

Researchers find evidence that protein involved in regulating inflammation has anti-septic effects

Sepsis represents a serious complication of infection and is one of the leading causes of death and critical illness worldwide due in part to the lack of effective therapies. A report in the American Journal of Pathology provides evidence from both mouse and human studies that SHARPIN, a protein involved in regulating inflammation, has anti-septic effects. These findings may spur development of novel sepsis treatments.

11 Apr 2016

Zika virus may be linked to autoimmune disorder that attacks the brain's myelin

The Zika virus may be associated with an autoimmune disorder that attacks the brain's myelin similar to multiple sclerosis, according to a small study that is being released today and will be presented at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016.

11 Apr 2016

Cigarette smoking, viral infections may reduce effectiveness of COPD symptom-reliever medication

New study backs up observations in Chronic Obstructive Pulmonary Disease (COPD) patients showing reduced effectiveness of symptom-reliever medication (β2-adrenoceptor agonists) in flare-ups linked to cigarette smoking and infection with viruses such as influenza.

11 Apr 2016

Study reveals new activation mechanism for protein kinases

Protein kinases, most scientists would agree, regulate nearly every aspect of cell life. It is no surprise, then, that having faulty protein kinases may lead to a number of human conditions, including cardiovascular diseases, cancer and diabetes.

11 Apr 2016

Keynotes announced for ECCMID 2016

The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) previews some of the keynote lectures at the 26th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). The globe’s most prominent infection specialists will be gathering at its annual congress in Amsterdam from 9 – 12 April 2016.

8 Apr 2016

Rituximab shows second-line promise in autoimmune limbic encephalitis

Rituximab is an effective and well-tolerated second-line treatment for patients with autoimmune limbic encephalitis, suggests research.

7 Apr 2016

Epilepsy drug exposure does not increase newborn orofacial cleft risk

Pregnant women with epilepsy should not rule out continuing lamotrigine therapy due to concerns that exposure could increase the risk of orofacial clefts in their babies, say investigators.

7 Apr 2016

Vanderbilt's A.S.A.P sees increase in number of patients treated for alpha-gal syndrome

Vanderbilt's Asthma, Sinus and Allergy Program (A.S.A.P) has seen an increase in the number of patients being treated for alpha-gal syndrome, commonly known as the red meat allergy linked to tick bites.

7 Apr 2016

Diabetes cases have quadrupled from 108 million to 422 million since 1980

Since 1980, the number of adults with diabetes worldwide has quadrupled from 108 million to 422 million in 2014, according to a new study published in The Lancet. The findings provide the most comprehensive estimates of worldwide diabetes trends to date and show that diabetes is fast becoming a major problem in low and middle income countries.

7 Apr 2016

Baker’s yeast could help in finding disease-causing mutations

It's easier than ever to sequence our DNA, but doctors still can't exactly tell from our genomes which diseases might befall us. Professor Fritz Roth is setting out to change this by going to basics -- to our billion-year-old cousin, baker's yeast.

7 Apr 2016

Novel metabolic pathways help cancer cells thrive under certain conditions

Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have identified a novel metabolic pathway that helps cancer cells thrive in conditions that are lethal to normal cells.

7 Apr 2016

LivaNova announces first implant of Perceval sutureless valve in PERSIST-AVR trial

LivaNova, PLC, a global medical technology company, announced today the first implant of the Perceval sutureless valve in the PERSIST-AVR trial at CHU Brabois, University of Lorraine, Nancy, France.

7 Apr 2016

Better management of blood sugar, blood pressure and LDL-cholesterol levels could reduce cardiovascular risk

While controlling blood pressure, blood sugar and LDL-cholesterol levels reduces the risk of cardiovascular disease in people with diabetes, only 7 percent of diabetic participants in three major heart studies had recommended levels of these three factors, according to research from the Heart Disease Prevention Program at the University of California, Irvine School of Medicine.

6 Apr 2016

X linked News and Research

Abnormally active Rab5 protein leads to early development of neurodegenerative disease

Low-level exposures to air pollution may affect normal lung function in children

BMPR2 mutations affect outcomes of PAH patients

Increased expression of VEGF-A promotes three common aging-related eye conditions

Mouse-based study shows exercise decreases cancer incidence, slows tumor growth

Researchers link alcohol, cocaine misuse with future suicide attempt

Noviplex card could accelerate testing for Zika virus in the Amazonian region of Brazil

Researchers find evidence that protein involved in regulating inflammation has anti-septic effects

Zika virus may be linked to autoimmune disorder that attacks the brain's myelin

Cigarette smoking, viral infections may reduce effectiveness of COPD symptom-reliever medication

Study reveals new activation mechanism for protein kinases

Keynotes announced for ECCMID 2016

Rituximab shows second-line promise in autoimmune limbic encephalitis

Epilepsy drug exposure does not increase newborn orofacial cleft risk

Vanderbilt's A.S.A.P sees increase in number of patients treated for alpha-gal syndrome

Diabetes cases have quadrupled from 108 million to 422 million since 1980

Baker’s yeast could help in finding disease-causing mutations

Novel metabolic pathways help cancer cells thrive under certain conditions

LivaNova announces first implant of Perceval sutureless valve in PERSIST-AVR trial

Better management of blood sugar, blood pressure and LDL-cholesterol levels could reduce cardiovascular risk

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