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New CRISPR-EZ method makes genome editing much easier in mice

University of California, Berkeley scientists have developed a quicker and more efficient method to alter the genes of mice with CRISPR-Cas9, simplifying a procedure growing in popularity because of the ease of using the new gene-editing tool.

28 May 2016

Certain HLA genes may increase ovarian cancer risk in women

Researchers in the Center for Immunotherapy at Roswell Park Cancer Institute have evaluated the human leukocyte antigen (HLA), a group of genes that help regulate the body's immune system, for underlying differences in ovarian cancer patients' response to therapy.

28 May 2016

New player in calcium signalling pathways acts as molecular brake to Orai activation

Information flow in cells relies on calcium as a key agent in several signalling pathways. Calcium dependent signalling is crucial in nearly every aspect of life - muscle movement, immune reactions, nerve function, light sensing and many such processes.

28 May 2016

Study identifies potential new treatment for subset of gastric cancer patients

Testing cancers for 'addiction' to a gene that boosts cell growth can pick out patients who may respond to a targeted drug under development, a major new study reports.

28 May 2016

Increasing specific microRNA levels can restore chemotherapy sensitivity in pancreatic cancer cells

By increasing the level of a specific microRNA (miRNA) molecule, researchers have for the first time restored chemotherapy sensitivity in vitro to a line of human pancreatic cancer cells that had developed resistance to a common treatment drug.

27 May 2016

Study finds that TPC2 protein regulates melanin production

A year and a half ago, researchers at Brown University found a molecular gas pedal for melanin production. Now they've found a brake. For scientists, the finding deepens not only the basic understanding of how eyes, skin and hair gain color, but also what perhaps can be done in disorders, such as albinism, when that doesn't happen.

27 May 2016

New understanding of neurotransmitter transporter mechanism gives hope for treating depression, addicition

When nerve cells have to communicate with each other in our brains, it involves release of small signal molecules, the so-called neurotransmitters, which act as chemical messengers in specific points of contact between nerve cells, called synapses.

27 May 2016

Salk scientists discover REV-ERBα protein that controls strength of circadian rhythm

At noon every day, levels of genes and proteins throughout your body are drastically different than they are at midnight. Disruptions to this 24-hour cycle of physiological activity are why jet lag or a bad night's sleep can alter your appetite and sleep patterns for days--and even contribute to conditions like heart disease, sleep disorders and cancers.

27 May 2016

Research sheds light on how subtle genetic differences in DMD patients produce variation in symptoms

Johns Hopkins researchers report they have inadvertently found a way to make human muscle cells bearing genetic mutations from people with Duchenne muscular dystrophy (DMD).

27 May 2016

Novel way of directly activating Bak protein can trigger cell death

Melbourne researchers have discovered a new way of triggering cell death, in a finding that could lead to drugs to treat cancer and autoimmune disease.

27 May 2016

Smell or taste of food can shorten lifespan by affecting sensory neurons

Animals can perceive changes in many environmental factors such as temperature and the taste or smell of foods. This is achieved by specialized nerve cells called sensory neurons. Interestingly, sensory neurons have been known to control the rate of aging in various animals, including the tiny free living roundworm C. elegans.

27 May 2016

TSRI study shows how specific gene mutation promotes growth of aggressive tumors

Scientists at The Scripps Research Institute have caught a cancer-causing mutation in the act. A new study shows how a gene mutation found in several human cancers, including leukemia, gliomas and melanoma, promotes the growth of aggressive tumors.

27 May 2016

New hydrogel-based biochip may help in early diagnosis of bowel cancer

Researchers from the Moscow Institute of Physics and Technology, the Engelhardt Institute of Molecular Biology, the Institute of Bioorganic Chemistry and a number of other Russian research centers have developed a new method of diagnosing colorectal cancer.

27 May 2016

Early-life stress may lead to functional dyspepsia in adulthood

Traumatic events early in life can increase levels of norepinephrine—the primary hormone responsible for preparing the body to react to stressful situations—in the gut, increasing the risk of developing chronic indigestion and anxiety during adulthood, a new study in American Journal of Physiology—Gastrointestinal and Liver Physiology reports.

27 May 2016

UT Southwestern study offers more insight into cholesterol transporter

Using X-ray crystallography, UT Southwestern Medical Center researchers have determined the 3-D atomic structure of a human sterol transporter that helps maintain cholesterol balance.

27 May 2016

RBFOX2 dysregulation may cause heart damage in diabetic patients

Cardiac complications are the number one cause of death among diabetics. Now a team of scientists has uncovered a molecular mechanism involved in a common form of heart damage found in people with diabetes.

27 May 2016

Prepackaged food may contribute to more weight loss than self-selected diet

Increased portion sizes in Americans' diets is widely recognized as a contributor to the obesity epidemic, and now new research published in Obesity, the scientific journal of The Obesity Society, examines the effect of prepackaged, portion-controlled meals on weight loss.

26 May 2016

Gene mutation linked to autism plays key role in formation, maturation of synapses

A new study from MIT neuroscientists reveals that a gene mutation associated with autism plays a critical role in the formation and maturation of synapses -- the connections that allow neurons to communicate with each other.

26 May 2016

Malaria parasites use complement system to evade human immune response, study finds

The malaria parasite Plasmodium falciparum hijacks an immune system process to invade red blood cells, according to a study led by researchers at Penn State College of Medicine. Understanding how malaria invades the cells could lead to a more effective vaccine.

26 May 2016

Research sheds new light on biological processes underlying neurodegeneration in AD

Progranulin is a central protein in both neuronal survival and neurodegenerative diseases. It is thus not surprising that altered progranulin levels represent a universal theme shared across several common neurodegenerative diseases.

26 May 2016

G Protein News and Research

New CRISPR-EZ method makes genome editing much easier in mice

Certain HLA genes may increase ovarian cancer risk in women

New player in calcium signalling pathways acts as molecular brake to Orai activation

Study identifies potential new treatment for subset of gastric cancer patients

Increasing specific microRNA levels can restore chemotherapy sensitivity in pancreatic cancer cells

Study finds that TPC2 protein regulates melanin production

New understanding of neurotransmitter transporter mechanism gives hope for treating depression, addicition

Salk scientists discover REV-ERBα protein that controls strength of circadian rhythm

Research sheds light on how subtle genetic differences in DMD patients produce variation in symptoms

Novel way of directly activating Bak protein can trigger cell death

Smell or taste of food can shorten lifespan by affecting sensory neurons

TSRI study shows how specific gene mutation promotes growth of aggressive tumors

New hydrogel-based biochip may help in early diagnosis of bowel cancer

Early-life stress may lead to functional dyspepsia in adulthood

UT Southwestern study offers more insight into cholesterol transporter

RBFOX2 dysregulation may cause heart damage in diabetic patients

Prepackaged food may contribute to more weight loss than self-selected diet

Gene mutation linked to autism plays key role in formation, maturation of synapses

Malaria parasites use complement system to evade human immune response, study finds

Research sheds new light on biological processes underlying neurodegeneration in AD

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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