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Heroin could could help patients with narcolepsy

A new study has found that users of heroin have high levels of a brain chemical called hypocretin. This hypocretin leads to “wakefulness” among the users and understanding this could help patients with narcolepsy.

29 Jun 2018

Scientists discover protein crucial for activating inflammation

Researchers from the University of Illinois at Chicago have identified a protein that is crucial for activating inflammation - both the good kind of inflammation that leads to healing wounds and fighting infection, as well as excessive inflammation where the immune system can damage tissues and organs.

27 Jun 2018

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

In preclinical experiments, Laurie Harrington, Ph.D., and colleagues at the University of Alabama at Birmingham have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease.

27 Jun 2018

New nuclear medicine approach shows potential for precision treatment of solid tumors

A novel nuclear medicine approach is showing great promise for precision treatment of solid tumors in many types of cancer--including lung, breast, pancreas and ovarian in adults and glioma, neuroblastoma and sarcoma in children.

26 Jun 2018

Study reveals new way to inhibit capillary leakage in sepsis

Leakage from the blood capillaries is a key mechanism leading to septic shock and multiorgan failure, which affect millions of patients annually worldwide. However, there is no effective way to inhibit the vessel leakiness. A new study by scientists at the University of Helsinki and Wihuri Research Institute demonstrates that vascular leakage can be inhibited by targeting vascular integrins.

25 Jun 2018

Study explains methods for matrix decellularization to promote bone regeneration

To help prevent possible complications such as nonunion at large fracture sites, researchers have developed a cartilage matrix that mimics the early stages of repair and provides the essential structural and biological properties needed by bone-forming cells to divide and grow.

25 Jun 2018

New therapeutic approach may delay neurodegeneration in rare genetic disease

A new therapeutic approach may one day delay neurodegeneration typical of a disease called mucopolysaccharidoses IIIB. Neurodegeneration in this condition results from the abnormal accumulation of essential cellular molecules called mucopolysaccharides.

21 Jun 2018

Researchers employ nucleotide-based gene silencing to mitigate common ataxia

In what researchers are calling a game changer for future ataxia treatments, a new study showed the ability to turn down the disease progression of the most common dominantly inherited ataxia.

20 Jun 2018

Study opens new window into cellular events that occur in the brain during absence seizures

At first, the teacher described her six-year-old student as absentminded, a daydreamer. The boy was having difficulty paying attention in class. As the teacher watched the boy closely, she realized that he was not daydreaming. He often blanked out for a few seconds and wouldn't respond when she called his name. On occasion, he would blink a lot and his eyes would roll up.

20 Jun 2018

Neuroscientists map feeling of cool touch to the brain’s insula in mouse model

Carnegie Mellon University neuroscientists have mapped the feeling of cool touch to the brain's insula in a mouse model.

18 Jun 2018

Drug used to treat myelofibrosis can awaken ‘dormant’ lymphomas in the bone marrow

Most patients with myelofibrosis, a rare chronic disorder of the haematopoietic cells of the bone marrow, benefit from drugs from the JAK2 inhibitor class: symptoms are relieved, survival extended and general quality-of-life enhanced.

18 Jun 2018

Zika Virus: What Does the Future Hold?

Following the Zika virus epidemic that swept across Brazil between 2015-2016, Dr. Julia Clarke and her team begun working to establish the long-term effects of Zika, and recently discovered that TNF-a inhibitors can be used to prevent microencephaly.

18 Jun 2018

Researchers identify gene enhancer that affects sex determination

Researchers have identified a gene enhancer that is critical for male sex development and shown that deleting it results in male-to-female sex reversal in mice.

15 Jun 2018

Older melanoma patients fare better on immune checkpoint blockade therapy

Patient age correlates with response to immunotherapy in melanoma and depleting regulatory T cells in young patients may have a therapeutic potential to enhance response in younger patients, according to research from The Wistar Institute. Study results were published online in Clinical Cancer Research.

13 Jun 2018

Researchers identify new form of depression

In a new study, researchers from Hiroshima University have identified a new form of depression that could be used to inform a new generation of treatments.

11 Jun 2018

Research drug may one day be novel treatment for systemic inflammatory response syndrome

When trauma spills the contents of our cell powerhouses, it can evoke a potentially deadly immune response much like a severe bacterial infection.

11 Jun 2018

Researchers isolate bacteria that pose triple threat from a patient in the U.S.

Researchers from the Emory Antibiotic Resistance Center describe the first strain of carbapenem-resistant, hypermucoviscous Klebsiella pneumoniae exhibiting colistin heteroresistance and enhanced virulence isolated from a patient in the United States.

11 Jun 2018

Some tumors use two levels of protection against immune system, shows study

In research published today, Babraham Institute researchers have shown that some tumors use not one but two levels of protection against the immune system.

8 Jun 2018

Study demonstrates that HIV infection in the brain can be established, maintained by T cells

A new study by University of North Carolina School of Medicine researchers has found that T cells, a type of white blood cell and an essential part of the immune system, are sufficient by themselves to establish and maintain an HIV infection in the brain.

6 Jun 2018

New way of delivering gene therapy shows promise in treating brain conditions

Researchers from the School of Immunology & Microbial Sciences have engineered a novel way of delivering gene therapy that they hope will mean scientists and doctors can target areas of the brain that were previously difficult to reach.

5 Jun 2018

Mouse Model News and Research

Heroin could could help patients with narcolepsy

Scientists discover protein crucial for activating inflammation

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

New nuclear medicine approach shows potential for precision treatment of solid tumors

Study reveals new way to inhibit capillary leakage in sepsis

Study explains methods for matrix decellularization to promote bone regeneration

New therapeutic approach may delay neurodegeneration in rare genetic disease

Researchers employ nucleotide-based gene silencing to mitigate common ataxia

Study opens new window into cellular events that occur in the brain during absence seizures

Neuroscientists map feeling of cool touch to the brain’s insula in mouse model

Drug used to treat myelofibrosis can awaken ‘dormant’ lymphomas in the bone marrow

Zika Virus: What Does the Future Hold?

Researchers identify gene enhancer that affects sex determination

Older melanoma patients fare better on immune checkpoint blockade therapy

Researchers identify new form of depression

Research drug may one day be novel treatment for systemic inflammatory response syndrome

Researchers isolate bacteria that pose triple threat from a patient in the U.S.

Some tumors use two levels of protection against immune system, shows study

Study demonstrates that HIV infection in the brain can be established, maintained by T cells

New way of delivering gene therapy shows promise in treating brain conditions

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