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Diabetes interventions show promise in primary care

Two lifestyle-based diabetes interventions developed in a clinical trial could successfully promote weight loss in primary care, research shows.

28 Dec 2012

US acute kidney injury deaths ‘double in past decade’

A US study has found that the most severe form of acute kidney injury has increased nationwide by an average 10% per year with the number of associated deaths doubling over the past decade.

28 Dec 2012

New light on how epigenetic signals may function together to determine fate of stem cell

Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.

28 Dec 2012

Researchers sequence entire gene to identify mutations that cause hyperinsulinism

Congenital hyperinsulinism is a genetic condition where a baby's pancreas secretes too much insulin. It affects approximately one in 50,000 live births and in severe cases requires the surgical removal of all or part of the pancreas.

28 Dec 2012

Bariatric surgery succeeds when new year resolutions to lose weight fail

For years Blanca Ramirez, like many Americans, started each new year with a resolution to lose weight. But no more. "I lost 55 pounds this year and the weight is rolling off and will stay off," said the 42 year-old, married, mother of three. Ramirez underwent bariatric surgery at Loyola Center for Metabolic Surgery & Bariatric Care in August and has lost 55 pounds in four months.

28 Dec 2012

Juxtapid receives FDA approval for treatment of rare cholesterol disorder

On Dec. 21, the U.S. Food and Drug Administration approved Juxtapid (lomitapide) to reduce low-density lipoprotein (LDL) cholesterol, total cholesterol, apolipoprotein B, and non-high-density lipoprotein (non-HDL) cholesterol in patients with homozygous familial hypercholesterolemia (HoFH). Juxtapid is intended for use in combination with a low fat diet and other lipid-lowering treatments.

27 Dec 2012

Study on prevalence of coronary atherosclerosis among U.S. soldiers

Among deployed U.S. service members who died of combat or unintentional injuries between 2001-2011 and underwent autopsies, the prevalence of coronary atherosclerosis was 8.5 percent, with factors associated with a higher prevalence of the disease including older age, lower educational level and prior diagnoses of dyslipidemia, hypertension, and obesity, according to a study in the December 26 issue of JAMA.

26 Dec 2012

Survey reveals significant improvement in delivery of underused care

An analysis of nationally representative survey data found significant improvement in the delivery of underused care, but more limited changes in the reduction of inappropriate care in ambulatory health care settings between 1998 and 2009, according to a report published Online First by Archives of Internal Medicine, a JAMA Network publication.

25 Dec 2012

Blood transfusion for patients with myocardial infarction associated with increased all-cause mortality

A meta-analysis of 10 studies suggests that receipt of a blood transfusion among patients with myocardial infarction (heart attack) was associated with increased all-cause mortality compared with not receiving a blood transfusion during heart attack, according to a report published Online First by Archives of Internal Medicine, a JAMA Network publication.

25 Dec 2012

Blood transfusion may increase risk of death in heart attack patients with anemia

When heart attack patients present in the emergency department with some degree of anemia, or anemic patients have a heart attack, physicians have a tendency, but not much guidance, about whether to provide a blood transfusion.

25 Dec 2012

Diuretic-based antihypertensive therapy touted for obese

Diuretic-based antihypertensive regimens may be preferable to calcium channel blocker-based therapy in patients who are obese, suggest researchers writing in The Lancet.

24 Dec 2012

More children surviving heart attacks in hospital

Approximately three times more children survived in-hospital cardiac arrest in 2009 compared with 2000, indicate data from the Get With The Guidelines–Resuscitation registry.

24 Dec 2012

Comorbidity could alter joint arthroplasty prognosis

The long-term outcome of hip and knee arthroplasty may be significantly influenced by comorbidity, suggest results from a large register-based study of over 96,000 osteoarthritis patients.

22 Dec 2012

BCPR, Orexigen partner to accelerate patient enrollment for Contrave obesity Light Study

Blue Chip Patient Recruitment, a division of Blue Chip Marketing Worldwide, a full-service integrated marketing agency, has successfully partnered with Orexigen Therapeutics to accelerate patient enrollment of The Light Study, Orexigen's cardiovascular outcomes trial evaluating Contrave (naltrexone sustained release (SR)/bupropion SR).

21 Dec 2012

Gene therapy shows promise for severe coronary artery disease

Diagnosed with severe coronary artery disease, a group of patients too ill for or not responding to other treatment options decided to take part in a clinical trial testing angiogenic gene therapy to help rebuild their damaged blood vessels.

21 Dec 2012

New Nationwide Children's exercise program for pediatric cancer survivors

There are many health effects that a patient may need to overcome after winning a battle against cancer. Cancer treatments can affect the patient's balance, agility, coordination, prompt weight gain and other physical ailments. At Nationwide Children's Hospital, beating cancer doesn't mark the end of a child's treatment regimen. A new exercise program at the hospital helps pediatric cancer survivors and those in remission regain both physical strength and confidence.

21 Dec 2012

Researcher looks at role of TIMP3 protein linked with aortic aneurysms in the abdomen

A researcher with the Faculty of Medicine & Dentistry and the Mazankowski Alberta Heart Institute is looking closely at a molecule linked to aortic aneurysms in the abdomen, and her findings could lead to a treatment to reduce swelling of the aortic artery, which would be a life-saving treatment.

21 Dec 2012

New technique may prevent inheritance of mitochondrial diseases in children

A joint team of scientists from The New York Stem Cell Foundation (NYSCF) Laboratory and Columbia University Medical Center (CUMC) has developed a technique that may prevent the inheritance of mitochondrial diseases in children.

21 Dec 2012

Study shows how to prod stem cells to become 2 different types of blood vessel tissues

Growing new blood vessels in the lab is a tough challenge, but a Johns Hopkins engineering team has solved a major stumbling block: how to prod stem cells to become two different types of tissue that are needed to build tiny networks of veins and arteries.

21 Dec 2012

Longer looks: Disparities in nursing home penalties; Understanding dying with dignity

My mortality wake-up call came in a hospital after knee surgery, when I flat-lined because of a heart arrhythmia and was resuscitated by a nurse. In response to columns about those events, stories have streamed in from people who are running out of time themselves, or enduring the pain of watching loved ones fade. The deaths they face are as different as the lives they've lived, but a steady refrain runs through their emails and letters.

21 Dec 2012

Heart News and Research

Diabetes interventions show promise in primary care

US acute kidney injury deaths ‘double in past decade’

New light on how epigenetic signals may function together to determine fate of stem cell

Researchers sequence entire gene to identify mutations that cause hyperinsulinism

Bariatric surgery succeeds when new year resolutions to lose weight fail

Juxtapid receives FDA approval for treatment of rare cholesterol disorder

Study on prevalence of coronary atherosclerosis among U.S. soldiers

Survey reveals significant improvement in delivery of underused care

Blood transfusion for patients with myocardial infarction associated with increased all-cause mortality

Blood transfusion may increase risk of death in heart attack patients with anemia

Diuretic-based antihypertensive therapy touted for obese

More children surviving heart attacks in hospital

Comorbidity could alter joint arthroplasty prognosis

BCPR, Orexigen partner to accelerate patient enrollment for Contrave obesity Light Study

Gene therapy shows promise for severe coronary artery disease

New Nationwide Children's exercise program for pediatric cancer survivors

Researcher looks at role of TIMP3 protein linked with aortic aneurysms in the abdomen

New technique may prevent inheritance of mitochondrial diseases in children

Study shows how to prod stem cells to become 2 different types of blood vessel tissues

Longer looks: Disparities in nursing home penalties; Understanding dying with dignity

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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