Precision Medicine News and Research

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Specific genetic errors that trigger congenital heart disease can be reproduced in common fruit fly

Specific genetic errors that trigger congenital heart disease (CHD) in humans can be reproduced reliably in Drosophila melanogaster - the common fruit fly - an initial step toward personalized therapies for patients in the future.

11 Feb 2017

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Researchers have identified a gatekeeper protein that prevents pancreatic cancer cells from transitioning into a particularly aggressive cell type and also found therapies capable of thwarting those cells when the gatekeeper is depleted.

9 Feb 2017

Study discovers new form of congenital muscular dystrophy caused by faulty INPP5K gene

A new form of congenital muscular dystrophy has been discovered which is caused by mutations in a previously un-linked gene.

9 Feb 2017

Researchers identify E. coli bacteria linking Crohn's disease to spondyloarthritis

Patients with Crohn's disease, a type of inflammatory bowel disease (IBD) that causes abdominal pain and diarrhea, can also experience joint pain.

9 Feb 2017

Horror movie scenes help researchers identify key neural pathway for processing fear

Researchers at the University of California, Irvine have identified a key neural pathway in humans that explains how the brain processes feelings of fear and anxiety, a finding that could help scientists unlock new ways to treat mental health disorders.

8 Feb 2017

NIH researchers identify genes that may predict how melanoma spreads

Cancerous tumors are voracious. Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells travel to other parts of the body (metastasize) to find more nourishment.

8 Feb 2017

Studies open new windows into understanding untreatable group of common genetic disorders

Two Princeton University studies are opening important new windows into understanding an untreatable group of common genetic disorders known as RASopathies that are characterized by distinct facial features, developmental delays, cognitive impairment and heart problems.

7 Feb 2017

Next-generation sequencing assay shows accuracy, sensitivity in detecting genetic mutations in tumors

One of the most promising areas of cancer research is personalized therapy using precision medicine. The National Cancer Institute's NCI-MATCH is a large, ongoing clinical trial that matches tumors to therapies based on the tumor's genetic characteristics.

7 Feb 2017

Scientists identify structure of androgenic receptor essential to fight against prostate cancer

A team led by researchers of the Institute of Biomedicine of the University of Barcelona and the Research Institute of the Hospital de la Santa Creu i Sant Paushows for the first time, the three-dimensional structure of the homodimeric androgen receptor ligand-binding domain, a structure that eluded researchers for years.

6 Feb 2017

Precision-medicine approach could improve accuracy of PSA-based prostate cancer screening tests

A new study led by researchers at UC San Francisco and Kaiser Permanente has identified genetic predictors of normal prostate-specific antigen (PSA) levels in healthy men, which could be used to improve the accuracy of PSA-based prostate cancer screening tests.

3 Feb 2017

New PET radiotracer effectively detects early and advanced stages of prostate cancer

In the featured article from the February 2017 issue of the Journal of Nuclear Medicine, researchers document the first-in-human application of a new imaging agent to help find prostate cancer in both early and advanced stages and plan treatment.

1 Feb 2017

European researchers highlight potential of xenografts in cancer research and treatment

European research lays the foundation for the development of new and ambitious research projects with xenografts derived from patients, preclinical models with great potential to advance research and treatment in cancer.

1 Feb 2017

New technology offers hope to millions suffering from tinnitus

As many as 50 million Americans suffer from tinnitus, a debilitating health condition commonly known as "ringing in the ears." Musicians, factory workers, military veterans and many others endure its effects, including problems with concentration, sleep, anxiety and depression.

31 Jan 2017

Experts update cystic fibrosis guidelines for better diagnosis and personalized treatment

An international research group of 32 experts from nine countries has updated the guidelines for diagnosing the genetic disease cystic fibrosis.

31 Jan 2017

Researchers develop online resource to gather, organize research information on cancer mutations

The body of knowledge on cancer genomics is massive and ever-expanding. But this wealth of potentially critical information is far less likely to be of help to patients if it is inaccessible to the doctors who treat them.

31 Jan 2017

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

A handful of FDA-approved drugs exist for treating individuals with alcohol use disorder but they have been largely ineffective at reducing the high rates of relapse. As such, there remains a critical need to identify and develop alternative pharmacological treatment options.

31 Jan 2017

Research provides new insights into epigenetic heterogeneity of Ewing sarcoma

Tumors of the elderly, such as breast cancer and colon cancer, accumulate thousands of DNA mutations.

31 Jan 2017

OHSU scientists uncover method for efficiently mapping genome of single cells in the body

OHSU scientists have uncovered a method for quickly and efficiently mapping the genome of single cells within the body. Their findings, to be published Jan. 30 in the journal Nature Methods, clears the way for a significant advance in precision medicine, including cancer, and many other disease areas.

30 Jan 2017

GUMC researchers describe lab technique to fill gaps in clinical care and research

Researchers who developed and tested a revolutionary laboratory technique that allows for the endless growth of normal and diseased cells in a laboratory are publicly sharing how the technique works.

28 Jan 2017

Interventions that change the brain may promote resilience and improved mental health

In an article published in the current issue of Psychotherapy and Psychosomatic Dr. Bruce McEwen (Rockefeller University) analyzes promising outlooks that interventions that affect brain may have on health.

28 Jan 2017

Precision Medicine News and Research

Specific genetic errors that trigger congenital heart disease can be reproduced in common fruit fly

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Study discovers new form of congenital muscular dystrophy caused by faulty INPP5K gene

Researchers identify E. coli bacteria linking Crohn's disease to spondyloarthritis

Horror movie scenes help researchers identify key neural pathway for processing fear

NIH researchers identify genes that may predict how melanoma spreads

Studies open new windows into understanding untreatable group of common genetic disorders

Next-generation sequencing assay shows accuracy, sensitivity in detecting genetic mutations in tumors

Scientists identify structure of androgenic receptor essential to fight against prostate cancer

Precision-medicine approach could improve accuracy of PSA-based prostate cancer screening tests

New PET radiotracer effectively detects early and advanced stages of prostate cancer

European researchers highlight potential of xenografts in cancer research and treatment

New technology offers hope to millions suffering from tinnitus

Experts update cystic fibrosis guidelines for better diagnosis and personalized treatment

Researchers develop online resource to gather, organize research information on cancer mutations

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

Research provides new insights into epigenetic heterogeneity of Ewing sarcoma

OHSU scientists uncover method for efficiently mapping genome of single cells in the body

GUMC researchers describe lab technique to fill gaps in clinical care and research

Interventions that change the brain may promote resilience and improved mental health

Editorial Focus eBook - Proteomics eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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