Genes News and Research

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Gene silencing protein discovered

A team of researchers, including biologists at Washington University in St. Louis, has discovered the key role one protein plays in a major turn-off -in this case, the turning off of thousands of nearly identical genes in a hybrid plant.

8 May 2006

A pericellular collagenase directs the 3-D development of white adipose tissue

In the journal Cell, researchers report the serendipitous discovery that the initial development of fat requires a "remodeling" protein that must first make way for the lipid-laden tissue's growth.

8 May 2006

Novel protein JHDM2A offers new look at male hormone regulation

For the second time in less than a year, University of North Carolina at Chapel Hill scientists have purified a novel protein and have shown it can alter gene activity by reversing a molecular modification previously thought permanent.

8 May 2006

New approaches to genetic disease, based on cells' own ability to correct themselves

New approaches to genetic disease, based on cells' own ability to correct themselves, will be outlined today at the annual conference of the European Society of Human Genetics in Amsterdam, The Netherlands.

8 May 2006

Discovery of gene that appears to play an important role in the onset of type 2 diabetes

In a painstaking set of experiments in overweight mice, scientists from the University of Wisconsin-Madison have discovered a gene that appears to play an important role in the onset of type 2 diabetes.

8 May 2006

MicroCT-based virtual histology

Utah and Texas researchers combined miniature medical CT scans with high-tech computer methods to produce detailed three-dimensional images of mouse embryos - an efficient new method to test the safety of medicines and learn how mutant genes cause birth defects or cancer.

8 May 2006

Important insights into how cells regulate certain growth-proteins

Researchers here have discovered a new mechanism used by cells - and manipulated by retroviruses - to control the making of certain essential proteins, including some involved in cancer.

8 May 2006

Mutated gene leads to JSRD

The research team, directed by Joseph Gleeson, M.D., Director of the Neurogenetics Laboratory at the UCSD School of Medicine and associate professor in the Department of Neurosciences, have identified a new gene that, when mutated, leads to JSRD. Their findings will be published on-line in advance of publication in the journal Nature Genetics.

8 May 2006

New technology to identify and engineer protease substrates

Researchers at UC Santa Barbara have developed a new biotechnology that enables scientists to identify and engineer protease substrates, giving them the means of crafting pharmaceuticals to outsmart disease.

3 May 2006

Therapeutic gene suspected to cause cancer

One of the few gene therapy studies that had ever been successful was terminated in 2003, because several of the treated children had developed leukemia.

3 May 2006

DARPA grant supports research toward realizing tissue regeneration

While U.S. soldiers fighting in Iraq and Afghanistan are surviving injuries that in previous conflicts likely would have been fatal, the number of wounded with major tissue loss has never before been so high.

3 May 2006

Hormones may affect how brain listens

From zebra fish to humans, reproductive hormones govern behavioral responses to courtship signals.

3 May 2006

Compensation by tumor suppressor genes during retinal development in mice and humans

Humans are more susceptible to developing the eye cancer retinoblastoma than mice because, unlike humans, mice can compensate for the loss of activity of a gene critical to normal retinal development, according to results of a study by investigators at St. Jude Children's Research Hospital.

3 May 2006

Scientists create leaner and meaner E. coli

By stripping the E. coli genome of vast tracts of its genetic material - hundreds of apparently inconsequential genes - a team of Wisconsin researchers has created a leaner and meaner version of the bacterium that is a workhorse of modern biology and industry.

3 May 2006

New study describes molecular basis of NeuroAIDS

Using multi-disciplinary analysis that included cognitive, neurophysiologic, virologic, and molecular techniques, the team found both a low-level viral infection in the brain and immune cells that had infiltrated the brain in order to protect against the virus.

3 May 2006

Comprehensive analysis of the human and mouse transcriptomes

An international consortium of scientists, including a team from The University of Queensland's Institute for Molecular Bioscience (IMB), is a step closer to the next generation of treatments to combat disease, after publishing a comprehensive analysis of the human and mouse transcriptomes.

3 May 2006