Mouse Model News and Research

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Bariatric surgery successes pave way for new type 2 diabetes treatment

Bariatric surgery has long yielded almost immediate health benefits for patients with type 2 diabetes, and new findings on the reasons for remission may be the key to developing drug alternatives to surgery.

25 Apr 2018

Innovative research could lead to new ways to treat, prevent cancer

Research into cancer can provide new insight into how this disease works and how it can be stopped. The Experimental Biology 2018 meeting will showcase innovative research that could lead to new ways to treat and prevent cancer.

23 Apr 2018

Research offers new hope for healing wounds in patients with diabetes

One of the most frustrating and debilitating complications of diabetes is the development of wounds on the foot or lower leg. Once they form, they can persist for months, leading to painful and dangerous infections.

23 Apr 2018

Environmental pollutants found to worsen rheumatoid arthritis

Scientists have uncovered a link between the risk of developing rheumatoid arthritis and environmental pollutants, such as cigarette smoke.

19 Apr 2018

UT Southwestern scientists discover protein linked to metastatic breast cancer

Researchers at UT Southwestern Medical Center have identified a protein that is strongly associated with metastatic breast cancer and that could be a target for future therapies.

18 Apr 2018

Researchers generate stable cartilage tissue from adult mesenchymal stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

16 Apr 2018

Engineered immune cells clear deadly pediatric brain tumor in mice

Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated.

16 Apr 2018

Novel disease model for ALS and MS can be used to develop new immunotherapies

Researchers at Karolinska Institutet in Sweden have developed a new disease model for neurodegenerative diseases such as ALS and MS that can be used to develop new immunotherapies. The model is described in a publication in the scientific journal Nature Immunology.

16 Apr 2018

Deficiency of innate immune adaptor TRIF shortens survival time of ALS mice

Amyotrophic lateral sclerosis is a neurodegenerative disease damaging motor neurons in brain and spinal cords. ALS patients show progressive muscle weakness and atrophy, leading to a fatal respiratory muscle paralysis. There are no effective therapies for ALS.

16 Apr 2018

Artificial antimicrobial peptides may help fight against drug-resistant bacteria

During the past several years, many strains of bacteria have become resistant to existing antibiotics, and very few new drugs have been added to the antibiotic arsenal.

16 Apr 2018

Receptor that detects heat of red chili pepper may help protect the brain after TBI

A receptor on our immune cells that can detect both the heat of a red chili pepper and the extreme physical heat of a pizza oven may help protect the brain following a traumatic brain injury, scientists say.

13 Apr 2018

Versatile mouse model opens doors to new targeted cancer therapies

Researchers from the Seve Ballesteros Foundation-CNIO Brain Tumour Group at the Spanish National Cancer Research Centre have developed an extremely powerful and versatile mouse model that will improve cancer research and accelerate pre-clinical testing of novel targeted therapies. Their work appears in Nature Communications.

13 Apr 2018

Research reveals immune suppressive role of soluble antibodies in tumor progression

Wistar researchers have found that soluble antibodies promote tumor progression by inducing accumulation of myeloid-derived suppressor cells (MDSCs) in pre-clinical cancer models. Results were published online in Cancer Immunology Research.

13 Apr 2018

KU Cancer Center to present evidence supporting anti-cancer drug at AACR 2018

The University of Kansas Cancer Center will present preclinical evidence supporting Ciclopirox Prodrug (CPX-POM), an anti-cancer agent currently in Phase I clinical trials, at the American Association for Cancer Research 2018 Annual Meeting in Chicago. Ciclopirox Prodrug was discovered by researchers at The University of Kansas Cancer Center and KU's Institute for Advancing Medical Innovation.

12 Apr 2018

Transcription factor Sp7 found to play key role in tooth development

Amjad Javed, Ph.D., and University of Alabama at Birmingham colleagues have found a key role in tooth development for the transcription factor Specificity protein 7, or Sp7.

11 Apr 2018

Researchers discover how intestinal bacteria can influence blood glucose and lipid concentrations

Intestinal bacteria have attracted recent attention since they were discovered to influence various physiological functions and diseases in humans.

10 Apr 2018

Families support groundbreaking research on Charcot-Marie-Tooth disease

Lorena Martin's twin daughters kick butt on the soccer field. Martin is proud of how they hold their own, despite having a rare genetic disease called Charcot-Marie-Tooth (CMT), which has damaged their peripheral nervous system. The girls lack proper control of their hands and feet because their nerves can't send signals properly, so they play using power wheelchairs.

9 Apr 2018

Study reveals how apoE4 gene confers risk for Alzheimer's disease in brain cells

Using human brain cells, scientists at the Gladstone Institutes discovered the cause of--and a potential solution for--the primary genetic risk factor for Alzheimer's disease, a gene called apoE4.

9 Apr 2018

Mice study reveals important role of pTreg cell population in autoimmune diabetes

In autoimmune diseases such as type 1 diabetes, some of the immune system's T cells mistakenly attack the body's own cells, while protective T regulatory cells try to defend against that attack.

6 Apr 2018

Discordance between brain regions could lead to attention deficit disorders

Researchers from Case Western Reserve University School of Medicine and colleagues have discovered how two brain regions work together to maintain attention, and how discordance between the regions could lead to attention deficit disorders, including schizophrenia, bipolar disorder, and major depression.

6 Apr 2018