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AIDS might be an accident of evolution

The virulence characteristic of HIV-1 - the virus predominantly responsible for human AIDS - might amount to an accident of evolution, new evidence reveals.

18 Jun 2006

Scientists cracking virus protection shield

Scientists reveal the structure of a protein that packages the viral genome and helps viruses to replicate while avoiding human immune reactions

18 Jun 2006

Sonic hedgehog may help overcome problems associated with FGF2 and VEGF therapy

The newest concept for treating coronary artery disease is to induce hearts to grow their own new blood vessels to bypass damaged tissue or clogged arteries.

18 Jun 2006

From DNA to RNA to protein

Of the thousands of proteins produced in our cells, few are as important as the enzyme RNA polymerase (RNAP), which has the unique ability to faithfully copy genetic information from DNA.

18 Jun 2006

Transcription factors act not only in isolation to regulate distinct sets of genes

Scientists eager to help develop a new generation of pharmaceuticals are studying cellular proteins called transcription factors, which bind to upstream sequences of genes to turn the expression of those genes on or off.

18 Jun 2006

Researchers identify new keys to regulation of bacterial gene expression

The cellular process of transcription, in which the enzyme RNA polymerase constructs chains of RNA from information contained in DNA, depends upon previously underappreciated sections of both the DNA promoter region and RNA polymerase

18 Jun 2006

Researchers identify mechanism that regulates how many new cells are produced by each intestinal stem cell

Researchers at Karolinska Institutet have identified an important mechanism that regulates how many new cells are produced by each intestinal stem cell.

18 Jun 2006

Discovery of gene behind iron accumulation in brain has implications for Parkinson's, Alzheimer's

Oregon Health & Science University researchers have identified the gene behind a group of rare, progressive childhood disorders caused by an abnormal buildup of iron in the brain.

18 Jun 2006

Burkitt lymphoma gene expression signature identified

An international research study involving the University of Nebraska Medical Center, the National Cancer Institute and 10 other institutions has successfully identified the gene expression signature for Burkitt lymphoma.

14 Jun 2006

Dasatinib offers new options for leukemia patients

Dasatinib, an experimental drug under development by Bristol-Myers Squibb, reverses the signs and symptoms of patients whose chronic myeloid leukemia has failed to respond to Gleevec, which is considered the standard of treatment for the disorder.

14 Jun 2006

Scientists watch the behavior of a single gene in real time

Scientists at the Albert Einstein College of Medicine of Yeshiva University have observed for the first time that gene expression can occur in the form of discrete "pulses" of gene activity.

14 Jun 2006

Mechanism for neurodenegerative diseases linked to transport proteins

Hampering the transport of proteins within cells may underlie several adult-onset neurodegenerative diseases, such as Huntington's, ALS and Kennedy disease. Understanding how this cell transport is blocked in these diseases may offer targets for future therapy.

9 Jun 2006

Research explains how pathogenic bacteria evolved over millions of years

Bacteria like Salmonella have a complicated immune system that helps them recognize and isolate foreign DNA trying to invade their cell membrane, according to a University of Washington-led study in the June 8 issue of Science Express.

9 Jun 2006

Discovery of SLIRP gene could lead to cancer breakthroughs

Western Australian researchers have discovered a new gene that could lead to breakthroughs in breast and prostate cancer, as well as diabetes.

9 Jun 2006

"Mechanistic basis for understanding why we treat symptoms"

In the 1990s, the notion of "six degrees of separation" emphasized human linkages that connected people around the world.

9 Jun 2006

Potentially ground-breaking treatment for nerve damage caused by diabetes

The University of Manchester team has discovered that injection of a novel therapeutic that works by stimulating a person's genes may prevent nerve damage - primarily to the hands and feet - caused by the disease.

From The University of Manchester 8 Jun 2006

Lessons from our patients: development of a warm autopsy program

Thanks in large part to a dying patient's generosity, researchers have for the first time begun to analyze the progression of idiopathic pulmonary fibrosis (IPF), a degenerative illness distinguished by lung inflammation, scarring and diminished breathing capacity that typically leads to death within about five years of diagnosis.

7 Jun 2006