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UTHealth scientists use new methods to explore naturally occurring 'knockout humans'

Researchers at The University of Texas Health Science Center at Houston are helping to make precision medicine a reality by sequencing entire exomes of people to assess chronic disease risk and drug efficacy. The results of a study on this topic were published in Nature Genetics on Monday.

30 Apr 2015

Promising compound blocks production of beta amyloid peptides in Alzheimer's mouse model

Offering a potential early intervention for Alzheimer's disease (AD), researchers at University of California, San Diego School of Medicine and Cenna Biosciences, Inc. have identified compounds that block the production of beta amyloid peptides in mice.

30 Apr 2015

Research provides insights into the ability of FL118 to overcome treatment resistance

The latest research from the team that discovered the novel anticancer agent FL118 highlights distinctive characteristics of this small-molecule compound and provides insights into its ability to overcome the persistent problem of treatment resistance. In findings reported in Molecular Cancer, Fengzhi Li, PhD, of Roswell Park Cancer Institute, and colleagues provide new evidence that FL118 may be more effective than two structurally similar injectable drugs and, additionally, may be effective as an oral agent.

30 Apr 2015

Study opens door for new therapeutic approaches to treating patients with melanoma

Weill Cornell Medical College researchers have shown for the first time that a gene previously implicated in blood vessel formation during embryonic development and tumor growth also induces immune suppression during tumor development.

30 Apr 2015

Type 2 diabetics can eat more protein at breakfast to reduce glucose spikes at breakfast and lunch

Individuals with Type 2 Diabetes have difficulty regulating their glucose -- or blood sugar -- levels, particularly after meals. Now, University of Missouri researchers have found that Type 2 diabetics can eat more protein at breakfast to help reduce glucose spikes at both breakfast and lunch.

30 Apr 2015

Link between dDsk2 protein and neurodegenerative diseases identified

Until today, the proteins known as ubiquitin receptors have been associated mainly with protein degradation, a basic cell cleaning process. A new function now described for the protein dDsk2 by the team headed by Ferran Azorín, group leader at the Institute for Research in Biomedicine (IRB Barcelona) and CSIC research professor, links ubiquitin receptors for the first time with the regulation of gene expression.

29 Apr 2015

Researchers discover key mechanism in neural death that causes Parkinson's disease

In studying the molecular biology of brain development, a team of researchers led by Ludwig Stockholm director Thomas Perlmann has discovered how disruption of a developmental mechanism alters the very nerve cells that are most affected in Parkinson's disease.

29 Apr 2015

Scientists reveal complex role of soy in preventing and advancing breast cancer

Scientists have mapped the human genes triggered by the phytonutrients in soy, revealing the complex role the legume plays in both preventing and advancing breast cancer.

29 Apr 2015

International study finds that two-week diet swap for African-Americans may lower colon cancer risk

African-Americans and Africans who swapped their typical diets for just two weeks similarly exchanged their respective risks of colon cancer as reflected by alterations of their gut bacteria, according to an international study led by researchers at the University of Pittsburgh School of Medicine published online today in Nature Communications.

29 Apr 2015

Two world-renowned scientists receive Poland-U.S. Science Award

World-renowned scientists -- Prof. Mariusz Jaskólski of Adam Mickiewicz University in Poznań, Poland, and Dr. Alexander Wlodawer of the National Cancer Institute, USA -- are the first winners of the Poland-U.S. Science Award granted jointly by the Foundation for Polish Science and the American Association for the Advancement of Science, the world's largest scientific association.

29 Apr 2015

Dramatic effects on colon cancer risk for Americans and Africans when diet swapped

Scientists have found dramatic effects on risk factors for colon cancer when American and African volunteers swapped diets for just two weeks.

28 Apr 2015

PAML signs collaborative agreement with Axela

PAML announced today that the laboratory has entered into a collaborative agreement with Axela, Inc. to develop multiplex assays focused on immune status for vaccine preventable diseases. PAML is one of the nation's leading medical reference laboratories, and Axela focuses on multiplexed nucleic acid and protein analysis for clinical diagnostics.

28 Apr 2015

PCDx test performs better than FoundationOne test in clinical study

Data from a small cohort published OncoTargets and Therapy today shows that the Paradigm Cancer Diagnostic Test (PCDx) performed better than Foundation Medicine's FoundationOne test across a number of key clinical variables, including turnaround time (TAT) and clinically actionable biomarker targets.

28 Apr 2015

Researchers identify molecular switch for protein that causes HER2-positive breast cancer

Herceptin has been touted as a wonder drug for women with HER2-positive breast cancer, an aggressive form of the disease that is fueled by excess production of the HER2 protein. However, not all of these patients respond to the drug, and many who do respond eventually acquire resistance.

28 Apr 2015

TSRI study provides new insight into preventing diseases that cause vision loss in adults

A new study from scientists at The Scripps Research Institute shows that nerve cells and blood vessels in the eye constantly "talk" to each other to maintain healthy blood flow and prevent disease.

28 Apr 2015

Researchers pinpoint new mechanism responsible for malaria progression

A team of researchers from four universities has pinpointed one of the mechanisms responsible for the progression of malaria, providing a new target for possible treatments.

28 Apr 2015

Discovery of molecular reset button for internal body clock could help treat different disorders

An international team of scientists has discovered what amounts to a molecular reset button for our internal body clock. Their findings reveal a potential target to treat a range of disorders, from sleep disturbances to other behavioral, cognitive, and metabolic abnormalities, commonly associated with jet lag, shift work and exposure to light at night, as well as with neuropsychiatric conditions such as depression and autism.

28 Apr 2015

Gladstone researchers identify way to prevent MS development in mice

Scientists from the Gladstone Institutes have discovered a way to prevent the development of multiple sclerosis (MS) in mice. Using a drug that blocks the production of a certain type of immune cell linked to inflammation and autoimmunity, the researchers successfully protected against the onset of MS in an animal model of the disease.

28 Apr 2015

Study suggests that inhibiting FOXO1 protein could speed diabetic wound healing

A protein that normally fosters tissue repair instead acts to inhibit healing when sugar levels are high, according to a study in The Journal of Cell Biology. The role reversal helps explain why wounds heal slowly in people with diabetes.

28 Apr 2015

TAXIS Pharmaceuticals' TXA709 compound shows promise in combating antibiotic resistance

TAXIS Pharmaceuticals, a drug-discovery company focused on developing a new class of antibiotic agents to treat life-threatening, multidrug-resistant bacterial infections, today announced the presentation of data demonstrating the promise of its lead clinical candidate, TXA709, in combating antibiotic resistance.

27 Apr 2015

Protein C News and Research

UTHealth scientists use new methods to explore naturally occurring 'knockout humans'

Promising compound blocks production of beta amyloid peptides in Alzheimer's mouse model

Research provides insights into the ability of FL118 to overcome treatment resistance

Study opens door for new therapeutic approaches to treating patients with melanoma

Type 2 diabetics can eat more protein at breakfast to reduce glucose spikes at breakfast and lunch

Link between dDsk2 protein and neurodegenerative diseases identified

Researchers discover key mechanism in neural death that causes Parkinson's disease

Scientists reveal complex role of soy in preventing and advancing breast cancer

International study finds that two-week diet swap for African-Americans may lower colon cancer risk

Two world-renowned scientists receive Poland-U.S. Science Award

Dramatic effects on colon cancer risk for Americans and Africans when diet swapped

PAML signs collaborative agreement with Axela

PCDx test performs better than FoundationOne test in clinical study

Researchers identify molecular switch for protein that causes HER2-positive breast cancer

TSRI study provides new insight into preventing diseases that cause vision loss in adults

Researchers pinpoint new mechanism responsible for malaria progression

Discovery of molecular reset button for internal body clock could help treat different disorders

Gladstone researchers identify way to prevent MS development in mice

Study suggests that inhibiting FOXO1 protein could speed diabetic wound healing

TAXIS Pharmaceuticals' TXA709 compound shows promise in combating antibiotic resistance

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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