Animal Model News and Research

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In monkeys, spike-based vaccines produce some immunity based on CD8 T-cells

Scientists evaluate the role of CD8+ T-cells in vaccine protection against SARS-CoV-2 infection in rhesus macaques.

14 Aug 2022

How effective is tecovirimat as a treatment against monkeypox?

A new study evaluated the use of tecovirimat for monkeypox treatment during the current outbreak.

9 Aug 2022

Gait analysis in animals: Treadmill versus non treadmill system

This interview will look into talking about different systems used for analyzing gait in animals, in treadmill versus non-treadmill systems.

From Noldus Information Technology 8 Aug 2022

Study: SARS-CoV-2 variants of concern and biological sex of patients affect molnupiravir efficacy

SARS-CoV-2 variants of concern and the biological sex of patients affect the efficacy of molnupiravir, the first orally available drug approved for outpatient use against COVID-19, according to a new study led by researchers in the Center for Translational Antiviral Research in the Institute for Biomedical Sciences at Georgia State University.

1 Aug 2022

Incorporating a coronavirus antigen into MMR vaccine to produce COVID-19 immunity in kids

New research has advanced COVID-19 vaccine work in several ways: using a modified live attenuated mumps virus for delivery, showing that a more stable coronavirus spike protein stimulates a stronger immune response, and suggesting a dose up the nose has an advantage over a shot.

27 Jul 2022

Doggybone DNA COVID-19 vaccine can effectively neutralize SARS-CoV-2 variants

Researchers assessed the efficacy of the novel SARS-CoV-2 doggybone deoxyribonucleic acid (DNA) vaccine.

13 Jul 2022

Study establishes a transformative approach to studying perceptual learning in the brain

Our visual perception of the world is often thought of as relatively stable. However, like all of our cognitive functions, visual processing is shaped by our experiences.

8 Jul 2022

Study finds microglia to be responsible for neuronal death in a mitochondrial disease animal model

Microglia, a type of central nervous system cell, is primarily responsible for neuronal death in Leigh Syndrome and the neurological symptoms related to this mitochondrial disease.

8 Jul 2022

New non-invasive treatment for patients suffering from treatment-resistant depression and dementia

A joint research team from the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) and City University of Hong Kong (CityU) has discovered that the electrical stimulation of the eye surface can alleviate depression-like symptoms and improve cognitive function in animal models.

8 Jul 2022

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

A recent study published in the Science journal depicted that mosaic receptor-binding domain (RBD) nanoparticles immunize from diverse sarbecovirus challenges, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), among animal models.

8 Jul 2022

Novel COVID-19 antibody delivery approach advances to clinical trials

Under a Defense Advanced Research Projects Agency (DARPA) and Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND) funded program, a novel COVID-19 antibody delivery approach has advanced to clinical trials.

7 Jul 2022

Study: Lactobacilli living in female urinary tract's microbiome can kill nearby pathogenic bacteria

Lactobacilli that live in the human female urinary tract's microbiome are competitive and kill nearby pathogenic bacteria, according to the first study of its kind by a team led by microbiologist Dr. Tanya Sysoeva of The University of Alabama in Huntsville.

6 Jul 2022

Genetically engineered kidney organoids solve mystery of a rare disease

Researchers have solved a medical mystery in a poorly understood disease by uncovering which cells cause tumors in patients with tuberous sclerosis complex (TSC).

6 Jul 2022

Gene defect underlying Krabbe disease causes degeneration of neurons directly, study finds

The gene defect underlying Krabbe disease causes degeneration of neurons directly, independent of its effects on other cell types, according to a new study publishing July 5th in the open-access journal PLOS Biology by Daesung Shin of the University at Buffalo, U.S. and colleagues.

5 Jul 2022

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

The viral replication cycle is crucial for a virus to spread inside the body and cause disease. Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) polymerases.

4 Jul 2022

Comprehensive atlas of genetic data on zebrafish will benefit medical and life science researchers

Medical and life science researchers will benefit from the most comprehensive atlas yet of genetic data on zebrafish, newly published research suggests.

4 Jul 2022

Combining AI and Zebrafish to Accelerate Drug Discovery

As part of our SLAS Europe 2022 coverage, we speak to Dr. Javier Terriente, Co-founder and Chief of Drug Development at ZeClinics, about how zebrafish could be the future for discovering new therapeutics.

From Society for Laboratory Automation and Screening (SLAS) 1 Jul 2022

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

Lamivudine, a commonly-used antiretroviral drug for treating HIV, improves cognition in a mouse model of Down syndrome, according to the findings of a joint new study by researchers at the Centre for Genomic Regulation (CRG) and the IrsiCaixa AIDS Research Institute, a center jointly promoted by the "la Caixa" Foundation and the Department of Health of the Generalitat de Catalunya.

28 Jun 2022

COVID-19 can cause metabolism problems by interfering with insulin signaling, study reveals

It has become abundantly clear that coronavirus disease 19 (COVID-19), despite being transmitted by breathing in the SARS-CoV-2 virus, can have harmful effects far beyond the lungs.

27 Jun 2022

Listeria-based booster vaccine strategy offers improved protection against recurrent colorectal cancer

Colorectal, pancreatic, esophageal and stomach cancers-;some of the deadliest kinds of cancer-; have high recurrence rates where the cancer comes back even after successful surgery or radiation treatment.

23 Jun 2022

Animal Model News and Research

In monkeys, spike-based vaccines produce some immunity based on CD8 T-cells

How effective is tecovirimat as a treatment against monkeypox?

Gait analysis in animals: Treadmill versus non treadmill system

Study: SARS-CoV-2 variants of concern and biological sex of patients affect molnupiravir efficacy

Incorporating a coronavirus antigen into MMR vaccine to produce COVID-19 immunity in kids

Doggybone DNA COVID-19 vaccine can effectively neutralize SARS-CoV-2 variants

Study establishes a transformative approach to studying perceptual learning in the brain

Study finds microglia to be responsible for neuronal death in a mitochondrial disease animal model

New non-invasive treatment for patients suffering from treatment-resistant depression and dementia

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

Novel COVID-19 antibody delivery approach advances to clinical trials

Study: Lactobacilli living in female urinary tract's microbiome can kill nearby pathogenic bacteria

Genetically engineered kidney organoids solve mystery of a rare disease

Gene defect underlying Krabbe disease causes degeneration of neurons directly, study finds

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

Comprehensive atlas of genetic data on zebrafish will benefit medical and life science researchers

Combining AI and Zebrafish to Accelerate Drug Discovery

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

COVID-19 can cause metabolism problems by interfering with insulin signaling, study reveals

Listeria-based booster vaccine strategy offers improved protection against recurrent colorectal cancer

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

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