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Mutations in EBOV-Makona do not alter disease-causing ability in animal models, shows study

Early during the recent Ebola epidemic in West Africa, scientists speculated that the genetic diversity of the circulating Makona strain of virus (EBOV-Makona) would result in more severe disease and more transmissibility than prior strains.

9 May 2018

Researchers uncover the cause of scarring in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is one of the most challenging and frustrating diseases that pulmonologists face.

9 May 2018

Allen Institute for Cell Science launches first predictive and comprehensive, 3D model of live human cell

The Allen Institute for Cell Science today launched the first predictive and comprehensive, 3D model of a live human cell, the Allen Integrated Cell.

9 May 2018

New findings point to potential therapeutic avenues for leukemia

Scientists have known for decades that the Hox family of transcription factors are key regulators in the formation of blood cells and the development of leukemia.

9 May 2018

Centrosome amplification may contribute to initiation of cancers, research suggests

Cells begin to accumulate centrosomes - organelles that play a vital role during cell division - before they transform into cancer cells, according to a new study of patients with Barrett's esophagus condition, which is associated with esophageal cancer.

8 May 2018

Scientists discover how potential new drug targets spinal muscular atrophy

Spinal muscular atrophy (SMA) is a genetic disease that can leave infants with weak muscles and trouble breathing. Many with the disease die before age two. To help these patients, doctors need therapies that target the genetic mutation and stop its progression.

8 May 2018

Study finds new molecular mechanism for neurodegeneration in frontotemporal dementia

A new study in Biological Psychiatry reports that dementia-related and psychiatric-related proteins cluster together to form aggregates in the brain, leading to abnormal cell function and behavior.

8 May 2018

Neon Therapeutics evaluates safety, efficacy of NEO-PV-01 in combination with KEYTRUDA and chemotherapy

Neon Therapeutics, a clinical-stage immuno-oncology company developing neoantigen-based therapeutics, today announced that it has treated the first patient in a clinical trial evaluating its proprietary personal neoantigen vaccine, NEO-PV-01, in combination with Merck's anti-PD-1 therapy, KEYTRUDA®, along with chemotherapy.

8 May 2018

Researchers harness the precision of CRISPR to knock out single genes in yeast

Researchers have used CRISPR-Cas9 to develop a technology that can precisely target any gene in the yeast species Saccharomyces cerevisiae.

8 May 2018

Scientists discover a small family of proteins that control inclusion of DNA methylation marks in genome

Not all of your genome needs to be active at any given time. Some regions are prone to hopping around the genome in problematic ways if left unchecked; others code for genes that need to be turned off in certain cells or at certain times.

8 May 2018

PFKFB3 enzyme appears to play a key role in pulmonary hypertension

A new and early target for treating pulmonary hypertension appears to be an enzyme that's normally key to energy production but destructive in the face of this high blood pressure inside your lungs.

8 May 2018

Researchers create a biomaterial that can be used to study the brain

Researchers have created a new type of biomaterial that can support the growth of nerve cells, potentially opening up new possibilities for patients who have experienced a stroke or traumatic brain injury.

8 May 2018

Simplified Mammalian Cell Harvesting without Centrifuging

Centrifuging adds time and can potentially damage the cell sample, Michael Grauf discusses how cell clarification and sterile filtration can be achieved in one step.

From Sartorius 8 May 2018

New chemical trap catches trace glycoproteins, shows promise for targeted cancer treatments

Cancer drops sparse chemical hints of its presence early on, but unfortunately, many of them are in a class of biochemicals that could not be detected thoroughly, until now.

8 May 2018

New research identifies critical function of PDK1 pathway that contributes to cancer metastasis

Cancer is most devastating when it metastasizes--when tumor cells break away, travel through the bloodstream, and then attach elsewhere, only to grow another tumor.

8 May 2018

Using human induced pluripotent stem cells for therapeutic drug testing

Researchers at Li Ka Shing Faculty of Medicine of The University of Hong Kong have successfully demonstrated the use of human induced pluripotent stem cells from patients' skin cells for therapeutic drug testing.

8 May 2018

New FSMB report recommends best practices for regulating physicians' use of stem cell treatments

The Federation of State Medical Boards has released a report recommending best practices for regulating the promotion, communication and practices of treatments received at stem cell clinics in the United States.

8 May 2018

Study identifies new biomarker for early lung cancer diagnosis

High levels of cytoskeleton-associated protein 4 (CKAP4) have been identified in the blood of patients with lung cancer.

8 May 2018

FDA grants approval for two drugs administered together to treat aggressive form of thyroid cancer

The U.S. Food and Drug Administration approved Tafinlar (dabrafenib) and Mekinist (trametinib), administered together, for the treatment of anaplastic thyroid cancer (ATC) that cannot be removed by surgery or has spread to other parts of the body (metastatic), and has a type of abnormal gene, BRAF V600E (BRAF V600E mutation-positive).

8 May 2018

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Functional loss of ARID1a, a frequently mutated tumor suppressor gene, causes deficiencies in normal DNA repair and may sensitize tumors to immune checkpoint blockade therapies, according to researchers from The University of Texas MD Anderson Cancer Center.

8 May 2018

B Cell News and Research

Mutations in EBOV-Makona do not alter disease-causing ability in animal models, shows study

Researchers uncover the cause of scarring in idiopathic pulmonary fibrosis

Allen Institute for Cell Science launches first predictive and comprehensive, 3D model of live human cell

New findings point to potential therapeutic avenues for leukemia

Centrosome amplification may contribute to initiation of cancers, research suggests

Scientists discover how potential new drug targets spinal muscular atrophy

Study finds new molecular mechanism for neurodegeneration in frontotemporal dementia

Neon Therapeutics evaluates safety, efficacy of NEO-PV-01 in combination with KEYTRUDA and chemotherapy

Researchers harness the precision of CRISPR to knock out single genes in yeast

Scientists discover a small family of proteins that control inclusion of DNA methylation marks in genome

PFKFB3 enzyme appears to play a key role in pulmonary hypertension

Researchers create a biomaterial that can be used to study the brain

Simplified Mammalian Cell Harvesting without Centrifuging

New chemical trap catches trace glycoproteins, shows promise for targeted cancer treatments

New research identifies critical function of PDK1 pathway that contributes to cancer metastasis

Using human induced pluripotent stem cells for therapeutic drug testing

New FSMB report recommends best practices for regulating physicians' use of stem cell treatments

Study identifies new biomarker for early lung cancer diagnosis

FDA grants approval for two drugs administered together to treat aggressive form of thyroid cancer

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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