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Researchers uncover the potential of JAK inhibitors to treat life-threatening skin disease

Researchers identified Janus kinase inhibitors as a promising treatment for the severe drug-induced skin condition toxic epidermal necrolysis, by analyzing patient biopsies with deep visual proteomics.

17 Oct 2024

Study reveals gender differences in Rett syndrome progression

A new UC Davis MIND Institute study offers critical insights into Rett syndrome, a rare genetic condition that affects mostly girls.

17 Oct 2024

New grant aims to transform treatment for liver cancer

Currently, there are a few available treatment options for liver cancer, including a combination of immunotherapies and a class of drugs known as tyrosine kinase inhibitors (TKIs), but their long-term effects are limited.

17 Oct 2024

Molecular chaperones as key players in tumor suppressor stability

A new review was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Molecular chaperones: Guardians of tumor suppressor stability and function."

16 Oct 2024

Study reveals genetic factors affecting birth sex ratios

Each year, roughly the same numbers of boys and girls are born.

16 Oct 2024

Zebrafish could be used to explore the underlying mechanisms of Nager syndrome

Nager syndrome, or NS, is a rare genetic disease that affects the development of the face and limbs, usually causing anomalies in the bone structures of the jaws, cheeks, and hands.

16 Oct 2024

Bacteriophages unveil auxiliary genes critical for infection

Viruses that infect bacteria—known as bacteriophages - could be used in a targeted manner to combat bacterial diseases.

16 Oct 2024

Transposons play essential role in early human development

A critical transition in early human development is regulated not by our own genes, but by DNA elements called transposons that can move around the genome, Sinai Health researchers have found.

16 Oct 2024

Induced resistance as a path to sustainable food security

As the climate crisis alters familiar growing conditions, we urgently need to find ways of protecting the world against famines.

16 Oct 2024

Researchers identify shared genetic variants between testosterone traits and PCOS

A genome-wide study reveals significant genetic overlap between polycystic ovary syndrome and testosterone-related traits, highlighting shared causal variants.

16 Oct 2024

Shift Bioscience raises $16 M to advance cell simulation AI platform

Shift Bioscience is a biotech company using generative AI models to understand how activation of different genes can reverse the aging process. This research is a fundamental step forward in designing more effective drugs to treat age-related diseases.

From Shift Bioscience 16 Oct 2024

Researchers uncover distinct cell vulnerabilities in Alzheimer’s progression with novel multiomics approach

Researchers used single-cell and spatial genomics to map cell-type-specific changes in the middle temporal gyrus, identifying distinct disease phases in Alzheimer’s progression.

16 Oct 2024

Gene editing restores treatment sensitivity in melanoma

In a potential advance for melanoma patients, researchers at ChristianaCare’s Gene Editing Institute have used CRISPR gene editing tools to disable a gene mutation often seen in aggressive forms of this dangerous skin cancer that renders promising treatments ineffective.

16 Oct 2024

Historical review reveals French contributions to depression research

In an era where mental health awareness is at the forefront of public discourse, a new historical review is shedding light on the often-overlooked French contributions to our understanding of depression.

16 Oct 2024

Harnessing the power of miRNA for cancer diagnosis and treatment

This study is led by Dr. Shiwei Duan (Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China). His team analyzed literature on miRNA, summarizing the close relationship between these small molecules and cancer. miRNA is a type of non-coding RNA that does not encode proteins, but can target more than 60% of human protein-coding genes.

15 Oct 2024

DNA changes from high potency cannabis use may signal psychosis risk

Published in Molecular Psychiatry, this is the first study to suggest that the use of high potency cannabis leaves a distinct mark on DNA, providing valuable insights into the biological impact of cannabis use.

15 Oct 2024

Genetic insights transform treatment for children with developmental disorders

Thousands of children with severe developmental disorders have benefited from more targeted treatments and support with genetic insights from the large-scale Deciphering Developmental Disorders (DDD) study, finds a new study.

15 Oct 2024

New insights into pain mechanisms related to viral infections

An article published in the journal Brain, Behavior, and Immunity reports the findings of a study by researchers based in Brazil, the United States and South Korea who set out to understand how viral infections cause pain and to contribute to the search for novel ways of relieving it.

15 Oct 2024

Genetics identified as key factor in gout development

A major international study has found gout is a chronic illness where genetics is a major cause, rather than lifestyle choices of the sufferer.

15 Oct 2024

Scripps Research identifies binding site on challenging cancer protein

Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate.

15 Oct 2024