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Novel grape-derived compounds could be developed as therapeutic agents for treatment of depression

In a study to be published online February 2 in Nature Communications, scientists from the Icahn School of Medicine at Mount Sinai describe an extensive analysis of novel grape-derived compounds, dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc),which might be developed as therapeutic agents for the treatment of depression.

2 Feb 2018

Researchers move closer to solving puzzle of 15q13.3 microdeletion syndrome

Researchers are closer to solving the puzzle of a complex neurological condition called 15q13.3 microdeletion syndrome. Individuals with this condition are missing a small piece of chromosome 15 that usually contains six genes, but which one of the genes is responsible for the clinical characteristics of patients has not been clear.

2 Feb 2018

Researchers identify cause of severe genetic disease

Mutations in the p63 protein lead to a number of disorders, but none is as severe as the AEC syndrome. Scientists at Goethe University Frankfurt in collaboration with a research group from the University of Naples Federico II have now discovered that this syndrome resembles diseases such as Alzheimer's, Parkinson's or ALS more closely than it does other p63-based syndromes.

2 Feb 2018

Two bacterial species collaborate to drive development of colon cancers

Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer, a study led by a Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy research team finds.

1 Feb 2018

Researchers use gene therapy that lengthens telomeres to cure pulmonary fibrosis in mice

Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, currently lacking effective treatment.

30 Jan 2018

Researchers reverse symptoms associated with Rett syndrome in mouse model

It is a parent's nightmare: a child is born apparently healthy, then stops meeting developmental milestones at one year old. Her verbal and motor skills vanish, and irregular breathing, seizures, and a host of other problems appear.

29 Jan 2018

Circadian rhythm disruptions occur much earlier in people at risk of Alzheimer's

People with Alzheimer's disease are known to have disturbances in their internal body clocks that affect the sleep/wake cycle and may increase risk of developing the disorder.

29 Jan 2018

Exposing the gut to chlamydia protects against subsequent genital tract infections

The protection is very robust and is across tissues, which is called transmucosal immunity. Protected sites include the genital tract and the lungs, said Dr. Zhong, whose faculty appointment is in the Department of Microbiology, Immunology & Molecular Genetics.

27 Jan 2018

Researchers identify promising new drug target for Ewing sarcoma

Screening a class of recently-developed drug compounds -- so-called "CDK inhibitors" capable of blocking CDK7/12/13 proteins -- against hundreds of different human cancer cell lines, researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center have found that CDK12 inhibitors pack a particularly lethal punch to Ewing sarcoma, a rare cancer typically affecting children and young adults.

25 Jan 2018

Researchers find new method to overcome major challenge of stem cell therapy

Researchers have discovered a new technique that overcomes one of the major challenges of stem cell therapy.

25 Jan 2018

Repurposed drug effectively protects against Zika virus in mouse models

In both cell cultures and mouse models, a drug used to treat Hepatitis C effectively protected and rescued neural cells infected by the Zika virus -- and blocked transmission of the virus to mouse fetuses.

25 Jan 2018

Scientists find how potential new eczema treatment could also alleviate asthma

Scientists from VIB-UGent have discovered insights for a possible new therapy for eczema that also reduces the severity of asthma

19 Jan 2018

Researchers discover potential target genes to halt thyroid cancer progression

Thyroid cancer is a disease with good cure rates in most cases. In 5% of patients, however, the tumor becomes refractory to the available therapies and may spread all over the body, causing death.

19 Jan 2018

Chronic traumatic encephalopathy may start early even without signs of concussions

The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic encephalopathy, and the relationships between these disorders, are poorly understood.

18 Jan 2018

Researchers use immune-mimicking biomaterial scaffolds to fast track T cell therapies

Immunologists and oncologists are harnessing the body's immune system to fight cancers and other diseases with adoptive cell transfer techniques. In a normal immune response, a type of white blood cell known as T cells are instructed by another kind of immune cell called an antigen-presenting cell (APC) to expand their numbers and stay alive.

15 Jan 2018

Research sheds new light on genetic, environmental factors that promote prostate cancer metastasis

Prostate tumors tend to be what scientists call "indolent" - so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, the disease is invariably fatal.

15 Jan 2018

Research provides insights into mechanisms governing healthy longevity

Keio University Global Research Institute, Tokyo publishes the January 2018 issue of KGRI Research Frontiers that includes researcher video profiles of Keio University researchers and research highlights from high impact publications including 'Regenerative medicine needs collaboration in and out of science in order to face current and future challenges; ‘Does eating fish protect you from depression?’; ‘Insights into the molecular mechanisms leading to kidney dysfunction in diabetic patients’; and ‘Ageing to 100 and beyond: Insights from demographic, phenotypic and genetic studies.

12 Jan 2018

Novel antifungal shows promise to stave off drug-resistant superbugs

Microscopic yeast have been wreaking havoc in hospitals around the world- creeping into catheters, ventilator tubes, and IV lines- and causing deadly invasive infection.

11 Jan 2018

Stress accelerates development of pancreatic cancer, study shows

A new study shows that stress accelerates the development of pancreatic cancer by triggering the release of "fight-or-flight" hormones. Beta-blockers--commonly used medications that inhibit these hormones--were found to increase survival in a mouse model of the disease.

10 Jan 2018

Study identifies how excess fat disrupts heart cells' ability to produce energy

A University of Iowa study has identified how excess fat in the heart, a common feature in diabetes and obesity, can harm the cells' essential ability to produce energy.

5 Jan 2018

Mouse Model News and Research

Novel grape-derived compounds could be developed as therapeutic agents for treatment of depression

Researchers move closer to solving puzzle of 15q13.3 microdeletion syndrome

Researchers identify cause of severe genetic disease

Two bacterial species collaborate to drive development of colon cancers

Researchers use gene therapy that lengthens telomeres to cure pulmonary fibrosis in mice

Researchers reverse symptoms associated with Rett syndrome in mouse model

Circadian rhythm disruptions occur much earlier in people at risk of Alzheimer's

Exposing the gut to chlamydia protects against subsequent genital tract infections

Researchers identify promising new drug target for Ewing sarcoma

Researchers find new method to overcome major challenge of stem cell therapy

Repurposed drug effectively protects against Zika virus in mouse models

Scientists find how potential new eczema treatment could also alleviate asthma

Researchers discover potential target genes to halt thyroid cancer progression

Chronic traumatic encephalopathy may start early even without signs of concussions

Researchers use immune-mimicking biomaterial scaffolds to fast track T cell therapies

Research sheds new light on genetic, environmental factors that promote prostate cancer metastasis

Research provides insights into mechanisms governing healthy longevity

Novel antifungal shows promise to stave off drug-resistant superbugs

Stress accelerates development of pancreatic cancer, study shows

Study identifies how excess fat disrupts heart cells' ability to produce energy

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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