Membrane News and Research

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Researchers uncover the physics behind formation of branching microtubules during cell division

As any cook knows, some liquids mix well with each other, but others do not. For example, when a tablespoon of vinegar is poured into water, a brief stir suffices to thoroughly combine the two liquids.

30 Jan 2021

Study unravels relationship status of important receptor on immune and cancer cells

An important receptor on the surface of cancer and immune cells prefers to remain noncommittal; sometimes it is present as a single, sometimes as a pair. This was first shown by an MDC team in the journal PNAS, and will decisively advance the development of new medications.

30 Jan 2021

Discovery offers novel possibilities to target drug-resistant HER2-positive cancers

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells.

29 Jan 2021

Startup develops yeast-based test to detect the presence of SARS-CoV-2 in saliva

Incubated at the University of Campinas (UNICAMP) in the state of São Paulo, Brazil, and supported by São Paulo Research Foundation- FAPESP's Innovative Research in Small Business Program (PIPE), BIOinFOOD is a startup that is developing a rapid COVID-19 diagnostic test based on a patent application filed by students at UNICAMP's Genomics and Bioenergy Laboratory.

29 Jan 2021

Scientists unravel how lipids distribute proteins within cells

An international team of scientists, coordinated by the Seville Institute of Biomedicine and the University of Seville has solved one of the hitherto unresolved enigmas of basic biology: how exactly do lipids distribute proteins within a cell? To do this, they used a new, completely innovative microscopy technology, which they applied to "mutant" cells they designed in their laboratory.

29 Jan 2021

SORLA protein promotes the growth of breast cancer brain metastasis

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells.

29 Jan 2021

Researchers develop ‘next-generation vaccine platform’ against SARS-CoV-2

Researchers have designed a subunit vaccine based on the SARS-CoV-2 spike protein co-administered with CpG (Oligodeoxyribonucleotides) adjuvant.

29 Jan 2021

Optimizing the structure of drug delivery systems can help target cancer cells

The main culprit in cancer is healthy cells that have gone rogue and acquire the ability to divide uncontrollably.

28 Jan 2021

Substances in tick saliva activate immune response-suppressing proteins in cattle

A tick saliva study reveals immune responses that could lead to better protection for cattle.

28 Jan 2021

David Julius and Ardem Patapoutian receive Frontiers of Knowledge Award in Biology and Biomedicine

The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone in this thirteenth edition to David Julius, from the University of California, San Francisco, and Ardem Patapoutian, from the Scripps Institute, La Jolla (United States), "for identifying the receptors that enable us to sense temperature, pain and pressure."

28 Jan 2021

Could spironolactone treat COVID-19-related pneumonia and pulmonary fibrosis?

Researchers have described the potential of the drug spironolactone, a potassium-sparing diuretic, and anti-androgen, in preventing or alleviating the severity of COVID-19 pneumonia, and in preventing pulmonary fibrosis.

27 Jan 2021

What do we know about the SARS-CoV-2 vaccines so far?

A new study surveys what we know so far about SARS-CoV-2 vaccine candidates from advanced clinical trials.

27 Jan 2021

New data shows that mINDY gene is involved in blood pressure regulation

Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the Journal of Clinical Investigation (JCI) insight.

27 Jan 2021

Rapid transmission of N501Y variants may be due to favorable effects on host receptor binding

Now, in new research posted to the preprint server bioRxiv*, scientists use an experimental structure of the Spike RBD domain co-crystallized with part of the ACE2 receptor and several in silico methods to analyze the possible impacts of three amino acid replacements (Spike K417N, E484K, N501Y) concerning ACE2 binding.

27 Jan 2021

Study shows why children of obese mothers have propensity to develop metabolic diseases

A Brazilian study published in the journal Molecular Human Reproduction helps understand why obese mothers tend to have children with a propensity to develop metabolic disease during their lifetime, as suggested by previous research.

26 Jan 2021

Prostate cancer: Drug-resistant, metastasis-causing cells can produce exponentially growing tumors

The cover for issue 1 of Oncotarget features Figure 2, "Results in clinical trials," published in "Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer" by Blagoev, et al. which reported that most metastatic cancers develop drug resistance during treatment and continue to grow, driven by a subpopulation of cancer cells unresponsive to the therapy being administered.

26 Jan 2021

Researchers find microbiome-controlled anti-inflammatory subsets of astrocytes

Astrocytes are the most abundant type of cells within the central nervous system (CNS), but they remain poorly characterized.

26 Jan 2021

Codon frequency optimization shows SARS-CoV-2 antiviral potential

A study conducted by researchers in the US has revealed that optimization of codon for bacterial expression causes the production of an inactive enzyme non-structural protein 12 (Nsp12), a catalytic subunit of RNA-dependent RNA polymerase of SARS-CoV-2.

26 Jan 2021

Mutations in SARS-CoV-2 spike proteolytic cleavage sites may alter transmission dynamics

A study conducted by researchers at the University of Kentucky and the Washington University School of Medicine in the USA has revealed that mutations in the proteolytic cleavage site within the S2 subunit can alter the processing of the SARS-CoV-2 spike protein, affecting viral entry into host cells.

26 Jan 2021

Novel neutralizing antibodies targeting SARS-CoV-2 N-terminal domain discovered

A new study by US-based researchers shows the presence of protective antibodies that target the N-terminal domain (NTD) of the spike instead of the spike receptor-binding domain (RBD).

22 Jan 2021

Membrane News and Research

Researchers uncover the physics behind formation of branching microtubules during cell division

Study unravels relationship status of important receptor on immune and cancer cells

Discovery offers novel possibilities to target drug-resistant HER2-positive cancers

Startup develops yeast-based test to detect the presence of SARS-CoV-2 in saliva

Scientists unravel how lipids distribute proteins within cells

SORLA protein promotes the growth of breast cancer brain metastasis

Researchers develop ‘next-generation vaccine platform’ against SARS-CoV-2

Optimizing the structure of drug delivery systems can help target cancer cells

Substances in tick saliva activate immune response-suppressing proteins in cattle

David Julius and Ardem Patapoutian receive Frontiers of Knowledge Award in Biology and Biomedicine

Could spironolactone treat COVID-19-related pneumonia and pulmonary fibrosis?

What do we know about the SARS-CoV-2 vaccines so far?

New data shows that mINDY gene is involved in blood pressure regulation

Rapid transmission of N501Y variants may be due to favorable effects on host receptor binding

Study shows why children of obese mothers have propensity to develop metabolic diseases

Prostate cancer: Drug-resistant, metastasis-causing cells can produce exponentially growing tumors

Researchers find microbiome-controlled anti-inflammatory subsets of astrocytes

Codon frequency optimization shows SARS-CoV-2 antiviral potential

Mutations in SARS-CoV-2 spike proteolytic cleavage sites may alter transmission dynamics

Novel neutralizing antibodies targeting SARS-CoV-2 N-terminal domain discovered

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