Mouse Model News and Research

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New study focuses on promise of gene therapy for Amish nemaline myopathy

A new comprehensive natural history study about Amish nemaline myopathy in the Old Order Amish population focuses on the promise of gene therapy for this lethal disorder.

14 Aug 2018

Autoimmune response contributes to vision loss in glaucoma patients

A research team from Massachusetts Eye and Ear and MIT has shown that immune cells in the eye that developed in response to early exposure to bacteria are a key contributor to progressive vision loss from glaucoma, the second leading cause of irreversible blindness in the world.

10 Aug 2018

Defects in RNA modification can cause altered smooth muscle contraction

Genetic information is stored in DNA and is passed on in a very stable manner from one cell to the next or from one generation to the next.

9 Aug 2018

Scientists identify drug that could reverse pulmonary arterial hypertension

Scientists at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago took a major step toward developing a new treatment for pulmonary arterial hypertension, a severe lung disease with a five-year survival rate of 50 percent.

9 Aug 2018

Researchers identify role of infection-fighting cells in inflamed and damaged tissue

Hookworms infect nearly 430 million people in the world, mostly in countries where sanitation is poor, and people often walk barefoot.

7 Aug 2018

Doxorubicin drug causes heart toxicity by disrupting the immune system

Doxorubicin is a chemotherapy drug widely used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure.

7 Aug 2018

Researchers identify new regulator in breast cancer cells

Triple-negative breast cancer is a particularly aggressive form of breast cancer. Here, important receptors are missing, which often serve as targets for treatments.

6 Aug 2018

Research uncovers new approach for expanding stem cells from umbilical cord blood

Researchers from the Stowers Institute for Medical Research and collaborators have identified a way to expand blood-forming, adult stem cells from human umbilical cord blood.

3 Aug 2018

Study provides new insights into how asthma develops and progresses

Of the more than 24 million people in the U.S. who have asthma, 10 percent have severe asthma - a form of the disease that does not respond to treatment.

3 Aug 2018

Alcohol increases mortality in young mice infected with tuberculosis-causing bacterium

Alcohol increases the mortality of young but not old mice infected with the tuberculosis-causing bacterium Mycobacterium tuberculosis, and this effect is mediated by the production of a protein called interferon-alpha.

3 Aug 2018

Tumor suppressor gene PTEN may be potential Achilles heel for breast cancer cells

In an article published July 17, 2018 by Nature Communications, a highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report that normal breast cells can prevent successful radiation treatment of breast cancer due to dysregulation between tumor suppressors and oncogenes.

2 Aug 2018

Breakthrough in stem cell research could lead to cure for cystic fibrosis

Researchers have successfully proved that gene therapy can be used to convert adult stem cells into functioning lung cells for the treatment of cystic fibrosis

2 Aug 2018

Researchers find possible active substance that may cure hepatitis E

An international team of researchers has now found a possible active substance against the virus in the naturally occurring substance silvestrol.

1 Aug 2018

Glaucoma Research Foundation-funded research makes breakthrough in treatment of glaucoma

Glaucoma Research Foundation, a national non-profit organization dedicated to finding a cure for glaucoma, today announced a team of neuroscience researchers, led by Adriana Di Polo, PhD, at University of Montreal, have made a major breakthrough in the treatment of glaucoma.

31 Jul 2018

Gene linked to hair loss could be exploited to improve cancer immunotherapy

A gene that's associated with an autoimmune form of hair loss could be exploited to improve cancer immunotherapy, suggests a new mouse study by Columbia University Irving Medical Center (CUIMC) researchers.

31 Jul 2018

New improved mouse model could revolutionize bone metastasis research

Researchers at Tokyo Institute of Technology propose an improved mouse model that could revolutionize bone metastasis research. Their method, which involves injecting cancer cells via the so-called caudal artery in the mouse tail, overcomes many limitations of traditional mouse models.

30 Jul 2018