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Gene networks may offer attractive targets for developing new autism drugs

A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism.

6 Jun 2014

U.S. Preventive Services Task Force recommends hepatitis B screening for high risk individuals

A simple blood test can detect if a person is one of the two billion people worldwide infected with hepatitis B. And now the U.S. Preventive Services Task Force recommends that all teens and adults who are high risk for hepatitis B get screened for the infection.

6 Jun 2014

Regeneration of a chronically diseased liver may be possible, say Harvard researchers

Harvard Stem Cell Institute scientists at Boston Children's Hospital have new evidence in mice that it may be possible to repair a chronically diseased liver by forcing mature liver cells to revert back to a stem cell-like state.

6 Jun 2014

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

St. Jude Children's Research Hospital scientists have identified problems in a connection between brain structures that may predispose individuals to hearing the "voices" that are a common symptom of schizophrenia. The work appears in the June 6 issue of the journal Science.

6 Jun 2014

Scientists identify new way to reactivate latent HIV

A team of scientists at the Gladstone Institutes has identified a new way to make latent HIV reveal itself, which could help overcome one of the biggest obstacles to finding a cure for HIV infection.

6 Jun 2014

United Spinal Association, NSCIA to convene at ROCH to address disability issues

United Spinal Association and advocates from its membership division, National Spinal Cord Injury Association (NSCIA), will gather in Washington, D.C. on June 22-25 for Roll on Capitol Hill to shape policies that impact the health, independence and quality of life of people living with spinal cord injuries and disorders (SCI/D).

6 Jun 2014

New targets found for potential intervention in breast cancer

Scientists from the Florida campus of The Scripps Research Institute have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments.

6 Jun 2014

Rice, MD Anderson researchers refine technique for attacking hard-to-reach tumors

Short, customized carbon nanotubes have the potential to deliver drugs to pancreatic cancer cells and destroy them from within, according to researchers at Rice University and the University of Texas MD Anderson Cancer Center.

6 Jun 2014

Improved glycemic control can slow progression of ESRD in type 1 diabetic people

People with type 1 diabetes who have developed kidney complications can slow the progression of their complications by improving control of their glycemic (blood glucose) levels over the long term.

6 Jun 2014

SGC and CHDI Foundation collaborate to discover new drug targets for Huntington's disease

The Structural Genomics Consortium (SGC) and CHDI Foundation have entered into a unique open-access research collaboration to discover and characterize new drug targets for Huntington's disease (HD) using structural and chemical biology In this first partnership of its kind, SGC and CHDI have explicitly agreed not to file for patents on any of the collaborative research and to make all reagents and knowledge available without restriction to the wider research community, including pharmaceutical, biotech, and academic research groups.

6 Jun 2014

Researchers find that protein serves as on-off switch for "beigeing" of fat

Scientists this week reported that a molecular pathway called mTORC1 controls the conversion of unhealthy white fat into beige fat, an appealing target for increasing energy expenditure and reducing obesity.

6 Jun 2014

Device used in physics and chemistry reveals dynamics of pervasive pathogen

If you have it, you probably don't know it. Cytomegalovirus, or CMV, is perhaps one of the biggest pathogens you've never heard of-big, both proportionately and epidemiologically.

6 Jun 2014

Ocugen's OCU100 gets FDA orphan drug designation for treatment of retinitis pigmentosa

Ocugen, Inc. and the University of Colorado today announced exclusive license agreements that allow for Ocugen to continue developing two drug candidates for the treatment for ophthalmology indications, and that one of the assets, OCU100, recombinant lens epithelium derived growth factor 1-326 (LEDGF1-326), received orphan-drug status from the U.S. Food and Drug Administration for treatment of retinitis pigmentosa (RP), a rare eye disease.

6 Jun 2014

Merck enrolls first patient in reformulated raltegravir Phase 3 trial for treatment of HIV-1 infection

Merck, known as MSD outside the United States and Canada, today announced that the first patient has been enrolled in the company's global Phase 3 clinical trial, ONCEMRK.

6 Jun 2014

Canadian invasive pneumococcal disease outbreak characterised

Canadian scientists have reported details of an outbreak of serotype 12F invasive pneumococcal disease that occurred in Winnipeg between 2009 and 2011 and predominantly affected people who were homeless and/or engaged in illegal drug use.

5 Jun 2014

Glycaemic control crucial in first years after diabetes diagnosis

The largest deterioration in glycaemic control among patients with newly diagnosed Type 2 diabetes occurs in the first 2 years after diagnosis, research shows.

5 Jun 2014

Patients and families benefit from shorter TB treatment regimens

Shorter TB treatment regimens will reduce the out-of-pocket expenses incurred by both patients and their family members, who often act as the patients' guardians. In addition, shorter TB regimens may allow an earlier return to productive activities for patients and their families.

5 Jun 2014

Many heroin users transitioned from prescription opioids, finds study

A research paper published in the May 28, 2014 issue of JAMA Psychiatry a paper entitled "The Changing Face of Heroin Use in the United States A Retrospective Analysis of the Past 50 Years" concluded that heroin abuse has left low-income urban areas and has become prevalent in more affluent suburbs and rural areas with mostly white populations.

5 Jun 2014

$SAGE reports preliminary data from SAGE-547 Phase 1/2 clinical trial for super-refractory status epilepticus$

SAGE reports preliminary data from SAGE-547 Phase 1/2 clinical trial for super-refractory status epilepticus

SAGE Therapeutics, a biopharmaceutical company developing novel medicines to treat life-threatening, rare central nervous system (CNS) disorders, today announced preliminary data from its ongoing open-label Phase 1/2 clinical trial of SAGE-547, an allosteric modulator of GABAA receptors, in patients with super-refractory status epilepticus (SRSE).

5 Jun 2014

RPB grants $500,000 to accelerate treatments for Retinitis Pigmentosa

Research to Prevent Blindness (RPB), the leading eye research foundation, is providing $500,000 to accelerate the development of treatments for Retinitis Pigmentosa (RP) -- a family of retinal diseases that progressively create extreme tunnel vision, loss of night vision and leave affected patients legally blind by the age of 40.

5 Jun 2014

Drugs News and Research

Gene networks may offer attractive targets for developing new autism drugs

U.S. Preventive Services Task Force recommends hepatitis B screening for high risk individuals

Regeneration of a chronically diseased liver may be possible, say Harvard researchers

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

Scientists identify new way to reactivate latent HIV

United Spinal Association, NSCIA to convene at ROCH to address disability issues

New targets found for potential intervention in breast cancer

Rice, MD Anderson researchers refine technique for attacking hard-to-reach tumors

Improved glycemic control can slow progression of ESRD in type 1 diabetic people

SGC and CHDI Foundation collaborate to discover new drug targets for Huntington's disease

Researchers find that protein serves as on-off switch for "beigeing" of fat

Device used in physics and chemistry reveals dynamics of pervasive pathogen

Ocugen's OCU100 gets FDA orphan drug designation for treatment of retinitis pigmentosa

Merck enrolls first patient in reformulated raltegravir Phase 3 trial for treatment of HIV-1 infection

Canadian invasive pneumococcal disease outbreak characterised

Glycaemic control crucial in first years after diabetes diagnosis

Patients and families benefit from shorter TB treatment regimens

Many heroin users transitioned from prescription opioids, finds study

SAGE reports preliminary data from SAGE-547 Phase 1/2 clinical trial for super-refractory status epilepticus

RPB grants $500,000 to accelerate treatments for Retinitis Pigmentosa

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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