Mouse Model News and Research

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Study finds link between inflammatory signals in heart muscle cells and atrial fibrillation

Interfering with inflammatory signals produced by heart muscle cells might someday provide novel therapeutic strategies for atrial fibrillation, according to an international team of researchers who have published their findings in the journal Circulation.

5 Jun 2018

Novel PET imaging shows promise for noninvasively detecting inflammation in people with IBD

A novel positron emission tomography imaging method shows promise for noninvasively pinpointing sites of inflammation in people with inflammatory bowel disease, which includes ulcerative colitis and Crohn's disease.

4 Jun 2018

Scientists reveal role of lung scavenger cells in liver cancer spread to the lungs

Hepatocellular carcinoma is the most common form of liver cancer, and the third biggest cause of death from cancer worldwide.

4 Jun 2018

Scientists report involvement of estrogen hormone receptor in autoimmune diseases

Women are more prone to the development of autoimmune diseases. The female hormone estrogen is likely to affect the immune system.

1 Jun 2018

Study shows blood stem cells compensate for immune cell deficiencies

Researchers have shown that if certain blood stem cells that produce immune cells are deficient, other blood stem cells compensate by overproducing the immune cells that are lacking.

30 May 2018

Researchers uncover the cause of rheumatoid arthritis

A team of researchers have identified the cellular network involved in initiating and maintaining chronic inflammation in rheumatoid arthritis.

30 May 2018

Study reveals new protective mechanism for tumor cells in breast cancer

Greater knowledge of the mechanisms that contribute to the survival of tumor cells is key to vanquishing them.

25 May 2018

International researchers succeed in stopping growth of mesothelioma in model animals

An international team led by researchers from the Technion-Israel Institute of Technology and NYU Langone Health have succeeded in stopping the growth of mesothelioma in model animals by inhibiting the heparanase enzyme.

24 May 2018

CU research sheds light on liver disease caused by intravenous nutrition

Research by physician-scientists at the University of Colorado Anschutz Medical Campus offers hope for improved quality of life for people who rely on intravenous nutrition due to intestinal damage.

24 May 2018

Mapping the Genes Responsible for Pluripotency

Dr. Atilgan Yilmaz and his team have developed a method by which they can produce haploid human embryonic stem cells from oocytes. They combined this technique with CRISPR-Cas9 to generate an atlas of the genome, containing the functions of over 18,000 genes.

23 May 2018

ToolGen's CRISPR/Cas9 gene editing platform improves T-cell anti-tumor activity in mouse model

ToolGen, Inc., a biotechnology company specializing in genome editing, today announced data demonstrating that blocking a molecular pathway that down-regulates T-cell activity with the Company’s CRISPR/Cas9 gene editing platform results in increased T-cell receptor signaling, in vitro, and in improved anti-tumor activity when tested against in a mouse glioblastoma tumor model.

22 May 2018

Novel drug prevents memory impairment in mice exposed to simulated deep space radiation

Planning a trip to Mars? You'll want to remember your anti-radiation pills. NASA and private space companies like SpaceX plan to send humans to the red planet within the next 15 years--but among the major challenges facing future crewed space missions is how to protect astronauts from the dangerous cosmic radiation of deep space.

22 May 2018

Researchers create tool to determine patient's response to immunotherapy drugs

Understanding that not all bladder cancers are the same, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center have created a tool that may help them to uncover why only a fraction of patients respond to new immune-based treatments.

21 May 2018

Clinical trial begins enrollment to test safety of experimental MERS treatments

Enrollment has begun in an early-stage clinical trial testing the safety of two human monoclonal antibodies (mAbs) designed to treat people infected with Middle East respiratory syndrome coronavirus (MERS-CoV).

18 May 2018

Researchers report new signaling exchange that mediates normal mammary gland development

The human body develops most tissue types during fetal development, in a mother's uterus. Yet one only tissue develops after birth: the mammary gland.

18 May 2018

Researchers discover mutation that can protect against Alzheimer's disease in mice

Researchers at the RIKEN Center for Brain Science have discovered a mutation that can protect against Alzheimer's disease in mice. Published in the scientific journal Nature Communications, the study found that a specific mutation can reduce the characteristic accumulation of the amyloid-beta peptide that occurs.

16 May 2018

Researchers use body odor to diagnose malaria

An international team of researchers recently discovered that malaria could be diagnosed through changes in body odor.

15 May 2018

New study to explore link between diet, intestinal microbiota and cognitive decline

Are abnormal intestinal microorganisms a risk factor for developing cognitive impairment? Researchers at Rush University Medical Center are trying to answer that question with a new study that will explore how the intestinal microbiota – the bacteria in the intestine –influence the progression of cognitive decline and the development of Alzheimer's disease.

14 May 2018

Enhancing the effects of vitamin D to curb type 2 diabetes

More than 27 million people in the United States are living with type 2 diabetes, according to the Centers for Disease Control and Prevention. As the population ages and a growing percentage of people become overweight or obese, that number is expected to increase.

10 May 2018

Researchers manipulate bacterial species in the gut using diet

Scientists from Stanford University School of Medicine have shown that by manipulating diet in a mouse model, it is possible to favor the engraftment of a specific bacterial strain over others.