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Scientists map autism genetic pathway that regulates brain development

Scientists at the University of California, San Diego School of Medicine have found that mutations that cause autism in children are connected to a pathway that regulates brain development. The research, led by Lilia Iakoucheva, PhD, assistant professor in the Department of Psychiatry, is published in the February 18 issue of Neuron.

19 Feb 2015

Epigenome may hold promise for conquering diseases

The human genome project captured the public imagination when its first draft was published 14 years ago this week in the international science journal Nature, but the epigenome may hold the real promise for conquering disease.

19 Feb 2015

UCSD researchers make new attempt to develop malaria vaccine candidate

Researchers at University of California, San Diego School of Medicine used algae as a mini-factory to produce a malaria parasite protein. The algae-produced protein, paired with an immune-boosting cocktail suitable for use in humans, generated antibodies in mice that nearly eliminated mosquito infection by the malaria parasite.

19 Feb 2015

Researchers develop artificial adrenal system in animal model

If the function of the adrenal gland is disturbed it does not produce enough stress-adjusting messengers. The results are serious and cause life-threatening diseases. Under the direction of Prof. Dr. Stefan R. Bornstein of the university hospital Carl Gustav Carus researchers developed an artificial adrenal system together with the medicine Nobel Prize Laureate Prof. Dr. Andrew Schally in an animal model.

19 Feb 2015

Gut microbial metabolite of linoleic acid has suppressive effect on intestinal inflammation

Inflammatory bowel diseases (IBDs), including Crohn disease and ulcerative colitis, are hard to completely cure. Globally, IBDs affect more than 4 million people, today. However, Professor Soichi Tanabe (Graduate School of Biosphere Science, Hiroshima University) and his collaborators have demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect on intestinal inflammation.

19 Feb 2015

Lupus Research Institute announces this year's Novel Research Grants

As the Lupus Research Institute celebrates its 15th anniversary, the engine of innovation moves forward at accelerated speed with the announcement of this year's Novel Research Grants bringing new talent from a wide diversity of specialties. Each project lives up to the strictest definition of novel – wholly original, never-been-done-before.

19 Feb 2015

EC grants orphan drug designation to aTyr Pharma's Resolaris for treatment of FSHD

aTyr Pharma, Inc., a biotherapeutics company engaged in the discovery and development of Physiocrine-based therapeutics to address rare diseases, announced today the European Commission (EC) has granted orphan drug designation to Resolaris for the treatment of facioscapulohumeral muscular dystrophy (FSHD).

19 Feb 2015

Scientists identify potential target to combat leishmaniasis

Research led by St. Jude Children's Research Hospital scientists has identified a potential target in the quest to develop a more effective treatment for leishmaniasis, a parasitic tropical disease that kills thousands and sickens more than 1 million people worldwide each year.

19 Feb 2015

TSRI scientists develop new drug candidate against HIV

In a remarkable new advance against the virus that causes AIDS, scientists from the Jupiter, Florida campus of The Scripps Research Institute have announced the creation of a novel drug candidate that is so potent and universally effective, it might work as part of an unconventional vaccine.

18 Feb 2015

First comprehensive maps and analyses of human epigenomes revealed

Two dozen scientific papers published online simultaneously on Feb. 18, 2015 present the first comprehensive maps and analyses of the epigenomes of a wide array of human cell and tissue types. Epigenomes are patterns of chemical annotations to the genome that determine whether, how, and when genes are activated.

18 Feb 2015

UT Southwestern scientists identify new biomarker that could optimize chemotherapy response

UT Southwestern Medical Center scientists have identified a new biomarker that could help identify patients who are more likely to respond to certain chemotherapies.

18 Feb 2015

Findings may help doctors recommend appropriate treatments, improve patient outcomes

Like a car's front and back bumpers, your cell's chromosomes are capped by "telomeres" that protect this genetic material against deterioration. Still, after enough replications, a chromosome's telomeres break down and once they reach a certain point of degradation, the cell dies. This is one reason that cells are mortal: telomeres only last so long. That is, unless the enzyme telomerase builds new material onto the worn telomeres to reinforce these chromosomal "bumpers". Telomere repair can be a good thing, but in some cases it's not: overactive telomerase can lengthen telomeres until a cell becomes immortal…leading to cancer.

18 Feb 2015

Facts about precision medicine

President Barack Obama is requesting an increase of $215 million in the 2016 federal budget to launch the Precision Medicine Initiative. This boost in funding for research will give genetic causes of cancer a national focus specifically around precision or "personalized" treatments for cancer in the future.

18 Feb 2015

Caris Life Sciences announces record-setting revenue for 2014

Caris Life Sciences, a leading biosciences company focused on fulfilling the promise of precision medicine, today announced select year-end financial and operational results for 2014, which include record-setting revenue and continued case volume growth for its panomic, comprehensive tumor profiling service, Caris Molecular Intelligence.

18 Feb 2015

Scientists identify role of tau-associated MAPT gene in development of Alzheimer's disease

An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, has identified the microtubule-associated protein tau (MAPT) gene as increasing the risk for developing Alzheimer's disease (AD).

18 Feb 2015

New compound appears to play role in development of opioid tolerance

While opioids are a widely used treatment for pain, patients who take them on a regular basis can become tolerant, requiring a higher dose for continued pain relief. In a study published in Anesthesiology, the official medical journal of the American Society of Anesthesiologists, researchers identified a compound that appears to play a role in the development of opioid tolerance.

18 Feb 2015

Corticosteroids decrease treatment failure among patients with community-acquired pneumonia

Among patients with severe community-acquired pneumonia and high initial inflammatory response, the use of the corticosteroid methylprednisolone decreased treatment failure, compared with placebo, according to a study in the February 17 issue of JAMA.

18 Feb 2015

Researchers identify molecule that can block progression of Alzheimer's disease

A molecule that can block the progress of Alzheimer's disease at a crucial stage in its development has been identified by researchers in a new study, raising the prospect that more such molecules may now be found.

18 Feb 2015

Trinity scientists reveal new marvel molecule that can block key process in inflammatory diseases

Scientists at Trinity College Dublin have uncovered a marvel molecule that blocks a key driver of inflammatory diseases. The finding could meet a major unmet clinical need by inspiring new non-invasive treatments for arthritis, multiple sclerosis and Muckle-Wells syndrome, among a myriad of other inflammatory diseases.

18 Feb 2015

UT Arlington chemist receives NIH's Academic Research Enhancement Award for protein research

A University of Texas at Arlington bio-analytical chemist exploring proteins, their structures and functions by using cutting-edge analytical instrumentation called mass spectrometry has received an Academic Research Enhancement Award from the National Institutes of Health.

18 Feb 2015

Protein C News and Research

Scientists map autism genetic pathway that regulates brain development

Epigenome may hold promise for conquering diseases

UCSD researchers make new attempt to develop malaria vaccine candidate

Researchers develop artificial adrenal system in animal model

Gut microbial metabolite of linoleic acid has suppressive effect on intestinal inflammation

Lupus Research Institute announces this year's Novel Research Grants

EC grants orphan drug designation to aTyr Pharma's Resolaris for treatment of FSHD

Scientists identify potential target to combat leishmaniasis

TSRI scientists develop new drug candidate against HIV

First comprehensive maps and analyses of human epigenomes revealed

UT Southwestern scientists identify new biomarker that could optimize chemotherapy response

Findings may help doctors recommend appropriate treatments, improve patient outcomes

Facts about precision medicine

Caris Life Sciences announces record-setting revenue for 2014

Scientists identify role of tau-associated MAPT gene in development of Alzheimer's disease

New compound appears to play role in development of opioid tolerance

Corticosteroids decrease treatment failure among patients with community-acquired pneumonia

Researchers identify molecule that can block progression of Alzheimer's disease

Trinity scientists reveal new marvel molecule that can block key process in inflammatory diseases

UT Arlington chemist receives NIH's Academic Research Enhancement Award for protein research

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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