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Health Canada to review evidence on the safety of long-term use of prescription blood-thinners

Health Canada is aware of and will be reviewing new evidence on the safety of long-term use of the prescription blood-thinners clopidogrel (Plavix) and prasugrel (Effient).

18 Nov 2014

Zytiga is commonly prescribed for second-line treatment of mCRPC patients

Decision Resources Group finds that Johnson & Johnson/Janssen Biotech/Janssen Cilag/AstraZeneca's Zytiga is the clear agent of choice for second-line treatment of metastatic castrate-resistant prostate cancer (mCRPC) patients, according to surveyed oncologists from France, Germany, Italy, Spain, and the United Kingdom (EU5).

18 Nov 2014

Study identifies new gene for progressive form of epilepsy

A study led by researchers at University of Helsinki, Finland and Universities of Melbourne and South Australia has identified a new gene for a progressive form of epilepsy. The findings of this international collaborative effort have been published today, 17 November 2014, in Nature Genetics.

18 Nov 2014

New research suggests potential role for MEK inhibitors in type 2 diabetes

A research team led by Brigham and Women's Hospital and Dana-Farber Cancer Institute has uncovered surprising new findings that underscore the role of an important signaling pathway, already known to be critical in cancer, in the development of type 2 diabetes.

18 Nov 2014

FDA grants Orphan Drug Designation to Juno's JCAR015 leukemia T cell product candidate

Juno Therapeutics, Inc. announced today that the FDA has granted Orphan Drug Designation to its JCAR015 chimeric antigen receptor product candidate. The designation was granted for treatment of acute lymphoblastic leukemia. JCAR015 Phase I trials are currently underway at Juno's collaboration partner, Memorial Sloane Kettering Cancer Center.

18 Nov 2014

IntelliCap electronic oral drug delivery technology wins prestigious European ‘High-Tech Innovation Award’

The IntelliCap electronic oral drug delivery technology, created by medtech innovator Medimetrics, has won a prestigious European ‘High-Tech Innovation Award’ from Accenture, the global management consultancy.

18 Nov 2014

Pros and cons of medical marijuana to be discussed at Queensland Epilepsy Symposium

The pros and cons of medical marijuana is a discussion focus at the fifth annual Queensland Epilepsy Symposium, Epilepsy – On the Horizon.

18 Nov 2014

Scientists identify defects in colossal heart protein which leads to stroke, heart failure

The landmark discovery of a tiny defect in a vital heart protein has for the first time enabled heart specialists to accurately pinpoint a therapeutic target for future efforts in developing a drug-based cure for cardiovascular diseases.

18 Nov 2014

VEGF-B can regenerate damaged peripheral nerves without causing growth of new blood vessels

Researchers at the University of Illinois at Chicago College of Medicine have found that a growth factor can regenerate damaged peripheral nerves without causing the growth of new blood vessels -- making it a unique candidate to treat nerve damage in areas of the body where the proliferation of blood vessels would be a drawback.

18 Nov 2014

Asthma associated with higher risk of heart attack or stroke

Asthma that requires daily medication is associated with a significantly higher risk of heart attack or stroke, according to a new study from the University of Wisconsin School of Medicine and Public Health.

18 Nov 2014

New look at the workings of HIV, other viruses

UC Davis researchers are getting a new look at the workings of HIV and other viruses thanks to new techniques in electron microscopy developed on campus.

18 Nov 2014

Curcumin and tackling mesothelioma: an interview with Dr. Afshin Dowlati

An important point about this work is that the research into curcumin was conducted following a discovery about mesothelioma, rather than being the primary endpoint of the study.

17 Nov 2014

Study suggests that beta blockers may benefit patients suffering from HFPEF

A novel registry study from Karolinska Institutet in Sweden suggests that beta blockers may benefit also patients suffering from a relatively unknown form of heart failure called HFPEF, which today lacks well-established treatment.

17 Nov 2014

UT Southwestern researchers identify new gene mutations involved in certain kidney cancers

Using next generation gene sequencing techniques, cancer researchers at UT Southwestern Medical Center have identified more than 3,000 new mutations involved in certain kidney cancers, findings that help explain the diversity of cancer behaviors.

17 Nov 2014

NIH study finds limited kidney benefit from more rigorous blood pressure treatment

Using two drugs was no more effective than a single drug in slowing disease progression in people with autosomal dominant polycystic kidney disease (ADPKD), according to two studies funded by the National Institutes of Health. One of the studies also showed that rigorous blood pressure treatment slowed growth of kidney cysts, a marker of ADPKD, but had little effect on kidney function compared to standard blood pressure treatment.

17 Nov 2014

Sanofi, Genzyme announce FDA approval of Lemtrada for treatment of relapsing forms of MS

Sanofi and its subsidiary Genzyme announced today that the U.S. Food and Drug Administration has approved Lemtrada (alemtuzumab) for the treatment of patients with relapsing forms of multiple sclerosis (MS). Because of its safety profile, the use of Lemtrada should generally be reserved for patients who have had an inadequate response to two or more drugs indicated for the treatment of MS.

17 Nov 2014

Spinal cord injuries can cause brain degeneration, find UM SOM researchers

Most research on spinal cord injuries has focused on effects due to spinal cord damage and scientists have neglected the effects on brain function. University of Maryland School of Medicine researchers have found for the first time that spinal cord injuries (SCI) can cause widespread and sustained brain inflammation that leads to progressive loss of nerve cells, with associated cognitive problems and depression.

17 Nov 2014

Prostate cancer patients with hereditary BRCA mutations respond less well to conventional treatment

Prostate cancer patients carrying inherited mutations in the BRCA genes respond less well to conventional treatment, including surgery and/or radiotherapy - and they also have a lower survival rate than those who are non-carriers of these genetic mutations. Data from the study, which has been published in the journal European Urology, points to the need for new clinical trials aimed at targeting these mutations in order to tailor treatment for these patients.

17 Nov 2014

Understanding the genetic basis of glaucoma

Scientists from the University of Liverpool have sequenced the mitochondrial genome in glaucoma patients to help further understanding into the genetic basis for the disease.

16 Nov 2014

UNC researchers develop new approach to block KRAS oncogene

Researchers from the UNC School of Medicine and colleagues at The University of Texas MD Anderson Cancer Center have developed a new approach to block the KRAS oncogene, one of the most frequently mutated genes in human cancer.

14 Nov 2014

Drugs News and Research

Health Canada to review evidence on the safety of long-term use of prescription blood-thinners

Zytiga is commonly prescribed for second-line treatment of mCRPC patients

Study identifies new gene for progressive form of epilepsy

New research suggests potential role for MEK inhibitors in type 2 diabetes

FDA grants Orphan Drug Designation to Juno's JCAR015 leukemia T cell product candidate

IntelliCap electronic oral drug delivery technology wins prestigious European ‘High-Tech Innovation Award’

Pros and cons of medical marijuana to be discussed at Queensland Epilepsy Symposium

Scientists identify defects in colossal heart protein which leads to stroke, heart failure

VEGF-B can regenerate damaged peripheral nerves without causing growth of new blood vessels

Asthma associated with higher risk of heart attack or stroke

New look at the workings of HIV, other viruses

Curcumin and tackling mesothelioma: an interview with Dr. Afshin Dowlati

Study suggests that beta blockers may benefit patients suffering from HFPEF

UT Southwestern researchers identify new gene mutations involved in certain kidney cancers

NIH study finds limited kidney benefit from more rigorous blood pressure treatment

Sanofi, Genzyme announce FDA approval of Lemtrada for treatment of relapsing forms of MS

Spinal cord injuries can cause brain degeneration, find UM SOM researchers

Prostate cancer patients with hereditary BRCA mutations respond less well to conventional treatment

Understanding the genetic basis of glaucoma

UNC researchers develop new approach to block KRAS oncogene

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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