Atherosclerosis News and Research

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Atherosclerosis is the progressive buildup of plaque - the fatty deposits and other cells - in the inner walls of the arteries. The condition is a consequence of elevated cholesterol and for many it's a silent disease, with no visible signs or symptoms. The disease can begin in early adulthood and continues to progress for the rest of a person's life. Despite the serious nature of atherosclerosis, many people do not understand how it develops and progresses.

Rimonabant shows mixed results for slowing progression of coronary disease

The anti-obesity medication rimonabant showed mixed results in slowing progression of coronary artery disease in patients with abdominal obesity and pre-existing coronary disease, according to a new study in the April 2 issue of JAMA.

2 Apr 2008

Chloroform provides clue to 150 year old medical puzzle

One of the earliest general anaesthetics to be used by the medical profession, chloroform, has shed light on a mystery that's puzzled doctors for more than 150 years - how such anaesthetics actually work.

1 Apr 2008

Study shows Actos prevented progression of atherosclerotic plaque volume in patients

New data from a clinical trial using intravascular ultrasound (IVUS) technology found that in patients living with type 2 diabetes, ACTOS (pioglitazone HCl) reduced the atherosclerotic burden in the coronary arteries compared to glimepiride, and prevented progression compared to baseline.

1 Apr 2008

FDA makes recommendations on medical devices that treat blocked heart arteries

U.S. Food and Drug Administration Commissioner Andrew C. von Eschenbach has announced that the agency has issued draft guidelines to aid the development, testing and manufacture of coronary drug-eluting stents, devices used to treat blocked heart arteries.

28 Mar 2008

Cardiovascular and metabolic issues in patients with thyroid dysfunction

Thyroid experts will present the latest information on cardiovascular and metabolic issues in patients with thyroid disorders, including those who have an underactive thyroid (hypothyroidism) or an overactive thyroid (hyperthyroidism), at a day-long scientific meeting on Friday, March 28, 2008 at the Marriott Metro Center in Washington, DC.

26 Mar 2008

Severe psoriasis linked to serious medical conditions including cardiovascular disease, depression and cancer

It has long been known that psoriasis, a chronic skin condition characterized by thick, red, scaly plaques that itch and bleed, can have a significant negative impact on a patient's overall quality of life.

25 Mar 2008

NicOx signs agreement for commercial manufacture of Naproxcinod drug substance

NicOx S.A. (Euronext Paris: COX) has announced it has signed an agreement with the fine chemical company Archimica, for the commercial manufacturing and supply of naproxcinod drug substance (or active pharmaceutical ingredient, API).

20 Mar 2008

Hispanics with clogged arteries at greatest risk of stroke, heart attack

Hispanics who have even a small amount of plaque build-up in the neck artery that supplies blood to the brain are up to four times more likely to suffer or die from a stroke or heart attack than Hispanics who do not have plaque, according to a study published in the March 19, 2008, online issue of Neurology, the medical journal of the American Academy of Neurology.

20 Mar 2008

HDL-associated protein gene linked to heart disease risk

The gene for the HDL-associated protein paraoxonase 1 (PON1) appears to be associated with coronary artery disease and with the risk of developing adverse cardiac events, and variations in both the PON1 gene and its related enzyme activity may increase the risk for cardiovascular disease events, according to a study in the March 19 issue of JAMA , a theme issue on Genetics and Genomics.

19 Mar 2008

Genes that protect against atherosclerosis identified

One way of combating atherosclerosis is to reduce levels of “bad cholesterol” in the blood. Scientists at the Swedish medical university Karolinska Institutet have now identified the genes that bring about this beneficial effect.

17 Mar 2008

Toddlers affected most by secondhand smoke exposure at home

Secondhand smoke in the home appears to induce markers for heart disease as early as the toddler years, researchers reported at the American Heart Association's 48th Annual Conference on Cardiovascular Disease Epidemiology and Prevention.

14 Mar 2008

How diabetes drives atherosclerosis

Researchers have discovered how diabetes, by driving inflammation and slowing blood flow, dramatically accelerates atherosclerosis, according to research to be published in the March 14 edition of the journal Circulation Research. Experts once believed that atherosclerosis, or hardening of the arteries, developed when too much cholesterol clogged arteries with fatty deposits called plaques.

14 Mar 2008

Turning off rogue macrophages

University of Pennsylvania scientists studying macrophages, the biological cells that spring from white blood cells to eat and destroy foreign or dying cells, have discovered how these "policemen" differentiate between friend and foe.

12 Mar 2008

Long-term effects of synthetic progestins cause for concern

The widely used synthetic progestin medroxyprogesterone acetate (MPA) decreased endothelial function in premenopausal women in a study done at the University of Oregon.

11 Mar 2008

A glass of wine a day protects middle-aged teetotallers from heart disease

Scientists say that middle-aged 'teetotallers' can quickly reduce their risk of heart disease by having a daily tipple.

10 Mar 2008

Researchers discover molecular pathway in blood vessels that controls blood pressure and vascular function

University of Iowa researchers have identified a molecular pathway in blood vessels that controls blood pressure and vascular function and may help explain why certain drugs for type II diabetes also appear to lower patients' blood pressure.

6 Mar 2008

New potential drug target for atherosclerosis

A nuclear receptor protein, known for controlling the ability of cells to burn fat, also exerts powerful anti-inflammatory effects in arteries, suppressing atherosclerosis in mice prone to developing the harmful plaques, according to new research by scientists at the Salk Institute for Biological Studies and the Harvard School of Public Health.

6 Mar 2008

Low-fat better than low-carb diets for heart health

Low-fat diets are more effective in preserving and promoting a healthy cardiovascular system than low-carbohydrate, Atkins'-like diets, according to a new study by researchers at the Medical College of Wisconsin in Milwaukee.

1 Mar 2008

New Alzheimer's patent by Affiris

Affiris GmbH has secured another Europe-wide patent for an innovative method of treating Alzheimer's disease. This new blood-cleansing method is similar to dialysis and is designed to reduce the amount of harmful protein deposits in the brain. It is based on the AFFITOME technology established by Affiris, which was patented in October 2007 for an Alzheimer's vaccine.

27 Feb 2008

Despite advances, atherosclerosis solution is years away

It's the leading cause of heart disease and stroke: atherosclerosis - a disease characterized by the thickening of arterial walls, restricting blood flow like a narrow pipe.

21 Feb 2008