Triple Negative Breast Cancer News and Research

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New method for scDNA sequencing provides insights into breast cancer evolution

vercoming previous technical challenges with single-cell DNA (scDNA) sequencing, a group led by researchers at The University of Texas MD Anderson Cancer Center has developed a novel method for scDNA sequencing at single-molecule resolution.

24 Mar 2021

YAP inhibitors could facilitate targeted treatment of basal-like breast cancer

Targeted treatment of basal-like breast cancer could be facilitated by YAP inhibitors in the future. As reported by an MDC team headed by Walter Birchmeier in the scientific journal Cancer Research, this type of cancer requires the support of the YAP protein to stimulate the growth of cancer stem cells.

22 Mar 2021

Henry Ford Cancer Institute launches new initiative to improve minority participation in clinical trials

Henry Ford Cancer Institute is launching the Participatory Action for Access to Clinical Trials (PAACT) project to dramatically improve the representation of the African American community and other minorities in cancer clinical trials.

11 Mar 2021

Compound isolated from Moroccan fungus shows promise to fight triple negative breast cancer

A compound isolated from a fungus growing on the roots of a flowering plant in Morocco shows promise as a powerful opponent of aggressive triple negative breast cancer, scientists say.

4 Mar 2021

Salk Institute uses $1 million gift to support world class cancer researcher

The Salk Institute received a matching $1 million gift from the BioMed Realty Management Team, which was used to fund the recruitment of award-winning cancer researcher Christina Towers and to support her research and that of the Salk Cancer Center.

24 Feb 2021

Study: Abundance of iron can drive cancer cell death in neuroblastoma

Neuroblastoma is a cancer that develops in nerve tissue, most commonly in the glands around the kidneys. The gene MYCN is overexpressed in 20-25% of neuroblastoma, and MYCN-amplified neuroblastoma contributes to a considerable percentage of pediatric cancer-related deaths.

24 Feb 2021

Cancer cell vulnerability could be a potential target for interrupting tumor growth

Unraveling the unique characteristics of cancer cells and finding less-harmful ways to stop their growth have long been a focus for cancer researchers worldwide.

22 Feb 2021

New drug shows promise in treating pancreatic and breast cancers

ProAgio, a drug developed by Georgia State University biology professor Zhi-Ren Liu and his team, is effective at treating pancreatic cancer and prolonging survival in mice, according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatology.

9 Feb 2021

Compound isolated from Ophiura sarsii can be used as an affordable drug for photodynamic therapy

An unusual biologically active porphyrin compound was isolated from seabed dweller Ophiura sarsii. The substance might be used as an affordable light-sensitive drug for innovative photodynamic therapy and for targeted treatment of triple-negative breast cancer and some other cancers.

8 Feb 2021

Tiny molecular motions are of key significance in modern anti-cancer drugs

Modern immunotherapeutic anti-cancer drugs support a natural mechanism of the immune system to inhibit the growth of cancer cells.

3 Feb 2021

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Using the developing eye of the fruit fly as a test platform, researchers found that RPS-12 protein overproduction appears to trigger triple-negative breast cancer and possibly some other malignancies.

29 Jan 2021

IU researchers identify how breast cancer cells evade immune attacks

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified how breast cancer cells hide from immune cells to stay alive. The discovery could lead to better immunotherapy treatment for patients.

27 Jan 2021

New computational technique accurately differentiates between data from tumor cells and normal cells

In an effort to address a major challenge when analyzing large single-cell RNA-sequencing datasets, researchers from The University of Texas MD Anderson Cancer Center have developed a new computational technique to accurately differentiate between data from cancer cells and the variety of normal cells found within tumor samples.

18 Jan 2021

Targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers

Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response.

15 Jan 2021

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether. This is called chromosomal instability, and scientists at Memorial Sloan Kettering have learned that it is associated with cancer's aggressiveness.

28 Dec 2020

Study finds how macrophages may contribute to a therapeutic weak spot in breast cancer

Breast cancer, the second most common cancer in the United States, can result from a number of cellular misregulations, such as deficiencies in the DNA-repairing breast cancer gene, BRCA.

18 Dec 2020

New tool aids in the discovery of RNA medicines for undruggable diseases

Imagine trying to throw a bullseye when the dartboard lies buried within a crumpled box. That's the challenge faced by scientists working to make new medicines for some "undruggable" diseases, including a type of metastatic breast cancer.

15 Dec 2020

Combination therapy places no greater burden on early-stage breast cancer patients

Adding an immune checkpoint inhibitor to the standard chemotherapy regimen for patients with early-stage breast cancer places no greater burden on patients' ability to perform day-to-day activities than chemotherapy alone, new research by Dana-Farber/Brigham and Women's Cancer Center investigators shows.

10 Dec 2020

Study demonstrates safety of novel immuno-oncology therapy in patients with advanced solid tumors

A novel therapy designed to help stimulate the body's immune system response against cancer appears to be safe to use as alone or in combination with immune checkpoint inhibitors.

1 Dec 2020

UVA researchers discover gene responsible for the metastasis of triple-negative breast cancer

University of Virginia Cancer Center researchers have identified a gene responsible for the spread of triple-negative breast cancer to other parts of the body - a process called metastasis - and developed a potential way to stop it.

20 Nov 2020