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How a single mutation can devastate cellular function

A scientist has shown how a single mutation in a protein found in astrocytes reproduces fibrous globs that devastate cellular function.

23 Oct 2018

New type of molecule shows early promise against treatment-resistant prostate cancer

A new type of molecule blocks the action of genes that drive the growth of therapy-resistant prostate cancer, a new study finds.

23 Oct 2018

Patient Outcomes of Prostate Cancer with Whole Slide Imaging

An interview with Dr.

From Huron Technologies 23 Oct 2018

Study uncovers new mechanism of action in a first-line drug for diabetes

For decades, metformin has been the first-line drug in the treatment of type 2 diabetes, lowering blood glucose levels by inhibiting glucose production in the liver. Metformin also improves glucose uptake and use by muscle tissue.

23 Oct 2018

Advanced breast cancer patients can benefit from immunotherapy-chemotherapy combination

Patients with an aggressive form of advanced breast cancer can benefit from immunotherapy when used in combination with chemotherapy as first-line treatment, according to the results of a large international Phase III clinical trial published today in the New England Journal of Medicine and led by a researcher at the UPMC Hillman Cancer Center and the University of Pittsburgh School of Medicine.

23 Oct 2018

Knowledge of sex differences in lower urinary tract may help stimulate breakthroughs in diagnosis, management

The biological differences between women and men go beyond basic anatomy. Researchers must consider sex differences down to the cellular level in order to discover crucial information about the varied development, function, and biology between women and men.

23 Oct 2018

Forbius initiates Phase 2a trial evaluating efficacy, safety of AVID100 in patients with squamous NSCLC

Forbius, a clinical stage company developing biotherapeutics targeting EGFR and TGF-β pathways, today announced that the first patient has been dosed in a Phase 2a trial evaluating the efficacy and safety of AVID100 in patients with squamous non-small cell lung cancer whose tumors overexpress epidermal growth factor receptor.

23 Oct 2018

Scientists discover primary, direct target of alcohol in the brain

When alcohol enters the brain, it causes neurons in a specialized region called the ventral tegmental area, or VTA -- also known as the "pleasure center" -- to release dopamine, a neurotransmitter that produces those feel-good sensations, and tells the brain that whatever it just experienced is worth getting more of.

23 Oct 2018

Map of human liver cells reveals molecular make-up of individual cells

A map of the cells in the human liver has been created by University Health Network Transplant Program and University of Toronto researchers, revealing for the first time differences between individual cells at the molecular level which can have a profound impact on their behaviour in tissue, tumours and disease.

From 10x Genomics, Inc. 23 Oct 2018

SLU researcher seeks to find solutions for 'chemo brain' symptoms and side effects of opioids

With a pair of RO1 grants from the National Institutes of Health, pain researcher Daniela Salvemini, Ph.D., will embark on two new research projects, studying chemotherapy-induced cognitive impairment, or "chemo brain," symptoms and unwanted side effects of opioids.

23 Oct 2018

New approach may lead to better diagnostic techniques for autoimmune disorders

If we really want to know how our body's cells work - or don't work, in the case of disease - we might need to look beyond their genes and even beyond the proteins they are made of.

23 Oct 2018

NCI grant awarded to Abramson Cancer Center to study CAR T cells In solid tumors

A new program project grant from the National Cancer Institute will fund research by the Translational Center of Excellence for Lung Cancer Immunology at the Abramson Cancer Center of the University of Pennsylvania to improve the effectiveness of chimeric antigen receptor T cell therapy at fighting solid tumors.

23 Oct 2018

New topical gel can prevent pesticide-induced toxicity and lethality

Farmers are exposed to toxic pesticides, through skin contact and inhalation, during the spraying of pesticides. This is a severe health hazard. In the last year, from the Vidharbha region in Maharashtra alone, spraying is thought to have led to over 40 deaths, 25 cases of lost vision, and over 1000 hospitalizations.

22 Oct 2018

Innovative strategy opens up new avenue of treatment for anthrax infections

A team led by Professor Arne Skerra at the Technical University of Munich has developed an innovative strategy for preventing the anthrax bacterium from absorbing iron, which is crucial for its survival.

22 Oct 2018

Paternal exercise has significant impact on child's lifelong metabolic health

Recent studies have linked development of type 2 diabetes and impaired metabolic health individuals to their parents' poor diet, and there is increasing evidence that fathers play an important role in obesity and metabolic programming of their offspring.

22 Oct 2018

Drug cocktail that increases lifespan discovered

A team of researchers led by Principal Investigator Dr Jan Gruber from Yale-NUS College has discovered a combination of pharmaceutical drugs that not only increases healthy lifespan in the microscopic worm Caenorhabditis elegans (C. elegans), but also delays the rate of ageing in them, a finding that could someday mean longer, healthier lives for humans.

22 Oct 2018

Researchers discover new structure in human cells

A new structure in human cells has been discovered by researchers at Karolinska Institutet in Sweden in collaboration with colleagues in the UK.

22 Oct 2018

New protein sequencing technique could revolutionize biomedical research

Scientists have developed a new, low-throughput technique that allows individual proteins to be identified. It is called single molecule fluorosequencing.

22 Oct 2018

Immunotherapy achieves major pathological response in early-stage mismatch repair deficient colon cancer

Pre-operative treatment with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab achieves major pathological responses in 100% of early-stage colon cancers with mismatch repair deficiencies, according to results reported at ESMO 2018 from the first exploratory phase II trial to investigate this approach.

22 Oct 2018

IDT to demonstrate CRISPR expertise at European-focused events

As an advocate for the genomics age, Integrated DNA Technologies (IDT), will showcase its renowned CRISPR expertise at a series of European-focused events.

From Integrated DNA Technologies 22 Oct 2018