Daughter Cell News and Research

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Discovery of key acute myeloid leukemia gene

A gene called N-Myc leads a double life in certain white blood cells, helping to trigger a cancer called acute myeloid leukemia (AML) under some conditions while triggering apoptosis, or cell suicide, under other conditions, according to results of a mouse study done by investigators at St. Jude Children's Research Hospital.

27 Nov 2007

Morphotek issued new U.S patent for method to enhance the affinity of monoclonal antibodies

Morphotek, Inc., a subsidiary of Eisai Co., Ltd. has announced the issuance of United States Patent No. 7,235,643 B2 (the "643" patent).

19 Nov 2007

Potent inhibitor of Kinesin CENP-E demonstrates tumor cell inhibition

A first-in-class, targeted investigational therapy specifically designed to inhibit a single protein that functions only during cell division shows potent activity in a broad range of cancer cell lines, say researchers from GlaxoSmithKline.

24 Oct 2007

Experimental cancer pharmaceuticals under trial

A potent and selective inhibitor of the mitotic kinesin CENP-E (GSK923295A) demonstrates a novel mechanism of inhibiting tumor cell proliferation and shows activity against a broad panel of human tumor cell lines in vitro: Abstract A 111.

24 Oct 2007

Transgenics sped up

A new method of constructing artificial plant chromosomes from small rings of naturally occurring plant DNA can be used to transport multiple genes at once into embryonic plants where they are expressed, duplicated as plant cells divide, and passed on to the next generation -- a long-term goal for those interested in improving agricultural productivity.

19 Oct 2007

A fresh perspective to the study of cell activity

In process that is shrouded in mystery, rod-shaped bacteria reproduce by splitting themselves in two. By applying advanced mathematics to laboratory data, a team led by Johns Hopkins researchers has solved a small but important part of this reproductive puzzle.

12 Oct 2007

Better understanding of environmental influences on the aging process of stem cells

A stem cells' immediate neighborhood, a specialized environment also known as the stem cell niche, provides crucial support needed for stem cell maintenance.

10 Oct 2007

Gene may hold key to future cancer hope

Scientists may have discovered a new way of killing tumours in what they hope could one day lead to alternative forms of cancer treatments.

From The University of Manchester 9 Oct 2007

The cell size problem

For more than 100 years, scientists have tried to figure out the cell size problem: How does a cell know when it is big enough to divide?

25 Sep 2007

Researchers pinpoint when a cell is ready to reproduce

For more than 100 years, scientists have tried to figure out the cell size problem: How does a cell know when it is big enough to divide, In research conducted in budding yeast ( Saccharomyces cerevisiae ), scientists at Rockefeller University have now identified the cellular event that marks the moment when a cell knows it is big enough to commit to cell division and spawn genetic replicas of itself.

24 Sep 2007

Researchers dispute immortal strand hypothesis

How do adult stem cells protect themselves from accumulating genetic mutations that can lead to cancer?

30 Aug 2007

New insights into cell division process

Which genes are passed on from mother to child is decided very early on during the maturation of the egg cell in the ovary.

12 Aug 2007

Promising new line in anti-cancer therapy

A promising new line in anti-cancer therapy by blocking the molecular motors involved in copying genetic information during cell division is being pursued by young Dutch researcher Dr. Nynke Dekker in one of this year's EURYI award winning projects sponsored by the European Science Foundation (ESF) and the European Heads of Research Councils (EuroHORCS).

11 Aug 2007

Electricity - a new weapon for stalling the progression of cancer

Low-intensity electric fields can disrupt the division of cancer cells and slow the growth of brain tumors, suggest laboratory experiments and a small human trial, raising hopes that electric fields will become a new weapon for stalling the progression of cancer.

3 Aug 2007

Discovery of pathway that controls cell size and division

Organisms precisely regulate cell size to ensure that daughter cells have sufficient cellular material to thrive or to create specific cell types: a tiny sperm versus a gargantuan egg for example.

1 Aug 2007

Chromosomes responsible for a critical enzyme's activation during cell division

In a dividing cell, chromosomes interact with cellular scaffolding - called spindle microtubules - in order to move themselves to opposite ends of the cell, ensuring that both daughter cells receive an exact copy of their parent cell's genetic material.

1 Aug 2007