Precision Medicine News and Research

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Novel genomics model allows personalized approach to radiation therapy

Cancer therapeutics is currently in the era of precision medicine - personalized medicine for individual patients based on their tumor biology.

20 Dec 2016

AMP publishes joint guidelines for interpretation, reporting of sequence variants in cancer

The Association for Molecular Pathology (AMP), the premier global, non-profit molecular diagnostics professional society, today published guideline recommendations for both clinical laboratory professionals and oncologists that assess the status of next-generation sequencing (NGS)-based cancer tests and establish standardized classification, annotation, interpretation, and reporting conventions for somatic sequence variants.

17 Dec 2016

Scientists isolate and characterize therapy-resistant dormant leukemia cells

Dr. Irmela Jeremias from Helmholtz Zentrum München and her colleagues have succeeded in finding a small population of inactive leukemia cells that is responsible for relapse of the disease.

15 Dec 2016

New technique uses focused ultrasound to detect cancer biomarkers in the blood

Each year, thousands of Canadian men with prostate cancer undergo biopsies to help their doctors better understand the progression and nature of their disease. It provides vital, sometimes life-saving information, yet cancer researcher John Lewis knows it can be a difficult test to ask of anyone.

15 Dec 2016

New Forsyth study provides new foundation for fighting Sjögren's syndrome

Sjögren's syndrome is the second most common autoimmune disease affecting four million Americans--yet treatments are limited due to a lack of knowledge about its causes.

14 Dec 2016

Phenotypic Personalized Medicine could surmount treatment challenges for acute lymphoblastic leukemia

A team of UCLA bioengineers has demonstrated that its technology may go a long way toward overcoming the challenges of treatment for acute lymphoblastic leukemia, among the most common types of cancer in children, and has the potential to help doctors personalize drug doses.

14 Dec 2016

UNMC seeking patients with lymphoma to evaluate two-drug oral therapy

The University of Nebraska Medical Center is seeking 24 patients to enroll in a Phase 2a study to evaluate the safety and efficacy of two oral cancer drugs for patients with diffuse large B-cell lymphoma who have relapsed or are resistant to other traditional therapies.

9 Dec 2016

Study identifies recurrent genomic alterations in subset of breast cancer

A genomic analysis study by Rutgers Cancer Institute of New Jersey investigators and other colleagues has identified recurrent genomic alterations in a subset of breast cancer that are typically associated with a form of thyroid cancer and an intestinal birth defect known as Hirschsprung disease.

9 Dec 2016

New model can simplify process of mixing perfect drug cocktails

Drug cocktails, such as those for treating cancer, are best when the proper ingredients are mixed in the right proportions - just like the alcoholic versions offered at the local bar.

9 Dec 2016

Scientists discover truncated p53 proteins that promote cancer growth and metastasis

Discovered in the 1970s, tumor suppressors are among the most important proteins in the body.

8 Dec 2016

Scientists use unified analysis approach for diagnosing diseases with multiple genetic causes

Scientists at Baylor College of Medicine, Baylor Genetics, the University of Texas Health Science Center at Houston and Texas Children's Hospital are combining descriptions of patients' clinical features with their complex genetic information in a unified analysis to obtain more precise diagnoses of complex diseases, particularly those that involve more than one gene causing the condition.

8 Dec 2016

Synthetic sgRNA for CRISPR genome editing

Chemically synthesized single guide RNA is the best way to do CRISPR genome editing. It is more pure than biological methods of creating guide RNAs, like in vitro transcription or plasmids. As a result, sgRNA leads to more consistency and higher quality.

8 Dec 2016

New study suggests how risk gene linked to ADHD may work

Genetics play a strong part in the development of attention-deficit/hyperactivity disorder (ADHD), but the path from a gene to risk for the disorder has remained a black box to researchers.

7 Dec 2016

Researchers find strong link between angiotensin receptor autoantibodies and increased risk of frailty

Results of a new study led by Johns Hopkins researchers offer new evidence for a strong link between angiotensin receptor autoantibodies and increased risk of frailty.

6 Dec 2016

3D-printed organ models could aid individualized dosimetry in nuclear medicine

In nuclear medicine, the goal is to keep radiation exposure at a minimum, while obtaining quality images.

6 Dec 2016

Researchers to create personalized health informatics platform to improve care coordination

Researchers at The University of Texas at Dallas will take part in a project that aims to design and construct a patient-focused and personalized health system that addresses the currently fractured structure of health care information.

2 Dec 2016

Novel imaging agent can rapidly and accurately detect metastasis of prostate cancer

New research demonstrates that a novel imaging agent can quickly and accurately detect metastasis of prostate cancer, even in areas where detection has previously been difficult.

2 Dec 2016

New study finds genetic link between Parkinson's disease and cognitive decline

Although the hallmark symptoms of Parkinson's disease (PD) - such as involuntary shaking, slowness of movement and muscle rigidity - are related to movement, recent evidence has suggested that memory impairment plays an outsized role in diminished quality of life and the burden placed on caregivers.

1 Dec 2016

OHSU scientists identify potential target for preventing and treating Alzheimer's disease

A new scientific discovery may provide a future avenue for treatment and prevention of Alzheimer's disease.

1 Dec 2016

Nature Methods publishes comparative study of leading Protein-Protein Interaction Networks

Nature Methods published (online) a comparative study of leading Protein-Protein Interaction (PPI) Networks.

1 Dec 2016

Precision Medicine News and Research

Novel genomics model allows personalized approach to radiation therapy

AMP publishes joint guidelines for interpretation, reporting of sequence variants in cancer

Scientists isolate and characterize therapy-resistant dormant leukemia cells

New technique uses focused ultrasound to detect cancer biomarkers in the blood

New Forsyth study provides new foundation for fighting Sjögren's syndrome

Phenotypic Personalized Medicine could surmount treatment challenges for acute lymphoblastic leukemia

UNMC seeking patients with lymphoma to evaluate two-drug oral therapy

Study identifies recurrent genomic alterations in subset of breast cancer

New model can simplify process of mixing perfect drug cocktails

Scientists discover truncated p53 proteins that promote cancer growth and metastasis

Scientists use unified analysis approach for diagnosing diseases with multiple genetic causes

Synthetic sgRNA for CRISPR genome editing

New study suggests how risk gene linked to ADHD may work

Researchers find strong link between angiotensin receptor autoantibodies and increased risk of frailty

3D-printed organ models could aid individualized dosimetry in nuclear medicine

Researchers to create personalized health informatics platform to improve care coordination

Novel imaging agent can rapidly and accurately detect metastasis of prostate cancer

New study finds genetic link between Parkinson's disease and cognitive decline

OHSU scientists identify potential target for preventing and treating Alzheimer's disease

Nature Methods publishes comparative study of leading Protein-Protein Interaction Networks

Editorial Focus eBook - Peptides and Oligonucleotides (2nd edition) eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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