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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Array BioPharma reports top-line results from binimetinib Phase 3 trial in patients with NRAS-mutant melanoma

Array BioPharma today reported top-line results from the ongoing Phase 3 clinical trial of binimetinib in patients with advanced NRAS-mutant melanoma, known as the NEMO trial. The study met its primary endpoint of improving progression-free survival (PFS) compared with dacarbazine treatment.

16 Dec 2015

Study points to future treatment for post-stroke damage

A study of rats released today shows that blocking a type of RNA produced by what used to be called "junk DNA" can prevent a significant portion of the neural destruction that follows a stroke. The research points toward a future treatment for post-stroke damage, which is often more extensive than the initial destruction that results when blood to the brain is temporarily shut off.

16 Dec 2015

CTE can be diagnosed by neuropathological examination of brain tissue

For the first time, CTE has been confirmed as a unique disease that can be definitively diagnosed by neuropathological examination of brain tissue. A consensus panel of expert neuropathologists concluded that CTE has a pathognomonic signature in the brain, an advance that represents a milestone for CTE research and lays the foundation for future studies defining the clinical symptoms, genetic risk factors and therapeutic strategies for CTE.

16 Dec 2015

TSRI scientists track how HIV-fighting antibodies develop over time

In a new study, a team led by scientists at The Scripps Research Institute tracked how a family of these HIV-fighting antibodies develops over time. The research shows how a future vaccine might trigger the immune system to produce these antibodies more effectively.

16 Dec 2015

Prophylaxis treatment can protect children who receive liver transplants from HBV-infected donors

Researchers have found that a prophylaxis treatment can prevent new-onset hepatitis B in children who receive liver transplants from donors who were previously infected with hepatitis B virus (HBV) but had successfully cleared the virus.

16 Dec 2015

Heloise Anne Pereira named 2016 National Academy of Inventors Fellow

University of Oklahoma Health Sciences Center Professor Heloise Anne Pereira has been named a 2016 National Academy of Inventors Fellow, a high professional distinction awarded to academic inventors who have demonstrated a prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development and the welfare of society.

16 Dec 2015

Cancer drug may protect kidneys from damage caused by chemotherapy agent cisplatin

A class of drugs used increasingly to help fight cancer may have the additional benefit of protecting the kidneys when packaged with the powerful chemotherapy agent cisplatin.

16 Dec 2015

Sample Preparation for LC/MS

Porvair Sciences offer a range of sample evaporators and microplate products optimised for use in conjunction with LC/MS and LC/MS/MS instrumentation.

From Porvair Sciences Limited 15 Dec 2015

VCU Massey Cancer Center scientists reveal signaling process that leads to excessive growth of cancer

The gene p53 has been described as the "guardian of the genome" due to its prominent role in preventing genetic mutations. More than half of all cancers are thought to originate from p53 mutations or loss of function, and now a recent study by VCU Massey Cancer Center scientist Richard Moran, Ph.D., explains why.

15 Dec 2015

Gene variant linked to psychotic symptoms, cognitive impairment in people with bipolar disorder identified

Researchers at Karolinska Institutet, and the Sahlgrenska Academy at Gothenburg University in Sweden have identified a gene variant linked to psychotic symptoms and cognitive impairment in people with bipolar disorder. The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

15 Dec 2015

Lupuzor may become first non-immunosuppressant therapy for lupus

Lupuzor may become the first specific and non-immunosuppressant therapy for lupus, a disabling autoimmune disease that is currently incurable.

15 Dec 2015

Researchers discover novel way to enhance, restore cancer suppressor activity in B-ALL

Researchers at Penn State College of Medicine, working with Chinese and American colleagues, have discovered a novel way to enhance and restore cancer suppressor activity in B-cell acute lymphoblastic leukemia, resulting in better outcomes in a pre-clinical model of the disease. The finding could pave the way for a new class of drugs for this and other forms of leukemia.

15 Dec 2015

Liver protein aids in accelerating growth of insulin-producing pancreatic 'beta' cells

More than a quarter of the 30 million people with diabetes in the United States depend on daily injections of insulin to maintain their blood glucose levels in a healthy range. Scientists are investigating many techniques to help treat or potentially even cure many of these patients by increasing the body's own insulin-producing pancreatic "beta" cells.

15 Dec 2015

CAP2 gene responsible for cardiac conduction disease in mice

The presence or absence of the CAP2 gene causes sudden cardiac death in mice, according to new research from the Perelman School of Medicine at the University of Pennsylvania. In particular, the absence of the gene interrupts the animal's ability to send electrical signals to the heart to tell it to contract, a condition called cardiac conduction disease.

15 Dec 2015

Study may help reduce sugar consumption, improve nutritional health of children

Everyone knows that children love sweets, but ever wonder why some kids seem to want more sugary food than others? It could be because they need more sugar to get that same sweet taste. According to new research from the Monell Center, sensitivity to sweet taste varies widely across school-aged children and is in part genetically-determined.

15 Dec 2015

Genes vital for age-related cognitive declines in memory identified in adult worm neurons

Researchers from Princeton University have identified genes important for age-related cognitive declines in memory in adult worm neurons, which had not been studied previously. The research, published in the journal Nature, could eventually point the way toward therapies to extend life and enhance health in aging human populations.

15 Dec 2015

Antibiotic resistance may help find drugs to combat amyloid formation

Amyloid diseases such as Parkinson's, Alzheimer's and type-2 diabetes pose a particular problem for drug designers because they do not present a clear target structure to aim at.

15 Dec 2015

Human body clock study paves way for drug treatment of osteoarthritis

A University of Manchester biologist has for the first time established that the painful and debilitating symptoms endured by osteoarthritis sufferers are intrinsically linked to the human body clock.

15 Dec 2015

Light-driven protein has potential to become key tool for optogenetics

Biophysicists have developed a hypothesis to explain the function of a light-driven protein which pumps sodium ions across a cell membrane, and they have revealed the key structural feature of these pumps. The scientists see these sodium pumps as being highly promising tools in using light signals to control nerve cells – which is exactly what is involved in the new scientific field of optogenetics.

15 Dec 2015

Researchers trace origins of early abnormal brain overgrowth in ASD

Further underscoring the prenatal origins of Autism Spectrum Disorder (ASD), researchers at University of California, San Diego School of Medicine describe for the first time how abnormal gene activity in cell cycle networks that are known to control brain cell production may underlie abnormal early brain growth in the disorder.

14 Dec 2015

Protein News and Research

Further Reading

Array BioPharma reports top-line results from binimetinib Phase 3 trial in patients with NRAS-mutant melanoma

Study points to future treatment for post-stroke damage

CTE can be diagnosed by neuropathological examination of brain tissue

TSRI scientists track how HIV-fighting antibodies develop over time

Prophylaxis treatment can protect children who receive liver transplants from HBV-infected donors

Heloise Anne Pereira named 2016 National Academy of Inventors Fellow

Cancer drug may protect kidneys from damage caused by chemotherapy agent cisplatin

Sample Preparation for LC/MS

VCU Massey Cancer Center scientists reveal signaling process that leads to excessive growth of cancer

Gene variant linked to psychotic symptoms, cognitive impairment in people with bipolar disorder identified

Lupuzor may become first non-immunosuppressant therapy for lupus

Researchers discover novel way to enhance, restore cancer suppressor activity in B-ALL

Liver protein aids in accelerating growth of insulin-producing pancreatic 'beta' cells

CAP2 gene responsible for cardiac conduction disease in mice

Study may help reduce sugar consumption, improve nutritional health of children

Genes vital for age-related cognitive declines in memory identified in adult worm neurons

Antibiotic resistance may help find drugs to combat amyloid formation

Human body clock study paves way for drug treatment of osteoarthritis

Light-driven protein has potential to become key tool for optogenetics

Researchers trace origins of early abnormal brain overgrowth in ASD

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