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TSRI researchers show path to developing treatments for Charcot-Marie-Tooth disease

Scientists at The Scripps Research Institute have now shown a path to developing treatments for disease subtype CMT2D.

8 Mar 2018

New study examines origin of cryptococcosis within the central nervous system

A particular fungal infection is responsible for more than 220,000 cases of cryptococcosis worldwide each year in people with HIV and AIDS, with nearly 181,000 of those resulting in death.

8 Mar 2018

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

Sanford Burnham Prebys Medical Research Institute researchers have published two new studies in Neuron that describe how TREM2, a receptor found on immune cells in the brain, interacts with toxic amyloid beta proteins to restore neurological function.

8 Mar 2018

Researchers determine cause of difficult-to-control mitochondrial diseases

A Japanese research group has discovered that taurine is conjugated with mitochondrial transfer RNAs (tRNAs), small RNAs that decode genetic information, and that taurine deficiency in tRNA dramatically reduces both mitochondrial protein translation and impairs mitochondrial membrane integrity.

7 Mar 2018

Researchers reveal new molecular target to help ease asthma symptoms

Researchers at UC Davis Health and Albany Medical College have shown that the protein vascular endothelial growth factor A -- or VEGFA -- plays a major role in the inflammation and airway obstruction associated with asthma.

7 Mar 2018

Preventing metabolic exhaustion in immune cells could enhance effects of immunotherapy

If you're an immune cell gearing up to fight cancer, you'd better eat your breakfast. The tumor microenvironment is a harsh place, and tumor cells are ready to wear you out.

6 Mar 2018

Study sheds light on neuronal responses in ALS

In a recent study, scientists have linked changes in the size of motor neurons to the onset of symptoms in motor neurone disease (ALS).

5 Mar 2018

Researchers gain better understanding of anatomically distinct microcircuit brain networks

Roberto Fernández Galán, an assistant professor of electrical engineering and computer science at the university's School of Engineering, and a team of undergraduate researchers at Case Western Reserve have been recording the electrical activity of hundreds of neurons as they fire inside the brain of a mouse model-for up to half an hour at a time.

1 Mar 2018

CRISPR-like gene editing could be potential way to treat patients with harmful blood lipid levels

Using a variation of CRISPR gene editing may be a potential strategy for mimicking the protective effects of a genetic mutation linked to lower cholesterol levels and heart disease risks, according to new mouse research from the Perelman School of Medicine at the University of Pennsylvania published this week in Circulation.

28 Feb 2018

Penn study sheds new light on immune cell identity

Almost all cells in the human body have identical DNA sequences, yet there are 200-plus cell types with different sizes, shapes, and chemical compositions. Determining what parts of the genome are read to make protein and which are silenced is orchestrated by proteins called transcription factors.

21 Feb 2018

Study finds novel therapeutic strategy that preserves neuromuscular synapses in ALS mouse model

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, causes lethal respiratory paralysis within several years of diagnosis. There are no effective treatments to slow or halt this devastating disease.

21 Feb 2018

Bioactive compound limits collateral damage in the kidneys after heart attack

A heart attack triggers an acute inflammatory response at the damaged portion of the heart's left ventricle. If this acute inflammation lingers, it can lead to stretching of the ventricle and heart failure. The inflammation can claim another victim -- the kidneys.

21 Feb 2018

Lab-grown cerebellar cells may help explain how ASD develops at molecular level

Increasing evidence has linked autism spectrum disorder with dysfunction of the brain's cerebellum, but the details have been unclear. In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex, a genetic syndrome that often includes ASD-like features.

19 Feb 2018

Texas Biomed and The Children’s Hospital of San Antonio join forces to cure mysterious condition

Texas Biomedical Research Institute and The Children's Hospital of San Antonio have joined forces to cure a mysterious condition called Kawasaki disease.

15 Feb 2018

Cervical tumors may be vulnerable to therapies that attack cancer's fuel supply, study shows

Cancer therapies have improved -- in some cases dramatically -- over the past two decades, but treatment for cervical cancer has remained largely unchanged. All patients receive radiation and chemotherapy, yet despite the aggressive approach, the regimen fails in about one-third of patients with cervical cancer that has spread beyond the cervix but not outside the pelvis.

15 Feb 2018

Scientists program nanorobots to shrink tumors

In a major advancement in nanomedicine, Arizona State University scientists, in collaboration with researchers from the National Center for Nanoscience and Technology, of the Chinese Academy of Sciences, have successfully programmed nanorobots to shrink tumors by cutting off their blood supply.

12 Feb 2018

Cholesterol and other lipids in the blood play role in many diseases

Lipids are fatty molecules that play important signaling and storage roles in the body, but having an excess of some lipids, like cholesterol, is a risk factor for many metabolic diseases.

8 Feb 2018

HDAC6 inhibition could be promising therapeutic approach for peripheral neuropathies

Inhibiting HDAC6 improves the structural stability of cells and protects against neuronal damage. Leuven research uncovered that targeting this mechanism could be a promising therapeutic approach for peripheral neuropathies, whether due to Charcot-Marie-Tooth disease (CMT) or as a side effect of chemotherapy.

8 Feb 2018

Mitochondrial DNA may play more important role in metastatic cancer than previously thought

DNA found in the mitochondria may play a more significant role in metastatic cancer than originally thought.

6 Feb 2018

Compounds derived from hops may improve cognitive, other functions in metabolic syndrome patients

A group of compounds derived from hops can likely improve cognitive and other functions in people with metabolic syndrome, new research at Oregon State University and Oregon Health & Science University suggests.

5 Feb 2018

Mouse Model News and Research

TSRI researchers show path to developing treatments for Charcot-Marie-Tooth disease

New study examines origin of cryptococcosis within the central nervous system

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

Researchers determine cause of difficult-to-control mitochondrial diseases

Researchers reveal new molecular target to help ease asthma symptoms

Preventing metabolic exhaustion in immune cells could enhance effects of immunotherapy

Study sheds light on neuronal responses in ALS

Researchers gain better understanding of anatomically distinct microcircuit brain networks

CRISPR-like gene editing could be potential way to treat patients with harmful blood lipid levels

Penn study sheds new light on immune cell identity

Study finds novel therapeutic strategy that preserves neuromuscular synapses in ALS mouse model

Bioactive compound limits collateral damage in the kidneys after heart attack

Lab-grown cerebellar cells may help explain how ASD develops at molecular level

Texas Biomed and The Children’s Hospital of San Antonio join forces to cure mysterious condition

Cervical tumors may be vulnerable to therapies that attack cancer's fuel supply, study shows

Scientists program nanorobots to shrink tumors

Cholesterol and other lipids in the blood play role in many diseases

HDAC6 inhibition could be promising therapeutic approach for peripheral neuropathies

Mitochondrial DNA may play more important role in metastatic cancer than previously thought

Compounds derived from hops may improve cognitive, other functions in metabolic syndrome patients

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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