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Reduced activity of transcription factor plays key role in triggering pulmonary fibrosis

To date, the molecular basis of pulmonary fibrosis has been poorly understood. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of the disease.

26 Dec 2017

Researchers find more precise, neuroprotective approach to fix MS-damaged nerves

Gene expression in specific cells and in specific regions can provide a more precise, neuroprotective approach than traditional treatments for neurological diseases.

26 Dec 2017

T cell-inducing dengue vaccines could confer broader protection for kids born to vaccinated mothers

For a long time, a dengue vaccine was the holy grail in dengue research. Now that a dengue vaccine is finally on the market (Sanofi's Dengvaxia), other issues have arisen, such as what happens in the babies of vaccinated mothers.

22 Dec 2017

Scientists elucidate why exercise slows progression of Parkinson's disease

While vigorous exercise on a treadmill has been shown to slow the progression of Parkinson's disease in patients, the molecular reasons behind it have remained a mystery.

22 Dec 2017

Researchers use a gene-editing complex to preserve hearing in animal model of progressive deafness

Researchers have developed a CRISPR-Cas9 gene-editing complex that can be delivered directly into hair cells of the inner ear to prevent hearing loss.

21 Dec 2017

UCLA researchers reveal reversibility of Friedreich's ataxia in mouse models

In children and adults with Friedreich's ataxia, an inherited disease that causes damage to the nervous system, a loss of coordination typically progresses to muscle weakness and can involve vision, diabetes, and other problems over the course of several years.

20 Dec 2017

Study finds new way to explain hearing loss caused by cancer drug

Scientists have found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Using a highly sensitive technique to measure and map cisplatin in mouse and human inner ear tissues, researchers found that forms of cisplatin build up in the inner ear.

20 Dec 2017

Dysfunctional gene may be cause of Crohn's disease in some patients

This holiday season, millions of people will gather at airports ready to board planes for destinations around the world. Depending on the environment at their destination, their suitcases may be filled with sunscreen and bathing suits, or heavy parkas and mittens.

19 Dec 2017

Study finds combination therapy as effective strategy to treat ovarian cancers

Researchers at The Wistar Institute have found that combining PARP inhibitors, recently approved for the treatment of BRCA-mutant ovarian cancer, with another small molecule inhibitor was effective to treat ovarian cancers without BRCA1 and BRCA2 gene mutations.

19 Dec 2017

Researchers identify novel mechanism that protects from brain tumor

A group of researchers at the Spanish National Cancer Research Centre have identified a protein called RanBP6 as a new regulator of EGFR. In a paper published in Nature Communications they show how silencing of RanBP6 promoted glioma growth, by upregulating EGFR expression.

18 Dec 2017

HKBU experts develop new generation of smart anti-cancer drug molecules

The toxic nature of chemotherapy poses a great challenge to clinical treatment of cancer. A team of scholars from the School of Chinese Medicine of Hong Kong Baptist University devoted their efforts to the development of a new generation of smart anti-cancer drug molecules.

15 Dec 2017

Rare gene mutation gives rise to low sensitivity to pain

Researchers at University College London have identified a rare gene mutation in an Italian family who have little sensitivity to some forms of pain. Chronic pain caused by conditions such as lower back pain and osteoarthritis is one of the most prominent causes of disability worldwide, as assessed by the Global Burden of Disease reviews.

15 Dec 2017

Researchers team up to identify vulnerabilities of lethal parasite

An estimated 100 million people around the world are infected with Strongyloides stercoralis, a parasitic nematode, yet it's likely that many don't know it.

15 Dec 2017

Genetic variations may help identify people at high-risk for chronic pain after surgery

Genetics may play a role in determining whether patients experience chronic pain after surgery, suggests a study published today in the Online First edition of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists

14 Dec 2017

Autism treatment: Social impairments can be corrected by brain stimulation

Scientists are examining the feasibility of treating autistic children with neuromodulation after a new study showed social impairments can be corrected by brain stimulation.

13 Dec 2017

Researchers suggest role for MKL1 protein in development of inflammatory bowel disease

Inflammatory bowel disease (IBD), including the two conditions ulcerative colitis and Crohn's disease, results in long-term inflammation of the gut and is associated with dysregulation of the immune system.

13 Dec 2017

Cellular self-digestion process plays role in development of autoimmune diseases

Autophagy allows cells to degrade and recycle their cellular components. Researchers at UZH have now demonstrated that the autophagy machinery in certain immune cells leads to the immune system attacking the central nervous system.

13 Dec 2017

UQ researchers create new and improved version of ‘love hormone’

A new and improved version of the ‘love hormone’ oxytocin has been developed by University of Queensland researchers.

13 Dec 2017

Canola oil linked to worsening of Alzheimer’s

Canola oil has been marketed as a healthy cooking oil choice because of the low levels of saturated fats that is seen in it. Now a new study has revealed that consumption of canola oil could be linked to worsening of memory functions and learning ability in patients with Alzheimer’s disease.

11 Dec 2017

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

Researchers have discovered a mechanism of resistance to checkpoint inhibitors and how to reverse it. The biomarker results from the IMvigor210 study are reported at the ESMO Immuno Oncology Congress 2017.

8 Dec 2017

Mouse Model News and Research

Reduced activity of transcription factor plays key role in triggering pulmonary fibrosis

Researchers find more precise, neuroprotective approach to fix MS-damaged nerves

T cell-inducing dengue vaccines could confer broader protection for kids born to vaccinated mothers

Scientists elucidate why exercise slows progression of Parkinson's disease

Researchers use a gene-editing complex to preserve hearing in animal model of progressive deafness

UCLA researchers reveal reversibility of Friedreich's ataxia in mouse models

Study finds new way to explain hearing loss caused by cancer drug

Dysfunctional gene may be cause of Crohn's disease in some patients

Study finds combination therapy as effective strategy to treat ovarian cancers

Researchers identify novel mechanism that protects from brain tumor

HKBU experts develop new generation of smart anti-cancer drug molecules

Rare gene mutation gives rise to low sensitivity to pain

Researchers team up to identify vulnerabilities of lethal parasite

Genetic variations may help identify people at high-risk for chronic pain after surgery

Autism treatment: Social impairments can be corrected by brain stimulation

Researchers suggest role for MKL1 protein in development of inflammatory bowel disease

Cellular self-digestion process plays role in development of autoimmune diseases

UQ researchers create new and improved version of ‘love hormone’

Canola oil linked to worsening of Alzheimer’s

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

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