Genes News and Research

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FoxOs shown to be potential new targets for cancer drugs

In an elegant, multiple-gene knockout experiment, a team of Boston scientists has discovered that a trio of molecules, called FoxOs, are fundamentally critical in preventing some cancers, maintaining blood vessel stability, and in keeping blood-forming stem cells healthy.

29 Jan 2007

RNA used to turn on genes to alleviate disease

A new technique that employs RNA, a tiny chemical cousin of DNA, to turn on genes could lead to therapeutics for conditions in which nudging a gene awake would help alleviate disease, researchers at UT Southwestern Medical Center say.

28 Jan 2007

Small molecule targets weak mRNA

A new strategy for fighting cancer aims to make its genes get lost in translation, according to a report in the January 26, 2007, issue of the journal Cell.

28 Jan 2007

Manipulation of proliferation and differentiation of human bone marrow derived neural stem cells in vitro and in vivo

Stem cells taken from adult human bone marrow have been manipulated by scientists at the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center to generate aggregates of cells called spheres that are similar to those derived from neural stem cells of the brain.

28 Jan 2007

50% of Americans have gene that affects how body burns sugar

A recent study by a Saint Louis University researcher confirms findings that about half of the U.S. population has a version of a gene that causes them to metabolize food differently, putting them at greater risk of developing diabetes.

28 Jan 2007

Chromatin plasticity gets a 3.7 Million Euro boost

The European Commission has awarded 3.7 Million Euro under the European Union Framework 6 Programme over the next four years to a new Marie Curie Research Training Network, coordinated by Dr. Andreas Ladurner at the European Molecular Biology Laboratory (EMBL).

24 Jan 2007

Scientists find surprising way of switching off a gene involved in cell division

Scientists at the University of Oxford have identified a surprising way of switching off a gene involved in cell division.

22 Jan 2007

Heska to sell allergy patents to Allergopharma

Heska Corporation has announced that it has completed the sale of its rights in a worldwide patent portfolio covering a number of major allergens and the genes that encode them to Allergopharma Joachim Ganzer KG for an undisclosed sum.

22 Jan 2007

Nanoparticles from crab shells show promise for drug delivery

Nanoparticles made of chitosan, a naturally occuring polymer isolated from crab and shrimp shells, have shown promise as carriers of anticancer drugs, antitumor genes, and other novel therapeutic agents.

22 Jan 2007

Simple diagnostic test detects genetic signs of lung cancer in sputum

DNA coughed up along with phlegm could point to lung cancer, say researchers at the University of Maryland School of Medicine who are developing an inexpensive and non-invasive gene probe to help diagnose early stage lung cancer in current and former smokers.

18 Jan 2007

Nanoparticles yield delivery tools for therapeutic nucleic acids

Cancer researchers hold great hope that nucleic acid-based therapeutics, such as anticancer genes, antisense oligonucleotides, and small interfering RNA (siRNA) molecules, will prove to be powerful antitumor agents.

16 Jan 2007

Variations in SORL1 gene may factor in development of Alzheimer's disease

Variations in a gene known as SORL1 may be a factor in the development of late onset Alzheimer's disease, an international team of researchers has discovered. The genetic clue, which could lead to a better understanding of one cause of Alzheimer's, is reported in Nature Genetics online, and was supported in part by the National Institutes of Health (NIH).

14 Jan 2007

Blue-green algae may lead to exciting class of anti-cancer drugs

Combining synthetic chemistry techniques with a knowledge of the properties and actions of enzymes, scientists have been able to produce an exciting class of anti-cancer drugs originally isolated from blue-green algae.

10 Jan 2007

Retinoblastoma gene may play a critical role in the development of the placenta

An important cancer-related gene may play a critical role in the development of the placenta, the organ that controls nutrient and oxygen exchange between a mother and her fetus during pregnancy, and perhaps in miscarriages.

10 Jan 2007

DNA methylation and breast cancer

A new study using mastectomy tissue shows that precancerous changes can occur in normal-appearing areas of the breast as distant as two inches from a tumor's edge.

10 Jan 2007

New approach offers hope for an effective herpes vaccine

A researcher at Montana State University has called for an innovative, new approach in developing a vaccine against genital herpes.

10 Jan 2007

Cartilage discovery offers arthritis hope

Scientists have revealed the intricate structure of cartilage in what they hope will provide clues to how the crippling joint disease osteoarthritis might one day be treated.

From The University of Manchester 10 Jan 2007

Several specific genetic alterations associated with development of smoking-related cancers

Preliminary research indicates that several specific genetic alterations are associated with the development of smoking-related head and neck skin cancers, according to a report in the January 10 issue of JAMA: The Journal of the American Medical Association.

9 Jan 2007

New hope for Krabbe disease sufferers

By all expectations, it shouldn't have worked as well as it did. A combination of bone marrow transplantation and gene therapy greatly lengthened the lives of laboratory mice doomed by a rapidly progressing, fatal neurodegenerative disorder also found in people.

9 Jan 2007

Test to detect drug-resistant HIV strains could help provide earlier treatment

A test to detect drug-resistant HIV strains in people with low levels of drug-resistant viral loads could help physicians provide more effective treatment earlier to HIV-positive people, according to a study published on Sunday in the online edition of the journal Nature Methods, BBC News reports.

9 Jan 2007