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SLITRK1 gene appears to contribute to some cases of Tourette's Syndrome

In what may be a major milestone in Tourette's Syndrome (TS) research, scientists at Yale School of Medicine and their colleagues have identified a gene called SLITRK1 that appears to contribute to some cases of TS, according to a report in the October 14 issue of Science.

13 Oct 2005

Chromosomes in the nucleus of the cell carry the material of heredity, or genes

Abnormal cell division that yields cells with an extra set of chromosomes can initiate the development of tumors in mice, researchers at Dana-Farber Cancer Institute have shown, validating a controversial theory about cancer causation put forth by a scientific visionary nearly 100 years ago.

12 Oct 2005

Personalized medicine to improve the outcome for breast cancer patients

As cancer remains a leading cause of death in the United States, early detection and treatment are critical keys to improving the survival rate. Yet, an individual's response to treatment varies considerably, even among cancers of the same histological type.

12 Oct 2005

Biologists uncover pivotal role of a gene called "Cut"

A DNA-binding protein, Cut interprets and transcribes the developmental signals sent through the "Notch" gene, which regulates a layer of epithelial cells as they replicate and divide. But when Cut garbles those signals the result is uncontrolled cell proliferation, sometimes with dire genetic and health consequences.

12 Oct 2005

Why the human immune system does not function well in the weightlessness of space

Researchers at the San Francisco VA Medical Center have identified a set of key immune-response genes that do not turn on in a weightless environment. The discovery is another clue in the effort to solve an almost 40-year-old mystery

12 Oct 2005

Novel therapies for pleural mesothelioma

Researchers at New York University School of Medicine and Wayne State University have found a molecule that reveals the early stages of pleural mesothelioma, a chest cancer caused by asbestos. The finding opens the way to a blood test for the disease, according to a new study published in the Oct. 13 issue of The New England Journal of Medicine.

12 Oct 2005

Obesity associated with a threefold increase in SCD1 expression in obese muscle

The gene encoding an enzyme that hinders muscle from burning fat manufactures three times more enzyme in the muscle of obese people than lean people, researchers from Duke University Medical Center and Louisiana State University have found. This causes the obese muscle tissue to both store more fat and burn less fat, the researchers said.

11 Oct 2005

Sleletal muscle findings highlight the importance of exercise in obese people

The findings suggest that muscle bears a metabolic memory of obesity, which may help to explain why sustained weight loss can be difficult despite cutting calories, according to the researchers. Exercise might more successfully override the aberrant metabolic program in muscle, they suggest, thereby improving the long-term prognosis of those prone to obesity.

11 Oct 2005

Experimental HIV vaccine progresses in trials

A novel vaccine targeted to multiple HIV subtypes found worldwide has moved into the second phase of clinical testing, the National Institute of Allergy and Infectious Diseases (NIAID) announced today.

11 Oct 2005

Aging may intensify and prolong feeling run down when common infections like the flu occur

A new study, done with mice and published in the Federation of the American Societies of Experimental Biology Journal, suggests that miscommunication between the immune system and brain may be to blame for extended sickness symptoms and other cognitive disorders in elderly people and animals with an infection.

11 Oct 2005

Bats carry SARS like virus

An international consortium headed by CAS researchers has identified that the Chinese horseshoe bat is healthy carriers of a virus that is very closely related to those causing SARS (severe acute respiratory syndrome).

10 Oct 2005

New treatments for health conditions related to abnormal iron metabolism

A new study conducted by scientists at Children's Hospital Oakland Research Institute could help researchers develop new treatments for a variety of health conditions that are all related to abnormal iron metabolism. More than one million Americans have abnormal iron levels in their bodies.

10 Oct 2005

Technique for inserting genes into specific sites on the genome in liver cells

The genes are inserted into non-coding regions of the genome so there is no danger of interfering with the functioning of other genes. Once inserted, the gene remains a permanent part of the cell's genome.

10 Oct 2005

Important milestone towards more individually targeted and effective treatments for cancer patients

The research team has now identified crucial genes in a range of common cancers that have been reported to predict a patient's response to treatment. This follows the team's earlier success in studying a tumor suppressor gene associated with acute lymphoblastic leukaemia (ALL) in children.

9 Oct 2005

Researchers find gene that is important for the control of fundamental rhythms in nematode worms

University of Utah biologists found a gene that controls rhythmic events in a worm's life: swallowing food, laying eggs and pooping.

9 Oct 2005

Researchers find CCL5 protein produced in the course of respiratory viral infections can serve to protect macrophages from an untimely death

Enlisted to help fight viral infections, immune cells called macrophages consume virus-infected cells to stop the spread of the disease in the body.

9 Oct 2005

Discovery of new features of a key quality-control mechanism in our cells

Mutations in genes are the basis of evolution, so we owe our existence to them. Most mutations are harmful, however, because they cause cells to build defective proteins. So cells have evolved quality control mechanisms that recognize and counteract genetic mistakes.

9 Oct 2005

Specific gene on chromosome 15 regulates inflammation

A team of international researchers has discovered that a specific gene on chromosome 15 regulates inflammation, a finding with implications for a wide range of disorders, including cancer, cardiovascular disease, diabetes, obesity, Alzheimer's, and infections. The findings are published in the October 9 online issue of Nature Genetics.

9 Oct 2005

New information regarding the genetic, cellular and neurological bases of susceptibility to autism and schizophrenia

Two New Jersey research teams are reporting discoveries about the biological nature of psychiatric disorders that may bring them closer to the ultimate goal of finding cures for complex diseases, such as autism and schizophrenia.

9 Oct 2005

Particular versions of the TGFb1 gene are largely responsible for how badly the illness affects patients' lungs

Subtle differences in other genes -- besides the defective gene known to cause the illness cystic fibrosis -- can significantly modify the inherited disease's severity, a large new multi-center national study has concluded.

5 Oct 2005