Genes News and Research

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Controlling for size may also prevent cancer

Scientists at Johns Hopkins recently discovered that a chemical chain reaction that controls organ size in animals ranging from insects to humans could mean the difference between normal growth and cancer.

21 Sep 2007

Ancient mechanism for coping with stresses also gives cancer a boost

An ancient mechanism for coping with environmental stresses, including heat and toxic exposures, also helps cancerous tumors survive, reveals a new report in the Sept. 21, 2007, issue of Cell, a publication of Cell Press.

21 Sep 2007

Heat shock proteins are co-opted for cancer

A Jekyll-Hyde mechanism that both protects healthy cells and enables cancer cells could be the basis for new cancer-fighting drugs.

20 Sep 2007

DNA microarray chips improved therapy in some patients with incurable cancer

Like many oncologists, Eric P. Lester, M.D., was faced with a dilemma: seven patients with advanced, incurable cancer, an arsenal of drugs that may or may not help them, and not enough solid proof about treatment efficacy to guide him.

20 Sep 2007

Drug resistance gene has spread from East Coast to Midwest

A resistance gene that allows bacteria to beat an important class of antibiotics has started to appear in microorganisms taken from Midwestern patients, according to researchers at Washington University School of Medicine in St. Louis.

20 Sep 2007

3-D Petri dish that grows cells in three dimensions

A team of Brown University biomedical engineers has invented a 3-D Petri dish that can grow cells in three dimensions, a method that promises to quickly and cheaply produce more realistic cells for drug development and tissue transplantation.

20 Sep 2007

Test for lung cancer looks for discomforting quiet among protective genes

When it is quiet – "almost too quiet" – in movies, it is a sign that something is about to go wrong for the good guys.

18 Sep 2007

Re-engineered human T cells effectively target and kill cancerous B cells

Human white blood cells, engineered to recognize other malignant immune cells, could provide a novel therapy for patients with highly lethal B cell cancers such as acute lymphoblastic leukemia (ALL), according to researchers at Memorial Sloan-Kettering Cancer Center (MSKCC).

18 Sep 2007

New cell death pathway involved in sperm development

Heavy and bulky sperm would not be good swimmers. To trim down, sperm rely on cell death proteins called caspases, which facilitate the removal of unwanted cellular material and radically remodel these cells into their sleek, light shape.

18 Sep 2007

Rheumatoid arthritis genes

A paper published this week in the open access journal PLoS Medicine provides strong evidence that one specific part of the genome is associated with rheumatoid arthritis.

18 Sep 2007

Gene profiling can single out the worst cases of multiple myeloma and guide therapy

Multiple myeloma patients vary widely in how they respond to treatment, but now researchers at the Myeloma Institute for Research and Therapy at the University of Arkansas for Medical Sciences have identified a small subset of genes whose activity could predict high-risk cases and potentially guide therapy in the future.

18 Sep 2007

New DNA technique will speed up chemical compensation claims

A new DNA technique developed by scientists in the U.S. may help prove if people have had their health damaged by exposure to chemicals.

18 Sep 2007

Scientists learn three-dimensional structure of enzyme in unusual virus

Biologists have determined the three-dimensional structure of an unusual viral enzyme that is required in the assembly of new viruses.

18 Sep 2007

Smoking-cessation may be in the genes

Whether a smoking-cessation drug will enable you to quit smoking may depend on your genes, according to new genotyping research from the Centre for Addiction and Mental Health (CAMH).

18 Sep 2007

Mechanism for the in-vivo transport of siRNA

It all started with flowers: in the nineties of the last century Norwegian researchers discovered that additional copies of a particular gene in petunias inhibited its activity instead of reinforcing it as had been assumed.

18 Sep 2007

JAK genes and cancer

Cancer-causing genes can work in more powerful and sneaky ways than have been realized.

18 Sep 2007

Mutations in the glucocerebrosidase gene are risk factors for Parkinson's disease

People with a certain gene mutation are more likely to get Parkinson's disease before the age of 50 compared to those without the gene abnormality, according to a study published in the September 18, 2007, issue of Neurology, the medical journal of the American Academy of Neurology.

18 Sep 2007

Genetic lab test for Warfarin sensitivity approved by FDA

The U.S. Food and Drug Administration today cleared for marketing a new genetic test that will help physicians assess whether a patient may be especially sensitive to the blood-thinning drug warfarin (Coumadin), which is used to prevent potentially fatal clots in blood vessels.

18 Sep 2007

The importance of gene regulation for common human disease

A new study published in Nature Genetics on Sunday 16 September 2007 show that common, complex diseases are more likely to be due to genetic variation in regions that control activity of genes, rather than in the regions that specify the protein code.

17 Sep 2007

Scientists synthesize DNA-based memory loop in yeast cells

Harvard Medical School researchers have successfully synthesized a DNA-based memory loop in yeast cells, findings that mark a significant step forward in the emerging field of synthetic biology.

17 Sep 2007