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Statins reduce the formation of brown adipose tissue

A certain proportion of the adult population has not only white adipose (or fatty) tissue, but also the brown kind. This brown adipose tissue helps to convert sugar and fat into heat. People with brown adipose tissue are better at regulating their body temperature in the winter, and are less likely to suffer from excess weight or diabetes.

21 Dec 2018

FDA approves new treatment for rare disease of the bone marrow and blood

The U.S. Food and Drug Administration today approved Elzonris (tagraxofusp-erzs) infusion for the treatment of blastic plasmacytoid dendritic cell neoplasm in adults and in pediatric patients, two years of age and older.

21 Dec 2018

Cell-free DNA can be used to predict biological age, according to a new study

Scientists have found that cell-free DNA (cfDNA) within in the blood can reflect differences in the age and health of individuals.

21 Dec 2018

Simple protocol rescues stressed liver cells

Isolated human hepatocytes are essential tools in preclinical and clinical liver research, but cell quality is highly variable. Now, researchers from Uppsala University have devised a simple protocol that improves hepatocyte quality and enables cells from a wider quality spectrum to be used in standard and advanced cell culture. The findings are published in Archives of Toxicology.

21 Dec 2018

Scientists uncover direct link between brain cell size and IQ level

Scientists working within the Human Brain Project have for the first time uncovered a direct relation between brain cell size and IQ level.

21 Dec 2018

New data demonstrates clinical utility of AlloSure in repeat kidney transplant recipients

CareDx, Inc., a leading molecular diagnostics company focused on the discovery, development and commercialization of clinically differentiated, high-value diagnostic solutions for transplant patients, today announces the publication of data demonstrating the clinical utility of measuring AlloSure in repeat kidney transplant recipients in the American Journal of Transplantation.

21 Dec 2018

Researchers reveal novel mechanism for sperm stem cell number control

The steady production of sperm relies on the number of sperm stem cells in the testis remaining constant. Researchers including Asst. Prof. Yu Kitadate and Prof. Shosei Yoshida and Prof. Benjamin Simons have revealed a novel mechanism for stem cell number control.

21 Dec 2018

Researchers reveal how dietary intervention can help prevent autoimmune disease in mice

Could a change in diet be beneficial to people with autoimmune diseases such as lupus? A Yale-led team of researchers have revealed how a dietary intervention can help prevent the development of this autoimmune disease in susceptible mice.

21 Dec 2018

Change in genome of Caucasians could explain higher rates of esophageal cancer

A change in the genome of Caucasians could explain much-higher rates of the most common type of esophageal cancer in this population, a new study finds.

21 Dec 2018

New approach to destroy HIV reservoirs

Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus - it is their metabolic (or energy-producing) activity1 that enables the virus to multiply.

21 Dec 2018

Researchers discover new changes occurring in the brain in early Alzheimer's disease

Researchers at the University of Eastern Finland have discovered new changes occurring in the human brain in the early stages of Alzheimer's disease.

21 Dec 2018

Study: Cholesterol uptake is decreased in GM3S-deficient cells

Approximately 1 in every 4 deaths in the United States is caused by heart disease, according to the Centers for Disease Control and Prevention.

21 Dec 2018

Lupus Research Alliance announces 2018 recipients of the Distinguished Innovator Award

The Lupus Research Alliance is proud to announce the 2018 recipients of the Dr. William E. Paul Distinguished Innovator Award in Lupus and Autoimmunity: Nir Hacohen, PhD and Vijay Kuchroo, DVM, PhD. Dr. Hacohen is seeking better ways to treat lupus kidney disease, the major cause of illness and death among patients with lupus.

21 Dec 2018

Researchers present mechanisms, cellular targets involved with effects of TGF-Beta 1 muscle

The innate immune system comprises of various soluble factors that provide the first line of defense against pathogens.

21 Dec 2018

Elegant, low-cost approach enhances single-cell RNA sequencing

Droplet microfluidics has revolutionized single-cell RNA sequencing, offering a low-cost, high-throughput method for single-cell genomics. However, this method has been limited in its ability to capture complete RNA transcription information.

20 Dec 2018

FDA warns Genetech for marketing stem cell products without approval

The U.S. Food and Drug Administration has warned Genetech, Inc. of San Diego, California and its president, Edwin N. Pinos for marketing stem cell products without FDA approval and for significant deviations from current good tissue practice and current good manufacturing practice requirements, including some violations that may have led to microbial contamination, potentially causing serious blood infections in patients.

20 Dec 2018

New portable optical imaging system brings diagnostic potential into operating room

A team of University of Illinois at Urbana-Champaign researchers led by Professor Stephen Boppart has successfully visualized the tumor microenvironment of human breast tissue shortly after it was surgically removed from a patient in the operating room.

20 Dec 2018

New study reveals how fatty diet can lead to serious form of liver disease

A new study by Keck School of Medicine of USC researchers shows there's yet another reason to avoid a high fat, high cholesterol diet: It can trigger changes in the immune system that lead to a serious form of non-alcoholic fatty liver disease known as non-alcoholic steatohepatitis.

20 Dec 2018

Study lays foundation for addressing unresolved questions in human aging

Doctors have long observed that biological age and chronological age are not always one and the same. A 55-year-old may exhibit many signs of old age and have numerous age-related diseases, whereas an 80-year-old may be healthy and robust.

20 Dec 2018

Experimental gene therapy extends lifespan of mice suffering from untreatable mitochondrial disease

Researchers at the University of Helsinki and Folkhälsan Research Center have, together with their collaborators, for the first time demonstrated in a mouse model that partial restoration of respiratory chain function in mitochondria, which serve as cellular power plants, may be sufficient to entirely prevent symptoms of a severe mitochondrial disorder.

20 Dec 2018