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Inhibition of SIRT1 protein may hold promise for treatment of metastatic Ewing sarcoma

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL), led by Oscar Martínez Tirado participated in an international study which suggests inhibition of Sirtuin1 (SIRT1) protein as a future treatment option for metastatic Ewing sarcoma. The results of the study were published in the journal Cancer Research.

31 Jan 2015

Project Spark to advance neuroprotective drug for schizophrenia-associated cognitive impairment

A public-private consortium led by the biotech Iproteos -based at Parc Científic de Barcelona (PCB)-, and comprised by the biopharmaceutical company Ascil-Biopharma, the Institute for Biomedical Research (IRB Barcelona), the Centre for Genomic Regulation (CRG) and the University of the Basque Country (UPV/EHU) has launched a project to advance the development of a new neuroprotective drug for the treatment of the cognitive impairment associated with schizophrenia and other mental disorders.

31 Jan 2015

Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

The Damon Runyon Cancer Research Foundation, a non-profit organization focused on supporting innovative early career researchers, named 15 new Damon Runyon Fellows at its fall Fellowship Award Committee review. The recipients of this prestigious, four-year award are outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators across the country.

31 Jan 2015

Nanoscale DNA tool to detect molecular behavior

A complex interplay of molecular components governs almost all aspects of biological sciences - healthy organism development, disease progression, and drug efficacy are all dependent on the way life's molecules interact in the body. Understanding these bio-molecular interactions is critical for the discovery of new, more effective therapeutics and diagnostics to treat cancer and other diseases, but currently requires scientists to have access to expensive and elaborate laboratory equipment.

31 Jan 2015

Blood tests for Chikungunya virus and rheumatoid arthritis could produce similar results

A mosquito-borne virus that has spread to the Caribbean and Central and South America and has caused isolated infections in Florida often causes joint pain and swelling similar to that seen in patients with rheumatoid arthritis.

31 Jan 2015

NCCN commemorates 20 years of advancing high-quality, high-value cancer care

On January 31, 2015, the National Comprehensive Cancer Network celebrates its 20th anniversary. Originally announced as an alliance of 13 leading cancer centers in 1995, NCCN has grown to a network of 25 academic cancer centers; the NCCN mission as an alliance of leading academic cancer centers devoted to patient care, research, and education, is to improve the quality, effectiveness, and efficiency of cancer care so that patients can live better lives.

31 Jan 2015

Multiplexed testing for EGFR and ALK gene rearrangements may be cost-effective for NSCLC treatment

Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker-guided treatment is cost-effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States.

31 Jan 2015

Micromotor fueled by stomach acid effectively delivers gold nanoparticles

Researchers at the University of California, San Diego have shown that a micromotor fueled by stomach acid can take a bubble-powered ride inside a mouse. These tiny motors, each about one-fifth the width of a human hair, may someday offer a safer and more efficient way to deliver drugs or diagnose tumors.

31 Jan 2015

Cell-penetrating nanoparticles can efficiently transport oligonucleotide drugs into cells

Therapeutic oligonucleotide analogs represent a new and promising family of drugs that act on nucleic acid targets such as RNA or DNA; however, their effectiveness has been limited due to difficulty crossing the cell membrane.

31 Jan 2015

Pancreatic cancer cells know a way to sidestep chemotherapy, reveal Fox Chase researchers

Pancreatic cancer is one of the deadliest forms of the disease. The American Cancer Society's most recent estimates for 2014 show that over 46,000 people will be diagnosed with pancreatic cancer and more than 39,000 will die from it. Now, research led by Timothy J. Yen, PhD, Professor at Fox Chase Cancer Center, reveals that one reason this deadly form of cancer can be so challenging to treat is because its cells have found a way to sidestep chemotherapy.

30 Jan 2015

Scientists identify strong link between beclin 1 gene and triple-negative breast cancer

UT Southwestern Medical Center scientists have identified a strong link between the most aggressive type of breast cancer and a gene that regulates the body's natural cellular recycling process, called autophagy.

30 Jan 2015

Shire announces FDA approval of Vyvanse Capsules for binge eating disorder

Shire plc announced today that the U.S. Food and Drug Administration approved Vyvanse (lisdexamfetamine dimesylate) Capsules (CII), the first and only medication for the treatment of moderate to severe binge eating disorder (B.E.D.) in adults, shown to significantly reduce the mean number of binge days per week.

30 Jan 2015

Researchers identify molecular pathways that could lead to new therapeutic targets for cerebral malaria

A drug already approved for treating other diseases may be useful as a treatment for cerebral malaria, according to researchers at Harvard T. H. Chan School of Public Health. They discovered a novel link between food intake during the early stages of infection and the outcome of the disease, identifying two molecular pathways that could serve as new targets for treatment.

30 Jan 2015

Research shows effectiveness of Tamiflu

Earlier this month, the Centers for Disease Control and Prevention recommended the use of antiviral drugs to help treat influenza, in a year when the available vaccine is not a good match for the current strain.

30 Jan 2015

Synthetic compound shows antibiotic action against MRSA

Microbiologists and chemists at the University of South Florida have developed and patented a synthetic compound that has shown antibiotic action against methicillin resistant Staphylococcus aureus, also known as MRSA, which can cause many serious infections and deaths.

30 Jan 2015

AstraZeneca announces research collaborations to use genome-editing tool for drug discovery and development

AstraZeneca today announced four research collaborations aimed at harnessing the power of CRISPR, a pioneering genome-editing technique, across its entire discovery platform in the company’s key therapeutic areas.

30 Jan 2015

Research reveals key protein structure, paves way for better anti-anxiety drugs

When new medicines are invented, the drug may hit the intended target and nullify the symptoms, but nailing a bull's eye - one that produces zero side effects - can be quite elusive.

30 Jan 2015

Immunotherapy expert discusses the concept of precision immunology and personalized medicine

With President Obama's recent State of the Union speech addressing the launch of a national precision medicine initiative to further tackle cancer and other diseases, a leading immunotherapy expert from Rutgers Cancer Institute of New Jersey weighs in on where we stand with precision immunology and personalized medicine and what needs to be accomplished.

30 Jan 2015

Study helps develop better understanding of how dopamine influences behaviour

Scientists studying hatchling fish have made a new advance in studying a chemical in the brain that impacts on movement.

29 Jan 2015

Researchers create customized soap bubbles that promote drug and vaccine delivery

When University of Maryland Professors Philip DeShong and Daniel Stein began tagging soap bubbles with biomolecules, they had no idea this technology would one day be poised to change the way drugs and vaccines fight against bacteria, viruses and cancer.

29 Jan 2015

Drugs News and Research

Inhibition of SIRT1 protein may hold promise for treatment of metastatic Ewing sarcoma

Project Spark to advance neuroprotective drug for schizophrenia-associated cognitive impairment

Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

Nanoscale DNA tool to detect molecular behavior

Blood tests for Chikungunya virus and rheumatoid arthritis could produce similar results

NCCN commemorates 20 years of advancing high-quality, high-value cancer care

Multiplexed testing for EGFR and ALK gene rearrangements may be cost-effective for NSCLC treatment

Micromotor fueled by stomach acid effectively delivers gold nanoparticles

Cell-penetrating nanoparticles can efficiently transport oligonucleotide drugs into cells

Pancreatic cancer cells know a way to sidestep chemotherapy, reveal Fox Chase researchers

Scientists identify strong link between beclin 1 gene and triple-negative breast cancer

Shire announces FDA approval of Vyvanse Capsules for binge eating disorder

Researchers identify molecular pathways that could lead to new therapeutic targets for cerebral malaria

Research shows effectiveness of Tamiflu

Synthetic compound shows antibiotic action against MRSA

AstraZeneca announces research collaborations to use genome-editing tool for drug discovery and development

Research reveals key protein structure, paves way for better anti-anxiety drugs

Immunotherapy expert discusses the concept of precision immunology and personalized medicine

Study helps develop better understanding of how dopamine influences behaviour

Researchers create customized soap bubbles that promote drug and vaccine delivery

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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