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Study sheds light on neuronal responses in ALS

In a recent study, scientists have linked changes in the size of motor neurons to the onset of symptoms in motor neurone disease (ALS).

5 Mar 2018

Researchers gain better understanding of anatomically distinct microcircuit brain networks

Roberto Fernández Galán, an assistant professor of electrical engineering and computer science at the university's School of Engineering, and a team of undergraduate researchers at Case Western Reserve have been recording the electrical activity of hundreds of neurons as they fire inside the brain of a mouse model-for up to half an hour at a time.

1 Mar 2018

CRISPR-like gene editing could be potential way to treat patients with harmful blood lipid levels

Using a variation of CRISPR gene editing may be a potential strategy for mimicking the protective effects of a genetic mutation linked to lower cholesterol levels and heart disease risks, according to new mouse research from the Perelman School of Medicine at the University of Pennsylvania published this week in Circulation.

28 Feb 2018

Penn study sheds new light on immune cell identity

Almost all cells in the human body have identical DNA sequences, yet there are 200-plus cell types with different sizes, shapes, and chemical compositions. Determining what parts of the genome are read to make protein and which are silenced is orchestrated by proteins called transcription factors.

21 Feb 2018

Study finds novel therapeutic strategy that preserves neuromuscular synapses in ALS mouse model

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, causes lethal respiratory paralysis within several years of diagnosis. There are no effective treatments to slow or halt this devastating disease.

21 Feb 2018

Bioactive compound limits collateral damage in the kidneys after heart attack

A heart attack triggers an acute inflammatory response at the damaged portion of the heart's left ventricle. If this acute inflammation lingers, it can lead to stretching of the ventricle and heart failure. The inflammation can claim another victim -- the kidneys.

21 Feb 2018

Lab-grown cerebellar cells may help explain how ASD develops at molecular level

Increasing evidence has linked autism spectrum disorder with dysfunction of the brain's cerebellum, but the details have been unclear. In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex, a genetic syndrome that often includes ASD-like features.

19 Feb 2018

Texas Biomed and The Children’s Hospital of San Antonio join forces to cure mysterious condition

Texas Biomedical Research Institute and The Children's Hospital of San Antonio have joined forces to cure a mysterious condition called Kawasaki disease.

15 Feb 2018

Cervical tumors may be vulnerable to therapies that attack cancer's fuel supply, study shows

Cancer therapies have improved -- in some cases dramatically -- over the past two decades, but treatment for cervical cancer has remained largely unchanged. All patients receive radiation and chemotherapy, yet despite the aggressive approach, the regimen fails in about one-third of patients with cervical cancer that has spread beyond the cervix but not outside the pelvis.

15 Feb 2018

Scientists program nanorobots to shrink tumors

In a major advancement in nanomedicine, Arizona State University scientists, in collaboration with researchers from the National Center for Nanoscience and Technology, of the Chinese Academy of Sciences, have successfully programmed nanorobots to shrink tumors by cutting off their blood supply.

12 Feb 2018

Cholesterol and other lipids in the blood play role in many diseases

Lipids are fatty molecules that play important signaling and storage roles in the body, but having an excess of some lipids, like cholesterol, is a risk factor for many metabolic diseases.

8 Feb 2018

HDAC6 inhibition could be promising therapeutic approach for peripheral neuropathies

Inhibiting HDAC6 improves the structural stability of cells and protects against neuronal damage. Leuven research uncovered that targeting this mechanism could be a promising therapeutic approach for peripheral neuropathies, whether due to Charcot-Marie-Tooth disease (CMT) or as a side effect of chemotherapy.

8 Feb 2018

Mitochondrial DNA may play more important role in metastatic cancer than previously thought

DNA found in the mitochondria may play a more significant role in metastatic cancer than originally thought.

6 Feb 2018

Compounds derived from hops may improve cognitive, other functions in metabolic syndrome patients

A group of compounds derived from hops can likely improve cognitive and other functions in people with metabolic syndrome, new research at Oregon State University and Oregon Health & Science University suggests.

5 Feb 2018

Novel grape-derived compounds could be developed as therapeutic agents for treatment of depression

In a study to be published online February 2 in Nature Communications, scientists from the Icahn School of Medicine at Mount Sinai describe an extensive analysis of novel grape-derived compounds, dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc),which might be developed as therapeutic agents for the treatment of depression.

2 Feb 2018

Researchers move closer to solving puzzle of 15q13.3 microdeletion syndrome

Researchers are closer to solving the puzzle of a complex neurological condition called 15q13.3 microdeletion syndrome. Individuals with this condition are missing a small piece of chromosome 15 that usually contains six genes, but which one of the genes is responsible for the clinical characteristics of patients has not been clear.

2 Feb 2018

Researchers identify cause of severe genetic disease

Mutations in the p63 protein lead to a number of disorders, but none is as severe as the AEC syndrome. Scientists at Goethe University Frankfurt in collaboration with a research group from the University of Naples Federico II have now discovered that this syndrome resembles diseases such as Alzheimer's, Parkinson's or ALS more closely than it does other p63-based syndromes.

2 Feb 2018

Two bacterial species collaborate to drive development of colon cancers

Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer, a study led by a Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy research team finds.

1 Feb 2018

Researchers use gene therapy that lengthens telomeres to cure pulmonary fibrosis in mice

Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, currently lacking effective treatment.

30 Jan 2018

Researchers reverse symptoms associated with Rett syndrome in mouse model

It is a parent's nightmare: a child is born apparently healthy, then stops meeting developmental milestones at one year old. Her verbal and motor skills vanish, and irregular breathing, seizures, and a host of other problems appear.

29 Jan 2018

Mouse Model News and Research

Study sheds light on neuronal responses in ALS

Researchers gain better understanding of anatomically distinct microcircuit brain networks

CRISPR-like gene editing could be potential way to treat patients with harmful blood lipid levels

Penn study sheds new light on immune cell identity

Study finds novel therapeutic strategy that preserves neuromuscular synapses in ALS mouse model

Bioactive compound limits collateral damage in the kidneys after heart attack

Lab-grown cerebellar cells may help explain how ASD develops at molecular level

Texas Biomed and The Children’s Hospital of San Antonio join forces to cure mysterious condition

Cervical tumors may be vulnerable to therapies that attack cancer's fuel supply, study shows

Scientists program nanorobots to shrink tumors

Cholesterol and other lipids in the blood play role in many diseases

HDAC6 inhibition could be promising therapeutic approach for peripheral neuropathies

Mitochondrial DNA may play more important role in metastatic cancer than previously thought

Compounds derived from hops may improve cognitive, other functions in metabolic syndrome patients

Novel grape-derived compounds could be developed as therapeutic agents for treatment of depression

Researchers move closer to solving puzzle of 15q13.3 microdeletion syndrome

Researchers identify cause of severe genetic disease

Two bacterial species collaborate to drive development of colon cancers

Researchers use gene therapy that lengthens telomeres to cure pulmonary fibrosis in mice

Researchers reverse symptoms associated with Rett syndrome in mouse model

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