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Inflammation in mid-life may be linked to brain shrinkage decades later

People who have biomarkers tied to inflammation in their blood in their 40s and 50s may have more brain shrinkage decades later than people without the biomarkers, according to a study published in the November 1, 2017, online issue of Neurology, the medical journal of the American Academy of Neurology. The brain cell loss was found especially in areas of the brain that are affected by Alzheimer's disease.

2 Nov 2017

Wake Forest Baptist receives NIH grants to study risks associated with kidney transplants

The National Institutes of Health has awarded two five-year grants to Wake Forest Baptist Medical Center worth more than $5 million to prospectively study the effects of a genetic variation in organ donors that appears to contribute to survival of kidneys after transplantation.

3 Oct 2017

Impairing critical partnership between brain cells can lead to Alzheimer's disease

Researchers have discovered that impairing a critical partnership between brain cells can lead to neurodegeneration. The study published in Cell Metabolism reports a mechanism by which two types of brain cells, neurons and glia, normally support each other's functions.

30 Sep 2017

Decreasing sedentary time 21 minutes per day can help maintain muscle mass, health

Finnish researchers conducted one of the largest and longest studies to find out if it is possible to reduce sedentary time and if the reduction will result in any health benefits during one year.

30 Aug 2017

Moderate intake of carbohydrate and fat associated with better health, says global study

An international study suggests that a diet consisting of a moderate consumption of fat, fruits and vegetables, coupled with avoidance of high levels of carbohydrates, is linked with a decreased risk of death.

30 Aug 2017

Moderate intake of nutrients found to be best for health

Research with more than 135,000 people across five continents has shown that a diet which includes a moderate intake of fat and fruits and vegetables, and avoidance of high carbohydrates, is associated with lower risk of death.

29 Aug 2017

Clinical benefit of LDL cholesterol lowering therapies could depend on reduction in apoB particles

The benefit of lowering low-density lipoprotein (LDL) cholesterol depends on how it is lowered, according to late-breaking results from a naturally randomised genetic trial presented today in a Hot Line - LBCT Session at ESC Congress1 and published in JAMA.

29 Aug 2017

Studies aim to better understand potential health benefits of red raspberries

Initial findings from several studies - including both human subjects and animals - on the potential health benefits of red raspberries were presented earlier this year at the 2017 Experimental Biology conference in Chicago.

24 Aug 2017

People with genetic susceptibility to Alzheimer's may have greater cognitive deficits with sleep-disordered breathing

People who carry a genetic susceptibility to Alzheimer's disease appear to be at greater risk of diminished cognition from sleep-disordered breathing than those without the susceptibility, according to new research published online, ahead of print in the Annals of the American Thoracic Society.

21 Jul 2017

Targeting risk factors throughout life stages could prevent 35% of dementia cases, study reveals

A study published in The Lancet, on July 20th 2017, reveals that 1 out of 3 dementia cases are preventable when risk factors are targeted beginning from childhood.

20 Jul 2017

E-Scape Bio announces extension of funding to develop novel drug for Alzheimer's disease

E-Scape Bio announced an extension of its Series A funding to a total of $63 million. Created as a spin-off from research conducted at the Gladstone Institutes, E-Scape Bio is a biopharmaceutical company with a mission to develop new therapies to treat neurodegenerative disorders such as Alzheimer's disease.

12 Jul 2017

Elevated levels of suPAR protein combine with genetic mutation to trigger CKD in black people

Between 15 and 20 percent of black people carry a genetic mutation that puts them at risk for certain chronic kidney disease, but only about half of them develop the illness – a variance that long has puzzled researchers.

27 Jun 2017

Poor diet may fuel Alzheimer's in people who carry disease-related gene

A diet high in cholesterol, fat and sugar may influence the development of Alzheimer's disease in people who carry the ApoE4 gene, a leading risk factor for the memory-erasing disease, indicates a new USC study.

13 Jun 2017

Vascular risk factors increase risk of Alzheimer's disease in late-life, study reveals

A study published in The Journal of the American Medical Association (JAMA) reveals that an increasing number of vascular risk factors such as obesity, high blood pressure, diabetes, high cholesterol, and smoking during midlife contributes to increased brain amyloid levels (protein fragments associated with Alzhemier’s, the most common form of dementia) in later life.

13 Apr 2017

CUMC researchers discover common genetic variant that impacts brain aging

Columbia University Medical Center researchers have discovered a common genetic variant that greatly impacts normal brain aging, starting at around age 65, and may modify the risk for neurodegenerative diseases.

15 Mar 2017

Study could help doctors to better predict development of cardiovascular disease at earlier stage

Screening methods for cardiovascular diseases such as heart attacks and strokes could be improved by measuring different biological signposts to those currently being tested, a new study led by researchers from King's College London suggests.

21 Feb 2017

Mentally stimulating activities may decrease risk of developing mild cognitive impairment, study finds

Mayo Clinic researchers have found that engaging in mentally stimulating activities, even late in life, may protect against new-onset mild cognitive impairment, which is the intermediate stage between normal cognitive aging and dementia.

30 Jan 2017

Selonterra publishes article on novel APOE4 mechanism linked to Alzheimer’s disease

Selonterra LLC, a biotechnology company discovering therapies for Alzheimer’s disease and Parkinson’s disease announced the publication of the article “Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer’s Disease” in Scientific Reports, a peer-reviewed journal of the Nature Publishing Group.

19 Jan 2017

'Dementia gene' may offer protection against cognitive decline linked to parasitic diseases

New research published online in The FASEB Journal, suggests that carriers of the Apolipoprotein E4 allele, which is the single strongest genetic predictor of Alzheimer's disease and is associated with cognitive decline and cardiovascular disease, may have a reduced risk of cognitive decline associated with parasitic diseases.

11 Jan 2017

Sedentary older adults likely to develop dementia as those with genetic risk factors, research finds

Sedentary older adults with no genetic risk factors for dementia may be just as likely to develop the disease as those who are genetically predisposed, according to a major study which followed more than 1,600 Canadians over five years.

10 Jan 2017