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Research reveals role of colon signaling pathway in development of IBD

The intestine encounters more foreign substances, and potential toxins, than other parts of the body, so it is not surprising that a healthy gut is maintained by the tight control of immune responses.

30 Mar 2018

Salk scientists discover protein that 'turns off' uncontrolled liver cancer growth

Salk Institute scientists, together with researchers from Switzerland's University of Basel and University Hospital Basel, discovered a protein called LHPP that acts as a molecular switch to turn off the uncontrolled growth of cells in liver cancer.

29 Mar 2018

Researchers develop novel approach to fighting ovarian cancer

Researchers have discovered a cellular pathway that selectively regulates a mutant protein linked to the growth of ovarian cancer.

29 Mar 2018

Cell-penetrating 'nanodrills' could be new platform for intracellular drug delivery

Researchers at Oregon State University and Oregon Health & Science University have created new nanomaterials able to cross cell membranes, establishing a novel platform for the intracellular delivery of molecular drugs and other cargo.

27 Mar 2018

Genetic mutation that may protect people from malaria found to be more common

A genetic mutation that may protect people from malaria, but was thought to be rare, is surprisingly common, suggest the findings of a new study led by scientists at The Scripps Research Institute.

23 Mar 2018

Specific immune cells may help slow progression of ALS, research shows

New research into Amyotrophic Lateral Sclerosis (ALS) - also known as motor neuron disease - shows that specific immune cells may help slow progression of the disease, an important step towards developing new therapies to treat patients.

22 Mar 2018

Researchers show how two cancer genes work together to trigger leukemia

An international group of researchers led by Prof. Jan Cools of the VIB-KU Leuven Center for Cancer Biology have made a breakthrough in understanding the development of acute lymphoblastic leukemia, an aggressive cancer of the blood.

20 Mar 2018

Study shows benefits of hair loss drug in improving cognitive function and vascular health

Minoxidil, a popular drug used on the scalp to treat hair loss, might improve blood flow to the brain, lower blood pressure and increase elasticity in the blood vessels if taken in an oral form, according to a new study in mice.

20 Mar 2018

Viagra cuts colorectal cancer risk in animal model

A small, daily dose of Viagra significantly reduces colorectal cancer risk in an animal model that is genetically predetermined to have the third leading cause of cancer death, scientists report.

19 Mar 2018

Research establishes use of chimeric cells as potential therapy for Duchenne muscular dystrophy

Cells made by fusing a normal human muscle cell with a muscle cell from a person with Duchenne muscular dystrophy --a rare but fatal form of muscular dystrophy -- were able to significantly improve muscle function when implanted into the muscles of a mouse model of the disease.

16 Mar 2018

IBN’s green tea-based drug nanocarriers show superior tumor-killing performance

The Institute of Bioengineering and Nanotechnology of A*STAR has reported superior results using new green tea-based nanocarriers to kill liver cancer cells, compared to existing drug delivery systems.

16 Mar 2018

Transplanting enhanced interneurons restores brain rhythms in mouse model of Alzheimer’s

Like a great orchestra, your brain relies on the perfect coordination of many elements to function properly. And if one of those elements is out of sync, it affects the entire ensemble. In Alzheimer's disease, for instance, damage to specific neurons can alter brainwave rhythms and cause a loss of cognitive functions.

15 Mar 2018

Tumor's 'microenvironment' plays key role in altering therapeutic response of breast cancer

Cancer is typically thought of as a tumor that needs to be removed or an area that needs to be treated with radiation or chemotherapy. As a physicist and cancer researcher, Joe Gray, Ph.D., thinks differently.

14 Mar 2018

Surprise discovery may lead potential treatment for multiple sclerosis

A surprise finding by medical scientists may lead to the development of a possible treatment for multiple sclerosis (MS).

9 Mar 2018

TSRI researchers show path to developing treatments for Charcot-Marie-Tooth disease

Scientists at The Scripps Research Institute have now shown a path to developing treatments for disease subtype CMT2D.

8 Mar 2018

New study examines origin of cryptococcosis within the central nervous system

A particular fungal infection is responsible for more than 220,000 cases of cryptococcosis worldwide each year in people with HIV and AIDS, with nearly 181,000 of those resulting in death.

8 Mar 2018

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

Sanford Burnham Prebys Medical Research Institute researchers have published two new studies in Neuron that describe how TREM2, a receptor found on immune cells in the brain, interacts with toxic amyloid beta proteins to restore neurological function.

8 Mar 2018

Researchers determine cause of difficult-to-control mitochondrial diseases

A Japanese research group has discovered that taurine is conjugated with mitochondrial transfer RNAs (tRNAs), small RNAs that decode genetic information, and that taurine deficiency in tRNA dramatically reduces both mitochondrial protein translation and impairs mitochondrial membrane integrity.

7 Mar 2018

Researchers reveal new molecular target to help ease asthma symptoms

Researchers at UC Davis Health and Albany Medical College have shown that the protein vascular endothelial growth factor A -- or VEGFA -- plays a major role in the inflammation and airway obstruction associated with asthma.

7 Mar 2018

Preventing metabolic exhaustion in immune cells could enhance effects of immunotherapy

If you're an immune cell gearing up to fight cancer, you'd better eat your breakfast. The tumor microenvironment is a harsh place, and tumor cells are ready to wear you out.

6 Mar 2018

Mouse Model News and Research

Research reveals role of colon signaling pathway in development of IBD

Salk scientists discover protein that 'turns off' uncontrolled liver cancer growth

Researchers develop novel approach to fighting ovarian cancer

Cell-penetrating 'nanodrills' could be new platform for intracellular drug delivery

Genetic mutation that may protect people from malaria found to be more common

Specific immune cells may help slow progression of ALS, research shows

Researchers show how two cancer genes work together to trigger leukemia

Study shows benefits of hair loss drug in improving cognitive function and vascular health

Viagra cuts colorectal cancer risk in animal model

Research establishes use of chimeric cells as potential therapy for Duchenne muscular dystrophy

IBN’s green tea-based drug nanocarriers show superior tumor-killing performance

Transplanting enhanced interneurons restores brain rhythms in mouse model of Alzheimer’s

Tumor's 'microenvironment' plays key role in altering therapeutic response of breast cancer

Surprise discovery may lead potential treatment for multiple sclerosis

TSRI researchers show path to developing treatments for Charcot-Marie-Tooth disease

New study examines origin of cryptococcosis within the central nervous system

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

Researchers determine cause of difficult-to-control mitochondrial diseases

Researchers reveal new molecular target to help ease asthma symptoms

Preventing metabolic exhaustion in immune cells could enhance effects of immunotherapy

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