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Unlocking ACE2: The enzyme that links COVID-19, heart disease, and diabetes

A recent study in the Journal of Biomedical Science examines the critical role of ACE2, an enzyme involved in blood volume and electrolyte balance, in chronic diseases like cardiovascular conditions, diabetes, and COVID-19. The research suggests that ACE2 could serve as both a disease severity biomarker and a therapeutic target.

28 Aug 2023

Experts warn of unintended consequences of using GLP-1RAs to treat childhood obesity

A team of clinicians, exercise scientists, pharmaceutical scholars, ethicists and behavioral experts at the University of California, Irvine, outlined their concerns that the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) to treat childhood obesity and type 2 diabetes may have unintended and adverse consequences for children's health.

28 Aug 2023

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

The review summarized the involvement of mitochondria in age-related disease progression and highlighted its potential as a therapeutic target of these diseases.

28 Aug 2023

Study shows benefit of traditional Chinese medicine for heart failure

The traditional Chinese medicine qiliqiangxin reduces hospitalization for heart failure and cardiovascular death in patients with heart failure and a reduced ejection fraction (HFrEF), according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

28 Aug 2023

The potential of gut-microbiota-targeted reprogramming interventions designed to prevent the onset and progression of cardiovascular diseases

Researchers discuss the potential of probiotic- and prebiotic-based interventions for managing cardiovascular diseases.

28 Aug 2023

Adolescence stress exposure impacts rodent brain development and behavior

Adolescence stress exposure in rodents can lead to reduced hippocampal cell proliferation, neuroplasticity, and cognitive impairments, as well as increased depressive-like behaviors. These effects may persist into adulthood but with variable impact.

27 Aug 2023

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

In 2012, University of Alabama at Birmingham researcher Anath Shalev, M.D., reported that a decades-old blood pressure medication called verapamil completely reversed diabetes in animal models.

25 Aug 2023

New 3D model mimics brain cell and immune cell interactions in Alzheimer's disease

Cognitive decline associated with Alzheimer's disease (AD) develops when neurons begin to die, which can be caused by inappropriate immune responses and excessive inflammation in the brain triggered by amyloid beta deposits and tau tangles, two hallmarks of the disease.

25 Aug 2023

Semaglutide could be a game-changer for patients with HFpEF and obesity

Semaglutide improves heart failure-related symptoms and physical function and results in greater weight loss compared with placebo in patients with heart failure with preserved ejection fraction (HFpEF) and obesity, according to late-breaking research presented in a Hot Line session today at ESC Congress 2023.

25 Aug 2023

New ESC Guidelines for the management of cardiovascular disease in patients with diabetes released

Patients with type 2 diabetes are more than twice as likely to develop cardiovascular disease (CVD) than their healthy peers.

25 Aug 2023

The role of orexin in the modulation of sleep and wakefulness

The current evidence of the intricate relationship between orexin, rapid eye movement (REM) sleep, and appetite.

24 Aug 2023

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Researchers investigated whether anti‑interleukin 6 monoclonal antibodies were related to heterogenous treatment effects between male and female COVID-19 patients.

24 Aug 2023

Study shows that CD98hc can be targeted to deliver biotherapeutics in brain

Researchers engineered and characterized a blood-brain barrier transport vehicle targeting the CD98 heavy chain of heterodimeric amino acid transporters.

24 Aug 2023

Study shows how cancer can selfishly hijack a helpful immune pathway to spread

A study led by researchers at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine discovered a new relationship between cancer cells and the immune system, and shows how cancer can selfishly hijack a normally helpful immune pathway.

23 Aug 2023

New targeted therapy zolbetuximab extends survival for patients with advanced gastric cancer

An international phase 3 clinical trial, done in participation with Weill Cornell Medicine and NewYork-Presbyterian, found that a new targeted treatment called zolbetuximab, given in combination with a standard chemotherapy, extended survival for patients with advanced gastric or gastroesophageal junction cancer that overexpressed a specific biomarker.

23 Aug 2023

UC researchers study parasite that causes Chagas disease

Almost everything about insects called kissing bugs is revolting, from the insidious way they bite people's faces at night to drink their blood while they sleep to the way they spread disease through their poop.

23 Aug 2023

$9.57 million grant will support a clinical trial to study new treatment option for NAFLD

According to the National Institutes of Health, approximately 24% of adults in the United States have nonalcoholic fatty liver disease (NAFLD), an umbrella term for a range of liver conditions affecting people who drink little to no alcohol that can lead to cirrhosis, liver cancer and liver failure.

23 Aug 2023

Receptor News and Research

Unlocking ACE2: The enzyme that links COVID-19, heart disease, and diabetes

Experts warn of unintended consequences of using GLP-1RAs to treat childhood obesity

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

Study shows benefit of traditional Chinese medicine for heart failure

The potential of gut-microbiota-targeted reprogramming interventions designed to prevent the onset and progression of cardiovascular diseases

Adolescence stress exposure impacts rodent brain development and behavior

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

New 3D model mimics brain cell and immune cell interactions in Alzheimer's disease

Semaglutide could be a game-changer for patients with HFpEF and obesity

New ESC Guidelines for the management of cardiovascular disease in patients with diabetes released

The role of orexin in the modulation of sleep and wakefulness

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Study shows that CD98hc can be targeted to deliver biotherapeutics in brain

Study shows how cancer can selfishly hijack a helpful immune pathway to spread

New targeted therapy zolbetuximab extends survival for patients with advanced gastric cancer

UC researchers study parasite that causes Chagas disease

$9.57 million grant will support a clinical trial to study new treatment option for NAFLD

Artificial intelligence and polyclonal antibody sequencing redefine the future of antibody discovery

How does COVID-19 influence your gut microbiota?

NCCN publishes new resource on options, benefits of care approaches for pediatric Hodgkin lymphoma

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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