Apolipoprotein News and Research

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Early life adversity linked to accelerated neurobiological aging, raising vulnerability to depression and Alzheimer's

scientists investigate the neurocognitive correlates of genetic vulnerability to major depressive disorder and Alzheimer's disease.

30 Mar 2023

New review examines link between HDLC and different types of cancer

Researchers summarized studies on the association between high-density lipoprotein cholesterol and different types of cancer

29 Mar 2023

Fiber intake associated with lower risk of cognitive decline in old people with ApoE ε4 genotype

Fiber intake is associated with a lower risk of developing cognitive decline in those old people with the Apolipoprotein E ApoE ε4 genotype, regarded as a genetic risk factor linked to the development of Alzheimer's disease.

22 Mar 2023

Reversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein

Houston Methodist scientists reversed infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein, showing further evidence that links high cholesterol to female infertility.

15 Mar 2023

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

MK-0616, an experimental oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, met its primary endpoint and substantially reduced levels of low-density lipoprotein (LDL) cholesterol in people with high cholesterol and/or heart disease related to clogged arteries, in a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Keto-like diet may be associated with elevated risk of cardiovascular events

The ketogenic or "keto" diet, which involves consuming very low amounts of carbohydrates and high amounts of fats, has been gaining popularity.

5 Mar 2023

Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Researchers performed multi-organ single-cell RNA sequencing of collagen-induced arthritis murine model to evaluate immune-mediated inflammatory disease alterations by characterizing the genome, organizing the organome, and prioritizing pathways in the multi-organ data.

3 Mar 2023

Research investigates roles of neurotrophic factors on cognition in Alzheimer's patients carrying APOE ε4

Researchers investigate the role of neurotrophic factors on the cognitive performance of Alzheimer’s disease patients carrying the apolipoprotein E 4 gene.

1 Mar 2023

Apolipoprotein E4 promotes the development of Alzheimer’s disease

Researchers characterize the effects of neuronal apolipoprotein E4 on Alzheimer’s disease-associated pathology.

23 Feb 2023

Study reports that depleting gut bacteria in mice with genetic risk for AD reduces neuropathology in a sex-dependent manner

Researchers highlight recent research investigating whether gut microbiota regulates tau pathology and tau-mediated neurodegeneration in an ApoE isoform–dependent manner.

21 Feb 2023

Can carbohydrate be reduced too low for weight loss, and glycemic control?

A new review in the Journal of Clinical Lipidology aimed to describe the definitions of carbohydrate-restricted dietary patterns, the potential benefits related to cardiometabolic risk factors, and whether healthcare professionals should consider it for glycemic management and weight loss.

9 Feb 2023

Study demonstrates intrahost MPXV variation within a single lesion

Researchers reported on the clinical and molecular characteristics of MPXV infections in Finland.

31 Jan 2023

Study of older adults in China finds link between a healthy lifestyle and slower memory decline

A healthy lifestyle, in particular a healthy diet, is associated with slower memory decline, finds a decade-long study of older adults in China, published today in The BMJ.

26 Jan 2023

Mpox has been silently circulating in non-mpox-endemic nations for 20 years, according to new study

Researchers described the evolution of the mpox virus (MPXV) before the 2022 outbreak.

19 Jan 2023

How does the brain change with age?

Researchers discussed cellular hallmarks of brain aging and therapeutic interventions to rejuvenate cognitive brain functions.

19 Jan 2023

New research draws attention to the effects of deep meditation on gut health

Researchers investigated the effects of long-term traditional Tibetan Buddhist meditation on the gut microbiome's structural characteristics. Additionally, they screened microbes in the gut microbiota for insights into their biochemical indices and functionality.

19 Jan 2023

Long-term deep meditation may help to regulate the gut microbiome for better health

Regular deep meditation, practiced for several years, may help to regulate the gut microbiome and potentially lower the risks of physical and mental ill health, finds a small comparative study published in the open access journal General Psychiatry.

17 Jan 2023

Walking pace and handgrip strength can indicate dementia risk

The current study, published in the journal Alzheimer's Research & Therapy, drew data on almost 496,000 participants from the UK Biobank Study. None had symptoms or a diagnosis of dementia at the start of the study.

15 Jan 2023

Genomic analysis of mpox virus genomes reveal multiple lineages with human-to-human transmissibility

Researchers from Nigeria and the United Kingdom (U.K.) analyzed mpox virus genomes and found that divergent lineages of the mpox virus exhibiting human-to-human transmission existed in the Nigerian population before the 2022 spread of the virus outside of the endemic regions.

10 Jan 2023

Study supports association of the ε4 alleles and polygenic profiles with Alzheimer’s disease biomarkers

A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 24, entitled, "Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease biomarkers."

3 Jan 2023

Apolipoprotein News and Research

Early life adversity linked to accelerated neurobiological aging, raising vulnerability to depression and Alzheimer's

New review examines link between HDLC and different types of cancer

Fiber intake associated with lower risk of cognitive decline in old people with ApoE ε4 genotype

Reversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

Keto-like diet may be associated with elevated risk of cardiovascular events

Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Research investigates roles of neurotrophic factors on cognition in Alzheimer's patients carrying APOE ε4

Apolipoprotein E4 promotes the development of Alzheimer’s disease

Study reports that depleting gut bacteria in mice with genetic risk for AD reduces neuropathology in a sex-dependent manner

Can carbohydrate be reduced too low for weight loss, and glycemic control?

Study demonstrates intrahost MPXV variation within a single lesion

Study of older adults in China finds link between a healthy lifestyle and slower memory decline

Mpox has been silently circulating in non-mpox-endemic nations for 20 years, according to new study

How does the brain change with age?

New research draws attention to the effects of deep meditation on gut health

Long-term deep meditation may help to regulate the gut microbiome for better health

Walking pace and handgrip strength can indicate dementia risk

Genomic analysis of mpox virus genomes reveal multiple lineages with human-to-human transmissibility

Study supports association of the ε4 alleles and polygenic profiles with Alzheimer’s disease biomarkers

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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