Malignant News and Research

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Combination of SYK and FLT3 enzymes promotes progression of acute myelogenous leukemia

Reinforcing the need to look beyond genomic alterations to understand the complexity of cancer, researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center report that a normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia (AML), to promote progression of the disease.

11 Feb 2014

Children who received radiation as part of treatment may have lower long-term survival rates, says study

The first comprehensive, large-scale cohort study of the long-term survival of children treated for low-grade gliomas, the most common pediatric brain tumor, finds that almost 90 percent are alive 20 years later and that few die from the tumor as adults.

4 Feb 2014

IDH1 gene mutation determines best treatment for malignant astrocytomas

Astrocytomas are the most common malignant brain tumors. While most patients' tumors prove to be quite aggressive, outcomes overall can vary widely, with some patients surviving for many years.

4 Feb 2014

RNAi-based screening offers MPM treatment hope

Research using RNA interference-based screening has identified several potential targets for the treatment of malignant pleural mesothelioma.

31 Jan 2014

Heart transplantation continues to be "gold standard" treatment for end-stage heart failure

Heart transplantation continues to be the "gold standard" treatment for end-stage heart failure, and a large number of patients now live 20 years or more after surgery, according to a study in the February 2014 issue of The Annals of Thoracic Surgery.

30 Jan 2014

Spontaneous tumorigenic transformation of human MSCs can occur during cell culture expansion

Researchers at Erasmus University Medical Center Rotterdam, The Netherlands, led by Dr. Qiuwei Pan and Dr. Luc van der Laan, have discovered that spontaneous tumorigenic transformation of human mesenchymal stem/stromal cells (MSCs) can occur during cell culture expansion, although the frequency is relatively low and often only observed after extensive passage in culture.

30 Jan 2014

Findings on molecular defects behind bladder cancer may pave way for new, targeted treatments

The once sketchy landscape of the molecular defects behind bladder cancer now resembles a road map to new, targeted treatments thanks to the unified efforts of scientists and physicians at 40 institutions.

30 Jan 2014

Research shows promise for developing a method of clearly identifying cancerous tissue during surgery

First-of-its-kind research by the Innovation Institute at Henry Ford Hospital shows promise for developing a method of clearly identifying cancerous tissue during surgery on one of the most common and deadliest types of brain tumor.

30 Jan 2014

UNC researchers develop new radiation-free ultrasound technique to detect, monitor cancer

While ultrasound provides a less expensive and radiation-free alternative to detecting and monitoring cancer compared to technologies such as X-rays, CT scans, and MRIs, ultrasound has seen limited use in cancer treatment due to clarity and resolution issues.

29 Jan 2014

Veterans with exposure to Agent Orange may be at higher risk for skin cancer

Vietnam War veterans with prior exposure to the herbicide Agent Orange may be at higher risk for certain types of skin cancer, suggests a report in the February issue of Plastic and Reconstructive Surgery-, the official medical journal of the American Society of Plastic Surgeons (ASPS).

29 Jan 2014

Researchers identify therapeutic target for cervix cancer

Gene related to the proliferation of cancerous cells blocked through molecular technology. A group of researchers from Mexico's General Hospital, Health Secretariat, Medicine Faculty and the Institute of Cellular Physiology of the National Autonomous University of Mexico (UNAM) identified a therapeutic target for cervix cancer: gene CDKN3.

28 Jan 2014

Specific compounds found in exhaled breath may help diagnose lung cancer in early stages

Specific compounds found in exhaled breath may help diagnose lung cancer in its early stages, according to a study released today at the 50th Annual Meeting of The Society of Thoracic Surgeons.

28 Jan 2014

BioTime: OncoCyte initiates clinical development of bladder cancer diagnostic test in U.S, China

BioTime, Inc. and its subsidiary OncoCyte Corporation today announced that OncoCyte has initiated clinical development of its bladder cancer diagnostic test in both the United States and China.

28 Jan 2014

Researchers develop novel compound known to reverse spread of malignant breast cancer cells

Researchers at Cardiff University are developing a novel compound known to reverse the spread of malignant breast cancer cells.

26 Jan 2014

Researchers identify important steps to understand mechanisms underlying pathogenic effect of prions

"When they are healthy, they look like tiny spheres; when they are malignant, they appear as cubes" stated Giuseppe Legname, principal investigator of the Prion Biology Laboratory at the Scuola Internazionale Superiore di Studi Avanzati (SISSA) in Trieste, when describing prion proteins.

25 Jan 2014

Clinical trial of experimental vaccine targets cancer stem cells in patients with recurrent brain tumor

An early-phase clinical trial of an experimental vaccine that targets cancer stem cells in patients with recurrent glioblastoma multiforme, the most common and aggressive malignant brain tumor, has been launched by researchers at Cedars-Sinai's Department of Neurosurgery, Johnnie L. Cochran, Jr. Brain Tumor Center and Department of Neurology.

25 Jan 2014

Scientists identify genetic alterations in pediatric soft-tissue cancer

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease. The study, by researchers at the National Cancer Institute, part of the National Institutes of Health, and their colleagues, appeared in the Jan. 23, 2014, issue of the journal Cancer Discovery.

24 Jan 2014

Scientists map genetic changes that drive tumors pediatric soft-tissue cancer

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes.

24 Jan 2014

Number of cancer stem cells in tumor might inaccurately estimate tumor's recurrence or progression

New research from The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) suggests that it may be the quality of cancer stem cells rather than their quantity that leads to better survival in certain patients with oral cancer.

23 Jan 2014

Advanced melanoma treatments: an interview with Dr. James Larkin, Consultant Medical Oncologist, The Royal Marsden

Advanced melanoma affects around 2,000 people per year in the UK. Advanced melanoma describes a melanoma that has spread from its site of origin to other areas of the body.

22 Jan 2014

Malignant News and Research

Combination of SYK and FLT3 enzymes promotes progression of acute myelogenous leukemia

Children who received radiation as part of treatment may have lower long-term survival rates, says study

IDH1 gene mutation determines best treatment for malignant astrocytomas

RNAi-based screening offers MPM treatment hope

Heart transplantation continues to be "gold standard" treatment for end-stage heart failure

Spontaneous tumorigenic transformation of human MSCs can occur during cell culture expansion

Findings on molecular defects behind bladder cancer may pave way for new, targeted treatments

Research shows promise for developing a method of clearly identifying cancerous tissue during surgery

UNC researchers develop new radiation-free ultrasound technique to detect, monitor cancer

Veterans with exposure to Agent Orange may be at higher risk for skin cancer

Researchers identify therapeutic target for cervix cancer

Specific compounds found in exhaled breath may help diagnose lung cancer in early stages

BioTime: OncoCyte initiates clinical development of bladder cancer diagnostic test in U.S, China

Researchers develop novel compound known to reverse spread of malignant breast cancer cells

Researchers identify important steps to understand mechanisms underlying pathogenic effect of prions

Clinical trial of experimental vaccine targets cancer stem cells in patients with recurrent brain tumor

Scientists identify genetic alterations in pediatric soft-tissue cancer

Scientists map genetic changes that drive tumors pediatric soft-tissue cancer

Number of cancer stem cells in tumor might inaccurately estimate tumor's recurrence or progression

Advanced melanoma treatments: an interview with Dr. James Larkin, Consultant Medical Oncologist, The Royal Marsden

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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