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Combination treatment for advanced endometrial cancer significantly reduces disease growth

In a study published in the March 27, 2023, online edition of the New England Journal of Medicine, researchers at the University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health found the combination of immunotherapy (pembrolizumab) and chemotherapy in patients with advanced or recurrent/advanced endometrial cancer resulted in a significant reduction in disease growth when compared with chemotherapy alone.

27 Mar 2023

Updated expert consensus statement on transcatheter left atrial appendage closure released

Today, the Society for Cardiovascular Angiography & Interventions and the Heart Rhythm Society released an updated expert consensus statement on transcatheter left atrial appendage closure (LAAC).

27 Mar 2023

Researchers discover a new switching point that regulates hemostasis and thrombosis

The glycoprotein V of the blood platelets is an important switch point for hemostasis and thrombus formation. This new finding could have great clinical potential.

24 Mar 2023

UTSW expert advises screening by 55 for people with family history of age-related macular degeneration

Patients with a family history of age-related macular degeneration (AMD), the leading cause of permanent vision loss in those older than 60, should visit an ophthalmologist by age 55 to be screened for signs of the disease, advises an expert at UT Southwestern Medical Center.

21 Mar 2023

Pregnant women involved in road traffic collisions have higher risks of birth complications

Pregnant women involved in road traffic collisions—even those with minor injuries—are at heightened risk of potentially serious birth complications, including dislodgement of the placenta (placental abruption), very heavy bleeding, and the need for a cesarean section, finds a Taiwanese study published online in the journal Injury Prevention.

21 Mar 2023

Study finds higher levels of oral disease among patients with adverse mental health conditions

A study examining the mental health-oral health association cross-sectionally and longitudinally was presented at the 52nd Annual Meeting & Exhibition of the AADOCR, held in conjunction with the 47th Annual Meeting of the CADR.

20 Mar 2023

Researchers find new way to remove waste after brain hemorrhage

University of Helsinki and Taiwanese researchers have found a new way to remove waste from the brain after hemorrhage.

17 Mar 2023

Venous thromboembolism is rare among non-hospitalized COVID-19 patients

In a recent study published in the journal JAMA Network Open, researchers in the United States assessed the risk and aimed to identify the independent predictors of venous thromboembolism events in outpatients who had less severe manifestations of coronavirus disease 2019 (COVID-19).

16 Mar 2023

New biomimetic model helps study wound healing in burn and laceration wounds

Burn wounds are notoriously prone to bacterial infection and typically lead to a larger amount of scar tissue than laceration wounds.

15 Mar 2023

Black patients dress up and modify speech to reduce bias, California survey shows

A young mother in California's Antelope Valley bathes her children and dresses them in neat clothes, making sure they look their very best — at medical appointments. "I brush their teeth before they see the dentist. Just little things like that to protect myself from being treated unfairly," she told researchers.

10 Mar 2023

Examining the effect of hormone replacement therapy on postmenopausal heart disease and cognitive decline

Many are aware of the short-term symptoms often associated with menopause, such as hot flashes, which are attributed to changes in reproductive hormones.

9 Mar 2023

Novel molecular mechanism responsible for common form of acquired hydrocephalus discovered

Mass General researchers have discovered a novel molecular mechanism responsible for the most common forms of acquired hydrocephalus, potentially opening the door to the first-ever nonsurgical treatment for a life-threatening disease that affects about a million Americans.

8 Mar 2023

Detection and targeting of splicing deregulation reveal a potential strategy for pAML therapy

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

Girls in Texas could get birth control at federal clinics, until a Christian father objected

On the vast Texas Panhandle, raked by wind and relentless sun, women might drive for hours to reach Haven Health, a clinic in Amarillo.

8 Mar 2023

First-in-woman study of a non-hormonal vaginal film showed safety, potential contraceptive efficacy, and supports future development

Researchers developed a novel contraceptive 'ZB-06' a vaginal film containing a human contraceptive antibody called HC4-N that agglutinates sperm.

7 Mar 2023

High-dose anticoagulation can reduce deaths, intubations in hospitalized COVID-19 patients

High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation.

6 Mar 2023

Non-critically ill hospitalized Covid-19 patients could substantially benefit from a higher dose of blood-thinners

Giving noncritically ill patients hospitalized for COVID-19 a higher dose of blood-thinning medication than usual did not significantly reduce the combined risk of death from any cause, need for treatment in an intensive-care unit, a confirmed blood clot or a stroke at 30 days, according to the results of the FREEDOM-COVID trial presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Patients with pulmonary arterial hypertension (PAH), a severe, progressive condition that affects the heart and lungs, who were treated with the novel first-in-class medication sotatercept on top of existing therapy experienced significant improvements in walking distance via a six-minute walking test—the study's primary endpoint and a validated surrogate for functional improvement and reduced symptom burden.

6 Mar 2023

Minimally invasive mitral valve repair is as safe and effective as conventional surgery, trial shows

In the largest randomized trial conducted to compare minimally invasive and conventional cardiac surgical techniques for repairing a poorly functioning mitral valve, improvements in physical activity, as well as surgical outcomes and quality of life, were similar in both groups of patients at 12 weeks post-surgery.

5 Mar 2023

Existing CT scans estimate hardened fatty plaque deposits in the heart's largest blood vessels

Instead of special heart scans, physicians can use images of the chest captured months earlier, and for other reasons, to estimate patients' risk of heart attack or death during several kinds of major surgeries, a new study shows.

2 Mar 2023

Bleeding News and Research

Combination treatment for advanced endometrial cancer significantly reduces disease growth

Updated expert consensus statement on transcatheter left atrial appendage closure released

Researchers discover a new switching point that regulates hemostasis and thrombosis

UTSW expert advises screening by 55 for people with family history of age-related macular degeneration

Pregnant women involved in road traffic collisions have higher risks of birth complications

Study finds higher levels of oral disease among patients with adverse mental health conditions

Researchers find new way to remove waste after brain hemorrhage

Venous thromboembolism is rare among non-hospitalized COVID-19 patients

New biomimetic model helps study wound healing in burn and laceration wounds

Black patients dress up and modify speech to reduce bias, California survey shows

Examining the effect of hormone replacement therapy on postmenopausal heart disease and cognitive decline

Novel molecular mechanism responsible for common form of acquired hydrocephalus discovered

Detection and targeting of splicing deregulation reveal a potential strategy for pAML therapy

Girls in Texas could get birth control at federal clinics, until a Christian father objected

First-in-woman study of a non-hormonal vaginal film showed safety, potential contraceptive efficacy, and supports future development

High-dose anticoagulation can reduce deaths, intubations in hospitalized COVID-19 patients

Non-critically ill hospitalized Covid-19 patients could substantially benefit from a higher dose of blood-thinners

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Minimally invasive mitral valve repair is as safe and effective as conventional surgery, trial shows

Existing CT scans estimate hardened fatty plaque deposits in the heart's largest blood vessels

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Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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