Genes News and Research

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Fruit fly discovery could lead to a completely new approach to tackling some cancers

Scientists studying the humble fruit fly have found a family of proteins that enhances the sensitivity of a cell to a hormone that can trigger abnormal growth and cancer. Their discovery could lead to a completely new approach to tackling some cancers and the development of new drugs to stop uncontrolled growth in a wide variety of tumour cells.

28 Sep 2005

Common form of thalassaemia can be managed without blood transfusion

Haemoglobin E â thalassaemia - the commonest form of severe thalassaemia in many Asian countries - can be managed without transfusion in many patients, suggests a research letter published online today (Thursday September 29, 2005) by The Lancet.

28 Sep 2005

The immune mechanisms of atherosclerosis

Scientists are depicting a novel scheme for atherosclerosis development, suggesting that this pathology might result from an imbalance between pro-inflammatory processes and calming ones.

28 Sep 2005

Survival of heart attack patients placed on beta-blocker therapy corresponds to specific variations in their genes

Survival of heart attack and unstable angina patients placed on beta-blocker therapy corresponds to specific variations in their genes, according to a study by researchers at Washington University School of Medicine in St. Louis and the Mid America Heart Institute in Kansas City.

27 Sep 2005

Fndings could lead to a treatment for idiopathic interstitial pneumonia

An incurable, deadly lung disorder, "idiopathic interstitial pneumonia" (IIP), whose causes were mysterious arises from a combination of a genetic predisposition and damage due to inhaled chemicals, notably from cigarette smoking, Duke University Medical Center researchers have found.

27 Sep 2005

Gene variants and beta-blockers associated with increased risk of death

Patients with certain gene variants who were prescribed beta-blocker drugs after acute coronary syndrome (ACS) had an increased risk of death over the next three years, according to a study in the September 28 issue of Journal of the American Medical Association (JAMA).

27 Sep 2005

New virus-based gene therapy delivery system to help fight cancer

A Mayo Clinic research team has devised a new virus-based gene therapy delivery system to help fight cancer. Researchers say their findings will help overcome hurdles that have hindered gene therapy cancer treatments.

27 Sep 2005

Possibility of tailored treatments for addiction based on how a person's genes behave

Scientists have learned how a genetic variation long suspected in making some people susceptible to alcoholism and narcotic drug addiction actually does so.

27 Sep 2005

Temperature can regulate the circadian clock in zebrafish

The biological clock controls the circadian rhythms of a wide range of physiological and behavioral processes, from fluctuating hormone levels to sleep - wake cycles and feeding patterns.

27 Sep 2005

Pursuit of potential drugs and small molecules that target the IGF-1 receptor

Pharmaceutical companies around the world still come knocking on Renato Baserga, M.D.,'s door. And for good reason.

27 Sep 2005

Computer program helps explain how the same proteins can play different roles in a wide range of cellular processes

University of California, San Diego biochemists have developed a computer program that helps explain a long-standing mystery: how the same proteins can play different roles in a wide range of cellular processes, including those leading to immune responses and cancer.

27 Sep 2005

Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors

...a discovery that could pave the way for more effective cancer treatments.

27 Sep 2005

Nature may play a larger role than nurture when it comes to family relationships

Researchers from the University of Texas at Austin and George Washington University in Washington, D.C., used data on 674 families, each with a same-sex adolescent pair, to evaluate the factors that made up the relationships and individual personalities.

26 Sep 2005

Plans to develop a "universal beta-cell line" - treatment for type 1 diabetes

Transplantation of insulin-producing pancreatic beta-cells shows great promise as a treatment for type 1 diabetes, but development of this therapy has been hampered by a severe shortage of donor beta-cells, which are obtained from decreased human donors.

26 Sep 2005

Testing for drug resistance in HIV-infected patients at the time of diagnosis may increase patients' life expectancy

Resistance to antiretroviral therapy, even in patients who have never received treatment, is a growing concern. However, genotype resistance testing, which involves looking for the presence of resistance genes, is not a standard procedure at the time a patient is diagnosed with HIV, probably due to lack of data on its benefits and its relatively high cost compared with other routine blood tests.

26 Sep 2005

Extreme gene pin-pointed

One teenager likes to snowboard off a cliff. Another prefers to read a book and wouldn't think of trading places. Why these differences exist is a mystery, but for the first time researchers have identified a possible genetic explanation behind risk-seeking behavior.

26 Sep 2005

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Scientists from J. Craig Venter Institute, Ludwig Institute for Cancer Research, and The Johns Hopkins University School of Medicine identified three novel mutations in two receptor tyrosine kinases in glioblastoma tumors using high throughput sequencing.

26 Sep 2005

Increasingly virulent Staph infections

In a "Brief Report" in the 22 September 2005 issue of the New England Journal of Medicine, researchers at the University of Chicago describe three cases of rapidly progressive and ultimately fatal Staphylococcus aureus infections in small children.

26 Sep 2005

Researchers map genetic location that explains why certain blood pressure-lowering drugs aren't effective for some people

"The findings bring us a step closer to developing targeted therapies for patients with high blood pressure who might otherwise be started on medications that won't help," said lead author Sandosh Padmanabhan, Ph.D.

26 Sep 2005

Mutations in the gene, called PIG-A may help identify individuals at high risk for cancer

A new study to detect an elevated rate of mutations in a gene on the X chromosome holds promise for developing a test that could identify individuals at risk for developing cancer.

26 Sep 2005

Genes News and Research

Fruit fly discovery could lead to a completely new approach to tackling some cancers

Common form of thalassaemia can be managed without blood transfusion

The immune mechanisms of atherosclerosis

Survival of heart attack patients placed on beta-blocker therapy corresponds to specific variations in their genes

Fndings could lead to a treatment for idiopathic interstitial pneumonia

Gene variants and beta-blockers associated with increased risk of death

New virus-based gene therapy delivery system to help fight cancer

Possibility of tailored treatments for addiction based on how a person's genes behave

Temperature can regulate the circadian clock in zebrafish

Pursuit of potential drugs and small molecules that target the IGF-1 receptor

Computer program helps explain how the same proteins can play different roles in a wide range of cellular processes

Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors

Nature may play a larger role than nurture when it comes to family relationships

Plans to develop a "universal beta-cell line" - treatment for type 1 diabetes

Testing for drug resistance in HIV-infected patients at the time of diagnosis may increase patients' life expectancy

Extreme gene pin-pointed

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Increasingly virulent Staph infections

Researchers map genetic location that explains why certain blood pressure-lowering drugs aren't effective for some people

Mutations in the gene, called PIG-A may help identify individuals at high risk for cancer

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