Genes News and Research

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Celebrex like gene suppresses the growth of colon cancer

Cancer researchers at the Case Western Reserve University (Case) School of Medicine, University Hospitals of Cleveland (UHC) and the Howard Hughes Medical Institute have found a "Celebrex-like" gene that suppresses the growth of colon cancer.

13 Dec 2004

New approach to genomic testing identifies women with low risk of breast cancer recurrence

An initial validation study presented by Exagen Diagnostics at the San Antonio Breast Cancer Symposium suggests it may soon be possible to distinguish good prognosis from poor prognosis in any newly diagnosed breast cancer patient based on DNA changes in the patient's tumor.

13 Dec 2004

Study of early stage breast cancer patients identifies women at low risk of breast cancer mortality

Kaiser Permanente researchers are presenting results of a large epidemiologic study of a unique breast cancer test at the 27th Annual San Antonio Breast Cancer Symposium. The KP study shows the test can identify patients with early stage disease who are at low risk of breast cancer death at 10-years.

13 Dec 2004

First gene therapy for skin cancer

Researchers at UT Southwestern Medical Center at Dallas have successfully tested the first gene therapy for skin cancer, using a mouse model for the disease xeroderma pigmentosum, or XP.

13 Dec 2004

Using precise, radioactively labeled genetic probes, researchers study cancer gene activity from outside the body

Using precise, radioactively labeled genetic probes, researchers at Jefferson Medical College have seen cancer gene activity from outside the body in laboratory mice. The probes, which work by attaching to genetic codes copied from an active cancer gene, may someday aid physicians and scientists in cancer detection and in determining the appropriate treatment for a cancer.

13 Dec 2004

Discovery of key immune system molecules that helps determine how effectively a person resists HIV infection

A team of researchers based partly in South Africa has identified a key set of immune system molecules that helps determine how effectively a person resists infection with human immunodeficiency virus (HIV).

8 Dec 2004

New technology will advance our understanding of role of complex sugar chains decorating the surface of cells in the body

An international consortium of scientists lead by Dr. James Paulson of The Scripps Research Institute has created a technology that will advance our understanding of the role of complex sugar chains (glycans or carbohydrates) that decorate the surface of cells in the body.

8 Dec 2004

New research is allowing biochemists to understand a key hierarchy of protein interactions that occurs in DNA

"All cancers are marked by some form of DNA replication gone awry, so a basic understanding of DNA replication is of paramount importance to those designing cancer-fighting drugs,"

8 Dec 2004

Defect in one of nature's oldest proteins may be an underlying cause in human miscarriages

University of Rochester scientists studying a vital protein called Serum Response Factor (SRF) in mice have learned new and unexpected facts about SRF's role in early cardiovascular development, and how a defect in this gene may be an underlying cause in human miscarriages.

8 Dec 2004

Revival of a unique and proven cancer treatment, neutron therapy

Northern Illinois University has announced plans to revive a unique and proven cancer treatment that blends advanced medical science with accelerator physics developed at Fermi National Accelerator Laboratory, a Department of Energy laboratory in Batavia, Ill.

7 Dec 2004

Zarnestra, a farnesyl transferase inhibitor, can help treat high-risk myelodysplastic syndrome patients

An oral targeted therapy gentle enough to be used by patients in their 70s or 80s is showing benefit in treating high-risk myelodysplastic syndrome (MDS), a pre-leukemic disorder that can progress to acute myelogenous leukemia (AML), according to a study presented at the annual meeting of the American Society of Hematology (ASH).

7 Dec 2004

Novel mutagenesis screen used to identify genetic suppressors of thrombosis

Researchers using a novel sensitized ENU (N-ethyl-N-nitrosourea, a carcinogen-induced animal tumor model established to grow malignant and benign tumors) mutagenesis (induction of mutation) screen in laboratory mice have developed a promising approach to genetic screening that can increase the likelihood of identifying dominant suppressors of thrombosis.

6 Dec 2004

New advances in sickle cell disease

Excruciating pain episodes, recurrent pneumonias, strokes, severe infections, chronic hemolytic anemia, and secondary pulmonary hypertension are common complications of sickle cell disease, a life-threatening inherited defect in blood that causes normally disc-shaped red blood cells to take on a sickle shape.

6 Dec 2004

Month of birth linked to risk of multiple sclerosis

In the northern hemisphere, being born in May is linked to an increased risk of developing multiple sclerosis later in life, while being born in November carries the lowest risk, finds a new study published on bmj.com today.

6 Dec 2004

New research aims to reduce deaths and ease burden on hospitals

New research by scientists at Australia's Macquarie University will investigate antibiotic resistance genes in humans in an effort to combat worldwide death rates due to infectious diseases and reduce the growing burden on our health system by decreasing patients' length of stay.

6 Dec 2004

Episome vectors offer fresh angle to gene therapy

A European research team is seeking to overcome the early setbacks suffered by the promising new field of ‘gene therapy’ by developing a revolutionary delivery technique, known as ‘episome vectors’. This breakthrough could pave the way to treating hereditary diseases by injecting the body with healthy versions of damaged genes.

6 Dec 2004

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Modern research is delving deep into the human genome to find the answers to medical mysteries and, hopefully, cures for the most deadly diseases. According to four new studies presented during the 46th Annual Meeting of the American Society of Hematology

5 Dec 2004

Researchers step closer to cure for common childhood cancer

Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of white blood cells (WBC) in the bone marrow and blood. ALL is the most common cancer occurring in children with an annual rate of approximately 30 to 40 new cases per million.

5 Dec 2004

Bcl-6 oncogene - genetic target for lymphoma treatment

Results from a pre-clinical study show that the gene designated Bcl-6 is an oncogene -- that is, one with the potential to cause a normal cell to become cancerous -- but that certain peptide inhibitors can in effect inactivate it, according to a study to be presented today during the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

As mobile phone use rises, possibility of unseen biological impact is quietly troubling

Cell biologists are of two minds about the possible biological effects of mobile phone radiation. In the mid-1990s, studies describing possible pathological effects on tissues bombarded with low-level radio frequencies (RF) were first featured in the popular press and then discredited by scientists.

4 Dec 2004

Genes News and Research

Celebrex like gene suppresses the growth of colon cancer

New approach to genomic testing identifies women with low risk of breast cancer recurrence

Study of early stage breast cancer patients identifies women at low risk of breast cancer mortality

First gene therapy for skin cancer

Using precise, radioactively labeled genetic probes, researchers study cancer gene activity from outside the body

Discovery of key immune system molecules that helps determine how effectively a person resists HIV infection

New technology will advance our understanding of role of complex sugar chains decorating the surface of cells in the body

New research is allowing biochemists to understand a key hierarchy of protein interactions that occurs in DNA

Defect in one of nature's oldest proteins may be an underlying cause in human miscarriages

Revival of a unique and proven cancer treatment, neutron therapy

Zarnestra, a farnesyl transferase inhibitor, can help treat high-risk myelodysplastic syndrome patients

Novel mutagenesis screen used to identify genetic suppressors of thrombosis

New advances in sickle cell disease

Month of birth linked to risk of multiple sclerosis

New research aims to reduce deaths and ease burden on hospitals

Episome vectors offer fresh angle to gene therapy

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Researchers step closer to cure for common childhood cancer

Bcl-6 oncogene - genetic target for lymphoma treatment

As mobile phone use rises, possibility of unseen biological impact is quietly troubling

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