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Three MGH projects named among Top 10 Clinical Research Achievements of 2012

Three projects led by Massachusetts General Hospital investigators have been named among the Clinical Research Forum's Top 10 Clinical Research Achievements of 2012.

19 Apr 2013

HUGO recognizes Dr. Patrick Tan for research on genomic profiles of Asian cancers

Dr Patrick Tan from A*STAR's Genome Institute of Singapore has received the 2013 Chen New Investigator Award from the international Human Genome Organisation.

19 Apr 2013

Abnormal protein translation leads to Fragile X ataxia, study finds

A bizarre twist on the usual way proteins are made may explain mysterious symptoms in the grandparents of some children with mental disabilities.

19 Apr 2013

SCCA pioneers new transplant procedures to reduce need for matching bone marrow donors

Patients from ethnic minority and mixed-racial backgrounds are less likely to receive a lifesaving bone marrow transplant than Caucasian patients with the same disease due to lack of matching donors, according to the National Marrow Donor Program.

19 Apr 2013

Content of exosomes mirrors aggressiveness of brain tumour, study shows

"Current wisdom says that cells are closed entities that communicate through the secretion of soluble signalling molecules. Recent findings indicate that cells can exchange more complex information - whole packages of genetic material and signalling proteins.

19 Apr 2013

Research shows how breakdowns in DNA copying process contribute to cancer

Research led by a scientist at the University of York has thrown new light on the way breakdowns in the DNA copying process inside cells can contribute to cancer and other diseases.

19 Apr 2013

North American scientists chart new territory in immunity research

Cracking the DNA code for a complex region of the human genome has helped 14 North American scientists, including five at Simon Fraser University, chart new territory in immunity research.

19 Apr 2013

Researchers study new ways of taking advantage of caffeine's lethal effects on cancer cells

Researchers from the University of Alberta are abuzz after using fruit flies to find new ways of taking advantage of caffeine's lethal effects on cancer cells-results that could one day be used to advance cancer therapies for people.

19 Apr 2013

Research findings provide new hope for people suffering from dry eye disease

Natural lubricants play an important role in health, including a well-known effect to help prevent osteoarthritis in knee and ankle joints. However, much is still unknown about their role and function in other areas of the body.

19 Apr 2013

Study highlights how genes can acquire, adapt to different roles in human evolution

Researchers have designed a method that can universally test for evolutionary adaption, or positive (Darwinian) selection, in any chosen set of genes, using re-sequencing data such as that generated by the 1000 Genomes Project.

19 Apr 2013

Tel Aviv University researcher reveals the missing link between brain patterns and Alzheimer's

Evidence indicates that the accumulation of amyloid-beta proteins, which form the plaques found in the brains of Alzheimer's patients, is critical for the development of Alzheimer's disease, which impacts 5.4 million Americans.

19 Apr 2013

Three missense variants of BRCA1 gene linked to breast or ovarian cancer risk, study shows

Researchers of the hereditary cancer research group at the Bellvitge Biomedical Research Institute and the Catalan Institute of Oncology conducted a functional and structural study of seven missense variants of the BRCA1 gene concluding that three of these variants are pathogenic, linked to the risk of suffering breast or ovarian cancer.

19 Apr 2013

Research: Gene behind epilepsy syndrome could play a key role in other idiopathic epilepsies

Researchers at the University Department of Neurology at the MedUni Vienna have identified a gene behind an epilepsy syndrome, which could also play an important role in other idiopathic (genetically caused) epilepsies.

18 Apr 2013

Study highlights importance of zebrafish as a model organism for human disease research

Researchers demonstrate today that 70 per cent of protein-coding human genes are related to genes found in the zebrafish and that 84 per cent of genes known to be associated with human disease have a zebrafish counterpart.

18 Apr 2013

ARMGO Pharma gets $1 million to support ARM210 preclinical work for DMD treatment

ARMGO Pharma and the Muscular Dystrophy Association today announced that $1 Million has been awarded for preclinical work in support of an Investigational New Drug application with the U.S. Food and Drug Administration for ARM210, a novel, orally available, small-molecule Rycal drug that has potential as a treatment for Duchenne muscular dystrophy.

18 Apr 2013

CRISPR helps some bacteria evade mammalian immune system

CRISPR, a system of genes that bacteria use to defend themselves against viruses, has been found to be involved in helping some bacteria evade the mammalian immune system.

18 Apr 2013

Findings hold promise for development of therapies to fight different viral infections

The human body has the ability to ward off viruses by activating a naturally occurring protein at the cellular level, setting off a chain reaction that disrupts the levels of cholesterol required in cell membranes to enable viruses to enter cells.

18 Apr 2013

New pre-clinical study suggests novel drug combination therapy for leukemia treatment

A new, pre-clinical study by researchers at Virginia Commonwealth University Massey Cancer Center suggests that a novel drug combination could lead to profound leukemia cell death by disrupting the function of two major pro-survival proteins.

18 Apr 2013

Researchers find potential new genetic chemotherapy approach for cancer treatment

Researchers at The Jackson Laboratory have identified a molecule that prevents repair of some cancer cells, providing a potential new "genetic chemotherapy" approach to cancer treatment that could significantly reduce side effects and the development of treatment resistance compared with traditional chemotherapy.

18 Apr 2013

Examining function of all genes in zebrafish genome could benefit human health, researchers say

Equipped with the zebrafish genome, researchers have designed a method to assay the function of each and every gene and to explore the effects genetic variation has on zebrafish.

18 Apr 2013

Genetic News and Research

Three MGH projects named among Top 10 Clinical Research Achievements of 2012

HUGO recognizes Dr. Patrick Tan for research on genomic profiles of Asian cancers

Abnormal protein translation leads to Fragile X ataxia, study finds

SCCA pioneers new transplant procedures to reduce need for matching bone marrow donors

Content of exosomes mirrors aggressiveness of brain tumour, study shows

Research shows how breakdowns in DNA copying process contribute to cancer

North American scientists chart new territory in immunity research

Researchers study new ways of taking advantage of caffeine's lethal effects on cancer cells

Research findings provide new hope for people suffering from dry eye disease

Study highlights how genes can acquire, adapt to different roles in human evolution

Tel Aviv University researcher reveals the missing link between brain patterns and Alzheimer's

Three missense variants of BRCA1 gene linked to breast or ovarian cancer risk, study shows

Research: Gene behind epilepsy syndrome could play a key role in other idiopathic epilepsies

Study highlights importance of zebrafish as a model organism for human disease research

ARMGO Pharma gets $1 million to support ARM210 preclinical work for DMD treatment

CRISPR helps some bacteria evade mammalian immune system

Findings hold promise for development of therapies to fight different viral infections

New pre-clinical study suggests novel drug combination therapy for leukemia treatment

Researchers find potential new genetic chemotherapy approach for cancer treatment

Examining function of all genes in zebrafish genome could benefit human health, researchers say

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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