Atherosclerosis News and Research

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Atherosclerosis is the progressive buildup of plaque - the fatty deposits and other cells - in the inner walls of the arteries. The condition is a consequence of elevated cholesterol and for many it's a silent disease, with no visible signs or symptoms. The disease can begin in early adulthood and continues to progress for the rest of a person's life. Despite the serious nature of atherosclerosis, many people do not understand how it develops and progresses.

Transthyretin protein may accelerate atherosclerosis

Scientists report in the November 2007 issue of the Journal of Lipid Research that a protein called transthyretin (TTR) that is present in the blood may accelerate the development of atherosclerosis - a potentially fatal heart disease in which the arteries are progressively narrowed and hardened over time, reducing blood flow to the heart.

12 Oct 2007

Gene SIRT1 could lead to new cholesterol strategies

MIT researchers have discovered a link between a gene believed to promote long lifespan and a pathway that flushes cholesterol from the body. The finding could help researchers create drugs that lower the risk of diseases associated with high cholesterol, including atherosclerosis (clogged arteries) and Alzheimer's disease.

12 Oct 2007

Research shows how stem cells decide to become either skeletal or smooth muscle

Researchers have discovered a key protein that controls how stem cells "choose" to become either skeletal muscle cells that move limbs, or smooth muscle cells that support blood vessels, according to a study published in the Proceedings of the National Academy of Sciences (PNAS).

11 Oct 2007

High blood levels of C-reactive protein may be linked to increased risk of age-related macular degeneration

High blood levels of C-reactive protein, a substance linked to inflammation, appear to be associated with an increased risk for age-related macular degeneration, according to a report in the October issue of Archives of Ophthalmology, one of the JAMA/Archives journals.

9 Oct 2007

Heart disease of the left main coronary artery is often an inherited condition that clusters in families

Moreover, they discovered that initially healthy siblings of a person with the condition were 2.5 times more likely to go on to develop some form of heart disease than were siblings of a patient with heart disease that did not relate to the left main coronary artery.

4 Oct 2007

Depression, aging, and proteins made by a virus may all play role in heart disease

Researchers here have linked an increase in two immune system proteins essential for inflammation to a latent viral infection and proposed a chain of events that might accelerate cardiovascular disease.

2 Oct 2007

Ostructive sleep apnea and continuous positive airway pressure

Researchers in Brazil have found that treating patients who suffer from obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) dramatically reduces early indications of atherosclerosis in just months, linking OSA directly to the hardening or narrowing of the arteries.

29 Sep 2007

AGE-rich foods causes dysfunction linked to heart disease

A study in this month's Diabetes Care finds that ingesting food or drink rich in advanced glycation end products (AGEs) causes immediate, short-lived but significant endothelial dysfunction, shedding light on the mechanism by which dietary AGE content can be linked to cardiovascular disease.

27 Sep 2007

Coronary artery disease appears to increase prevalence of colorectal tumors

Patients in Hong Kong who were newly diagnosed with coronary artery disease had nearly twice the prevalence of colorectal tumors and cancers, with this association stronger in persons who had smoked or have the metabolic syndrome, according to a study in the Sept. 26 issue of JAMA: The Journal of the American Medical Association.

26 Sep 2007

Bad habits and lifestyle put heart disease victims at twice the risk of colon cancer

Researchers in Hong Kong have found that patients newly diagnosed with coronary artery disease had almost twice the prevalence of colorectal tumors and cancers; they say this was more so among those who had smoked or had metabolic syndrome.

25 Sep 2007

New device for clearing blocked arteries in the legs receives FDA approval

Cardiovascular Systems, Inc. (CSI) has announced that the U.S. Food and Drug Administration (FDA) has cleared the use of the Diamondback 360 Orbital Atherectomy System (OAS) for removing plaque blockages in the legs (peripherals) and restoring blood flow.

25 Sep 2007

Incidental findings found when radiologists take a 'broader' look at renal MR angiography

Radiologists need to look beyond the renal arteries when doing renal MR angiography (MRA), a study conducted at the Mayo Clinic in Rochester, MN suggests.

25 Sep 2007

Breakthrough in cardiovascular research

Cholesterol contributes to atherosclerosis - a condition that greatly increases the risk of heart attack and stroke - by suppressing the activity of a key protein that protects the heart and blood vessels, researchers at the Saint Louis University School of Medicine have found.

18 Sep 2007

Researchers look at role of oxidative stress in human diseases

Oxidative stress is known to underlie many human diseases including atherosclerosis, Parkinson's disease and Alzheimer's disease.

17 Sep 2007

Living, growing artificial heart-valve replacements for children

Infants and children receiving artificial heart-valve replacements face several repeat operations as they grow, since the since the replacements become too small and must be traded for bigger ones.

13 Sep 2007

Link between nicotine and atherosclerosis

It's well known that smoking cigarettes increases risk for a host of serious health problems from cancer to heart disease. Now a new study from Weill Cornell Medical College in New York City looks at how they do their dirty work by contributing to atherosclerosis, or hardening of the arteries. The evidence points to nicotine, the addictive chemical in cigarettes.

11 Sep 2007

Should I increase my vitamin E intake or not?

Conflicting reports about the potential benefits of dietary supplements can make a person's head spin.

11 Sep 2007

Concrete proof that public smoking bans work

At a major international conference in Edinburgh, Scotland, experts from around the world were given concrete proof that public smoking bans are effective when it comes to health benefits.

11 Sep 2007

A molecular probe that may one day light up tumors while surgery is in progress

Researchers at the Stanford University School of Medicine have developed a molecular probe that sets aglow tumor cells within living animals. Their goal is to use the probe to improve the diagnosis and treatment of cancer and other diseases.

10 Sep 2007

Gender (dis)advantages in cardiac remodeling

The topic of gender-related differences in cardiac care is an extremely complex one. Unfortunately women have been neglected in several fields of medicine for too long. I think that cardiology is only one of the many fields in the past where the male predominance was obvious.

3 Sep 2007