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Innovative tool helps observe protein aggregates linked to neurodegenerative diseases

For rent: 32 individual rooms for a combined surface area of 4cm2, heating and food included! Biologists and microfluidics specialists at EPFL have joined forces and developed a highly innovative research tool: a 2cm by 2cm 'chip' with 32 independent compartments, each of which is designed to hold a nematode - a widely used worm in the research world. The device is described in the journal Molecular Neurodegeneration.

16 Feb 2016

Electronic health records could help identify people who have undiagnosed type 2 diabetes

In 2012, a group of UCLA researchers set out to mine thousands of electronic health records for a more accurate and less expensive way to identify people who have undiagnosed type 2 diabetes. The researchers got much more than they bargained for.

16 Feb 2016

Heart attack patients experiencing cardiogenic shock at higher risk of death in first 60 days post-discharge

Heart attack patients who experience cardiogenic shock have a higher risk of death or rehospitalization than non-shock patients in the first 60 days post-discharge, but by the end of the first year, the gap between the two groups narrows, according to a study published today in the Journal of the American College of Cardiology.

16 Feb 2016

Regrowing dopaminergic neurons may lead to new therapy for Parkinson's disease

While scientists are unsure of the molecular causes of Parkinson's Disease, they do know the disorder's tremors and other motor dysfunctions are linked to a loss of dopaminergic neurons located in the substantia nigra, a structure in the midbrain.

16 Feb 2016

One specific microRNA has strong links to autism spectrum disorder, say TSRI scientists

Discovered only in the 1990s, microRNAs are short molecules that work within virtually all cells. Typically, each one functions as a “dimmer switch” for the expression of one or more genes, regulating a wide variety of cellular processes, including learning and memory.

16 Feb 2016

Variations in Tie2 gene play significant role in patient responses to infections

Major infections such as influenza and bacterial sepsis kill millions of people each year, often resulting fro dangerous complications that impair the body's blood vessels. But the reasons why some patients experience these dramatic responses to infections -- and others don't -- have been unclear.

16 Feb 2016

Research findings identify potential genetics-guided precision medicine for leukemia patients

An international research team has determined how inherited gene variations lead to severe drug toxicity that may threaten chances for a cure in children with leukemia. St. Jude Children's Research Hospital scientists led the study, results of which set the stage to expand the use of a patient's genetic make-up to tailor chemotherapy.

16 Feb 2016

St. Jude-led scientists explore better ways to use blood-forming stem cells for therapeutic interventions

A team of researchers led by scientists at St. Jude Children's Research Hospital is looking at ways to improve how blood-forming stem cells can be used for therapeutic interventions. The work has uncovered a group of genes that regulate how hematopoietic stem cells start to grow and thrive in mice. The function of many of these genes was previously unknown. Reconstitution of a robust blood-forming system is essential for recovery from many catastrophic diseases as well as from chemotherapy treatments.

16 Feb 2016

Hereditary spastic paraplegia characteristics unveiled

Researchers have detailed the characteristics of a large cohort of patients with hereditary spastic paraplegias.

15 Feb 2016

Human brains prioritize and reinforce high-reward memories

Why do we remember some events, places and things, but not others? Our brains prioritize rewarding memories over others, and reinforce them by replaying them when we are at rest, according to new research from the University of California, Davis, Center for Neuroscience, published Feb. 11 in the journal Neuron.

15 Feb 2016

Household and outdoor air pollution kills more than 5.5 million people every year

New research shows that more than 5.5 million people die prematurely every year due to household and outdoor air pollution. More than half of deaths occur in two of the world's fastest growing economies, China and India.

15 Feb 2016

Neural gene promotes growth and spread of metastatic breast cancer

When breast cancer becomes advanced and spreads to other organs, patient survival is drastically reduced, prompting the need to explore the genes that may cause tumor cells to metastasize.

15 Feb 2016

GWAS can help pinpoint genetic variants that predict lifestyle risks for diseases

Genome wide association studies (GWAS) scan the entire genome in order to pinpoint genetic variants associated with a particular disease. The technique is employed to identify biological pathways - the series of actions and changes that have occurred in cells and genetic material - that can be linked to the causation of a disease.

15 Feb 2016

Discovery opens door to preventing diet-induced heart disease

Four years ago, Stanley Hazen, MD, PhD, Chair of Cellular and Molecular Medicine, and colleagues made a landmark discovery linking intestinal bacteria to heart disease. His team found that when our digestive systems digest the nutrients carnitine and choline (abundant in red meat and eggs, respectively), a bacterial waste product called TMAO is formed. They showed that high levels of TMAO are associated with higher rates of heart attack, stroke and cardiac death.

14 Feb 2016

X linked News and Research

Innovative tool helps observe protein aggregates linked to neurodegenerative diseases

Electronic health records could help identify people who have undiagnosed type 2 diabetes

Heart attack patients experiencing cardiogenic shock at higher risk of death in first 60 days post-discharge

Regrowing dopaminergic neurons may lead to new therapy for Parkinson's disease

One specific microRNA has strong links to autism spectrum disorder, say TSRI scientists

Variations in Tie2 gene play significant role in patient responses to infections

Research findings identify potential genetics-guided precision medicine for leukemia patients

St. Jude-led scientists explore better ways to use blood-forming stem cells for therapeutic interventions

Hereditary spastic paraplegia characteristics unveiled

Human brains prioritize and reinforce high-reward memories

Household and outdoor air pollution kills more than 5.5 million people every year

Neural gene promotes growth and spread of metastatic breast cancer

GWAS can help pinpoint genetic variants that predict lifestyle risks for diseases

Discovery opens door to preventing diet-induced heart disease

Left ventricular tissue phase mapping predicts PAH outcomes

Worsening migraine no reason to halt dihydroergotamine infusion

Anti-TNF therapy linked to ‘modest’ extra SCC risk

Tick genome study sheds light on occurrences of Lyme disease

Poor physical fitness in middle age linked to smaller brain size 20 years later

Gastric bypass surgery linked to long-term survival for patients over age 35

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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