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Air quality in cities linked to inflammatory risk in diabetes

Exposure to traffic-related air pollutants is associated with a rapid increase in systemic inflammation in patients with diabetes, report Indian researchers.

30 Nov 2012

Fly model may help unravel genetic events that take place until development of a tumour

The wing of a fruit fly may hold the key to unraveling the genetic and molecular events that transform a normal cell into a cancerous one. The study, conducted on Drosophila melanogaster by scientists at the Institute for Research in Biomedicine (IRB Barcelona) and led by ICREA researcher Marco Mil-n, has reproduced each of the steps known to take place when a healthy cell turns cancerous.

30 Nov 2012

New insights into POT-1/TTP-1 protein complex

New insights into a protein complex that regulates the very tips of chromosomes could improve methods of screening anti-cancer drugs.

30 Nov 2012

Combination of chemotherapy and selumetinib shows promise against NSCLC

A new study by an international team of investigators led by Dana-Farber Cancer Institute scientists is the first to demonstrate that chemotherapy and a new, targeted therapy work better in combination than chemotherapy alone in treating patients with the most common genetic subtype of lung cancer.

30 Nov 2012

Two Sanford-Burnham projects win International Space Station Research Competition

Sanford-Burnham Medical Research Institute (Sanford-Burnham) today announced that two of the Institute's research teams have won Space Florida's International Space Station (ISS) Research Competition. Eight teams were selected from a pool of international applicants to send experiments to space in late 2013.

30 Nov 2012

New detection method can identify genetic switches associated with breast cancer

Physicians may now be better at detecting breast cancer than ever before, but much more work remains to ensure accurate diagnosis is possible and especially to assess future risk. That's why researchers from Germany have been working to develop a new test of gene action to predict cancer risk both at first diagnosis and into the future.

30 Nov 2012

UBE3B gene linked to brain development disorder in children

Researchers have defined the gene responsible for a rare developmental disorder in children. The team showed that rare variation in a gene involved in brain development causes the disorder. This is the first time that this gene, UBE3B, has been linked to a disease.

30 Nov 2012

Novel SIRT2 inhibitor protects against neuronal damage in animal models of Huntington's

Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended survival in two animal models of Huntington's disease.

30 Nov 2012

Epizyme to present data from DOT1L and EZH2 inhibitor programs at 54th ASH annual meeting

Epizyme, Inc., a biopharmaceutical company leading the creation of personalized therapeutics to treat patients with genetically defined cancers, today announced the presentation of data evaluating the preclinical safety and efficacy of two of the Company's novel, potent and selective small molecule inhibitors. These inhibitors individually target DOT1L and EZH2, members of a class of epigenic enzymes called histone methyltransferases (HMTs).

30 Nov 2012

Modified vitamin D receptor may reduce risk of osteoporosis

Osteoporosis, or reduced bone mineral density that can increase the risk of fractures, may affect as many as 30% of women and 12% of men worldwide. One risk factor for osteoporosis is vitamin D deficiency.

30 Nov 2012

Alberta Children's Hospital performs first liver cell transplant in Calgary, Canada

A three-month-old Winnipeg girl has become the first patient in Canada to receive an experimental and potentially life-saving form of therapy to improve the function of her liver.

29 Nov 2012

AstraZeneca receives FDA approval for Cometriq to treat medullary thyroid cancer

The U.S. Food and Drug Administration today approved Cometriq (cabozantinib) to treat medullary thyroid cancer that has spread to other parts of the body (metastasized).

29 Nov 2012

Study shows how PTPN22 variant linked with T1D influences susceptibility to autoimmunity

As part of their ongoing research on the role of genes in the development of type 1 diabetes, Joslin Diabetes Center scientists, in collaboration with scientists at the University of Würzburg, have demonstrated how a genetic variant associated with type 1 diabetes and other autoimmune diseases influences susceptibility to autoimmunity. The findings appear in the upcoming issue of Diabetes.

29 Nov 2012

DLKI-DIO3 miRNA cluster suppresses spread of cancer from its primary site

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered a group of what have been considered relatively minor regulators in the body that band together to suppress the spread of cancer from its primary site.

29 Nov 2012

Majority of parents with autistic child show interest in having genetic tests

The vast majority (80 percent) of parents with at least one child with Autism Spectrum Disorder (ASD) would pursue genetic testing if a test were available that could identify risk in a younger sibling, citing the desire for earlier identification of children at risk, earlier evaluation and intervention, closer monitoring and lessened anxiety.

29 Nov 2012

Risk score predicts childhood obesity in newborns

Researchers have developed a tool to assess a newborn baby’s risk for child or adolescent obesity based on various demographic characteristics.

29 Nov 2012

New antifungal drugs could be developed based on substance bacteria use to decompose mushrooms

Soft rot diseases cause a great deal of damage in agriculture, and turn fruits, vegetables, and mushrooms to mush. By using imaging mass spectrometry together with genetic and bioinformatic techniques (genome mining), German researchers have now discovered the substance the bacteria use to decompose mushrooms.

29 Nov 2012

Childhood obesity risk can be predicted at birth

A simple formula can predict at birth a baby's likelihood of becoming obese in childhood, according to a study published today in the open access journal PLOS ONE.

29 Nov 2012

microRNA-223 molecule plays a surprising role in protecting brain cells from stroke effects

A small molecule known to regulate white blood cells has a surprising second role in protecting brain cells from the deleterious effects of stroke, Johns Hopkins researchers report. The molecule, microRNA-223, affects how cells respond to the temporary loss of blood supply brought on by stroke - and thus the cells' likelihood of suffering permanent damage.

29 Nov 2012

Tadalafil may offer therapeutic strategy in patients with Becker muscular dystrophy

Cedars-Sinai Heart Institute researchers have found in an initial clinical trial that a drug typically prescribed for erectile dysfunction or pulmonary hypertension restores blood flow to oxygen-starved muscles in patients with a type of muscular dystrophy that affects males, typically starting in childhood or adolescence.

29 Nov 2012

Genetic News and Research

Air quality in cities linked to inflammatory risk in diabetes

Fly model may help unravel genetic events that take place until development of a tumour

New insights into POT-1/TTP-1 protein complex

Combination of chemotherapy and selumetinib shows promise against NSCLC

Two Sanford-Burnham projects win International Space Station Research Competition

New detection method can identify genetic switches associated with breast cancer

UBE3B gene linked to brain development disorder in children

Novel SIRT2 inhibitor protects against neuronal damage in animal models of Huntington's

Epizyme to present data from DOT1L and EZH2 inhibitor programs at 54th ASH annual meeting

Modified vitamin D receptor may reduce risk of osteoporosis

Alberta Children's Hospital performs first liver cell transplant in Calgary, Canada

AstraZeneca receives FDA approval for Cometriq to treat medullary thyroid cancer

Study shows how PTPN22 variant linked with T1D influences susceptibility to autoimmunity

DLKI-DIO3 miRNA cluster suppresses spread of cancer from its primary site

Majority of parents with autistic child show interest in having genetic tests

Risk score predicts childhood obesity in newborns

New antifungal drugs could be developed based on substance bacteria use to decompose mushrooms

Childhood obesity risk can be predicted at birth

microRNA-223 molecule plays a surprising role in protecting brain cells from stroke effects

Tadalafil may offer therapeutic strategy in patients with Becker muscular dystrophy

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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