Genes News and Research

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Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence

Using a recently developed mouse model of breast cancer, a team from the University of Pennsylvania School of Medicine has shown that Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence.

20 Sep 2005

Study points to importance of MYC gene in cancer progression

The cancer gene MYC is among the most commonly overexpressed oncogenes in human cancers. Most human cancers demonstrate high levels of MYC or its biological partners, including those of the breast, ovaries, lung, prostate, and skin, as well as leukemias and lymphomas.

19 Sep 2005

First large-scale whole genome map of genetic variability associated with Parkinson's disease

Mayo Clinic researchers in collaboration with scientists at Perlegen Sciences, Inc. and funded by the Michael J. Fox Foundation for Parkinson's Research have produced the first large-scale whole genome map of genetic variability associated with Parkinson's disease.

19 Sep 2005

New research will play a major role in improving the future of breast cancer treatment

Cancer specialists at University of East Anglia have discovered that several 'ADAMTS' genes are turned off in breast cancer compared to normal breast tissue, while others are switched on. These genes could be targets for the development of 'smart' drugs tailored to treat individual patients' tumours.

19 Sep 2005

Molecular pathway in mice that makes prostate cells vulnerable to cancer-causing oxygen damage

Scientists from Maryland and New Jersey have identified a molecular pathway in mice that makes prostate cells vulnerable to cancer-causing oxygen damage.

19 Sep 2005

First-of-its-kind test on a microchip array will help diagnose retinitis pigmentosa

Rapid genetic testing for eye disease is becoming a reality, thanks to a technology developed at the University of Michigan Kellogg Eye Center.

19 Sep 2005

Manic depression linked to two chromosomal regions in the human genome

An international team of 53 researchers has offered the most convincing evidence so far linking bipolar disorder, also known as manic depression, to two chromosomal regions in the human genome. The finding gives scientists refined targets for further gene studies.

19 Sep 2005

New and unusual class of genes plays an important role in the development of chronic lymphocytic leukemia

The study found that the loss of two genes for producing small molecules known as microRNAs enables damaged cells to survive, rather than normally self-destructing before they become cancerous.

12 Sep 2005

RNAi therapeutic successful for treatment of SARS respiratory virus in Rhesus Macaque

Intradigm Corporation announced today its collaboration with Chinese academic and biotech groups has achieved clear evidence of prophylactic and therapeutic effects of siRNA (small interfering RNA) agents in Rhesus monkey to treat SARS coronavirus (SCV) respiratory infection.

12 Sep 2005

Discovery of mechanism linking color vision and cancer genes

Biologists at New York University have discovered a system by which a random choice between two distinct cellular fates in the fruit fly eye becomes firmly established.

12 Sep 2005

Nuclear receptor proteins could change anti-inflammatory treatments

Several nuclear receptor proteins appear to overlap in their ability to exert anti-inflammatory effects, according to new research by scientists at the University of California, San Diego (UCSD).

12 Sep 2005

HOXA1 is a gene that's been looking for a disorder for a long time

Researchers at Children's Hospital Boston, who specialize in studying the genetics of rare eye-movement disorders, have found a rare genetic syndrome whose implications go far beyond the eye, raising intriguing questions about human cardiovascular and brain development.

12 Sep 2005

Key cellular switch that controls glucose production in liver cells

In many patients with type 2 diabetes, the liver acts like a sugar factory on overtime, churning out glucose throughout the day, even when blood sugar levels are high. Scientists at the Salk Institute for Biological Studies discovered a key cellular switch that controls glucose production in liver cells.

12 Sep 2005

Workshop - stem cells in reproduction and in the brain

"Once we have found the factors by which body cells can be re-programmed into stem cells, then therapeutic cloning might become superfluous," said Hans R. Scholer, director of the Max Planck Institute for Molecular Biomedicine in Munster, Germany, at an international scientific symposium on stem cell research in Kobe, Japan.

10 Sep 2005

Human brain still evolving, who knows what the future has to offer!

According to a team of University of Chicago scientists they have found strong evidence that the human brain is still evolving.

10 Sep 2005

Animal model of Parkinson's disease reveals striking sensitivity to common environmental toxins

In findings that support a relationship between agricultural chemicals and Parkinson's disease, two groups of researchers have found new evidence that loss of DJ-1, a gene known to be linked to inherited Parkinson's disease, leads to striking sensitivity to the herbicide paraquat and the insecticide rotenone.

7 Sep 2005

Testing for specific breast cancer genes unadvisable if no family history of disease exists

According to the Preventive Services Task Force in the U.S., routine testing for mutations in the BRCA1 and BRCA2 genes, which have been linked to breast and ovarian cancer, are not advised unless women have a family history of the disease.

7 Sep 2005

Diet rich in soy protein may alleviate fatty liver

A group of researchers from Mexico has discovered that a diet rich in soy protein may alleviate fatty liver, a disease which often accompanies diabetes. The details of their findings appear in the September issue of the Journal of Lipid Research, an American Society for Biochemistry and Molecular Biology journal.

6 Sep 2005

British Heart Foundation gene research helped by thousands of brothers and sisters

An unusual British Heart Foundation (BHF) 'DNA database' from brothers and sisters across the UK has enabled researchers to pinpoint six genetic 'hotspots' that can double the risk of developing early heart disease.

6 Sep 2005

Human embryonic stem cell lines accumulate changes in their genetic material over time

The findings do not limit the utility of the cells for some types of research or for some future clinical applications, the researchers say, but draw attention to the need to closely monitor stem cell lines for genetic changes and to study how these alterations affect the cells' behavior.

6 Sep 2005

Genes News and Research

Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence

Study points to importance of MYC gene in cancer progression

First large-scale whole genome map of genetic variability associated with Parkinson's disease

New research will play a major role in improving the future of breast cancer treatment

Molecular pathway in mice that makes prostate cells vulnerable to cancer-causing oxygen damage

First-of-its-kind test on a microchip array will help diagnose retinitis pigmentosa

Manic depression linked to two chromosomal regions in the human genome

New and unusual class of genes plays an important role in the development of chronic lymphocytic leukemia

RNAi therapeutic successful for treatment of SARS respiratory virus in Rhesus Macaque

Discovery of mechanism linking color vision and cancer genes

Nuclear receptor proteins could change anti-inflammatory treatments

HOXA1 is a gene that's been looking for a disorder for a long time

Key cellular switch that controls glucose production in liver cells

Workshop - stem cells in reproduction and in the brain

Human brain still evolving, who knows what the future has to offer!

Animal model of Parkinson's disease reveals striking sensitivity to common environmental toxins

Testing for specific breast cancer genes unadvisable if no family history of disease exists

Diet rich in soy protein may alleviate fatty liver

British Heart Foundation gene research helped by thousands of brothers and sisters

Human embryonic stem cell lines accumulate changes in their genetic material over time

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