Spike Protein News and Research

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Researchers design new version of protein to develop COVID-19 vaccine

Responding to a need to quickly develop billions of doses of lifesaving COVID-19 vaccines, a scientific team at The University of Texas at Austin has successfully redesigned a key protein from the coronavirus, and the modification could enable much faster and more stable production of vaccines worldwide.

24 Jul 2020

Engineered SARS-CoV-2 spike protein is more stable and can generate larger yields in the lab

A team of scientists has engineered the spike protein of the SARS-CoV-2 virus - a critical component of potential COVID-19 vaccines - to be more environmentally stable and generate larger yields in the lab.

23 Jul 2020

Study shows interferons do not induce the expression of SARS-CoV-2 cell entry receptor

In a new bioRxiv study, authors identified a isoform of ACE2 (designated as deltaACE2 or dACE2) receptor, shown to be induced in various human cell types.

23 Jul 2020

New article sheds light on challenges faced by vaccine developers

With the global pandemic still in full swing, scientists are working to develop a vaccine in record time. While everyone wants an effective vaccine, they don't all agree on how to get there and what "effective" really means.

23 Jul 2020

Malaria drug does not prevent infection of human lung cells with novel coronavirus

More than 600,000 people worldwide have fallen victim to the lung disease COVID-19 so far, which is caused by the SARS coronavirus-2 (SARS-CoV-2).

22 Jul 2020

Study shows chloroquine does not prevent SARS-CoV-2

More than 600,000 people worldwide have fallen victim to the lung disease COVID-19 so far, which is caused by the SARS coronavirus-2 (SARS-CoV-2).

22 Jul 2020

Scientists isolate potent SARS-CoV-2 neutralizing antibodies from COVID-19 patients

Researchers at Columbia University Irving Medical Center have isolated antibodies from several COVID-19 patients that, to date, are among the most potent in neutralizing the SARS-CoV-2 virus.

22 Jul 2020

Scientists report two new cryo-EM structures of SARS-Cov-2 spike protein

Scientists report two new cryo-EM structures representing the pre- and postfusion conformations of the full-length SARS-CoV-2 spike (S) protein, an essential viral component responsible for host cell entry and the spread of infection.

22 Jul 2020

Study captures unexpected features of SARS-Cov-2 spike protein

The rod-like spike proteins on the surface of SARS CoV-2 are the tip of the spear of the COVID-19 pandemic.

22 Jul 2020

Lab-made virus infects cells, interacts with antibodies just like SARS-CoV-2

Airborne and potentially deadly, the virus that causes COVID-19 can only be studied safely under high-level biosafety conditions.

21 Jul 2020

New tools developed to test the ability of anti-coronavirus antibodies

Researchers at The Rockefeller University in New York have developed new tools to rapidly test the ability of antibodies to neutralize SARS-CoV-2, the novel coronavirus responsible for the COVID-19 pandemic.

21 Jul 2020

Antibody profile and estimated seroprevalence in COVID-19 infection

A new Swedish study published on the preprint server medRxiv in July 2020 describes the results of using highly sensitive and specific anti-spike antibody tests in a cohort of patients with COVID-19 over a range of disease severity.

21 Jul 2020

Analysis of the SARS-CoV-2 proteome via visual tools

Now, a new study published on the preprint server bioRxiv* in July 2020 shows how this can be advanced at a greater speed by combining experimental results with homology models obtained by high-throughput pipelines. This will help produce new hypotheses that will show novel druggable targets for effective drug development.

21 Jul 2020

New nanoparticle vaccine for SARS-CoV-2 shows protective traits in preclinical study

A new nanoparticle vaccine for SARS-CoV-2, the virus that causes COVID-19, has shown hints of protection and immunity in a preclinical study, safely eliciting the production of antibodies and antiviral T cell responses in mice and pigtail macaques.

20 Jul 2020

Involvement of nicotine receptors in COVID-19

Researchers from the University of Bristol, Oxford Brookes University and the University of California San Diego neatly demonstrated how the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits high affinity for nicotinic acetylcholine receptors (nAChRs), with significant implications for coronavirus disease (COVID-19) pathology and infectivity. Their findings are published on the bioRxiv* preprint server.

20 Jul 2020

UC Davis Health evaluates new antibody cocktail as a possible treatment for COVID-19

Timothy Albertson, chair of internal medicine and specialist in pulmonary and critical care, is leading efforts at UC Davis Health to test a new antibody cocktail (REGN-COV2) as a prevention and treatment for COVID-19.

20 Jul 2020

China's Ad5 vectored COVID-19 vaccine safe and induces immune response

A phase 2 trial of an Ad5 vectored COVID-19 vaccine candidate, conducted in China, has found that the vaccine is safe and induces an immune response, according to new research published in The Lancet.

20 Jul 2020

Oxford University and AstraZeneca vaccine against SARS-CoV-2 safe and induces immune response

Promising early stage results from a phase 1/2 clinical trial of the UK's vaccine candidate against SARS-CoV-2 (the virus that causes COVID-19) are published today in The Lancet.

20 Jul 2020

Examining cardiovascular injuries in patients who recovered from COVID-9 infection

The coronavirus disease is wreaking havoc on the health of communities throughout the world and may have lasting cardiac effects on those who have recovered from the virus.

19 Jul 2020

Researchers are producing COVID-19 spike proteins to prevent future infections

On July 1, the Texas A&M Engineering Experiment Station's National Center for Therapeutics Manufacturing received funding from the National Institute for Innovation in Manufacturing Biopharmaceuticals to help find a way to prevent the SARS-CoV-2 virus from binding to cells, protecting people from future infections.

19 Jul 2020

Spike Protein News and Research

Researchers design new version of protein to develop COVID-19 vaccine

Engineered SARS-CoV-2 spike protein is more stable and can generate larger yields in the lab

Study shows interferons do not induce the expression of SARS-CoV-2 cell entry receptor

New article sheds light on challenges faced by vaccine developers

Malaria drug does not prevent infection of human lung cells with novel coronavirus

Study shows chloroquine does not prevent SARS-CoV-2

Scientists isolate potent SARS-CoV-2 neutralizing antibodies from COVID-19 patients

Scientists report two new cryo-EM structures of SARS-Cov-2 spike protein

Study captures unexpected features of SARS-Cov-2 spike protein

Lab-made virus infects cells, interacts with antibodies just like SARS-CoV-2

New tools developed to test the ability of anti-coronavirus antibodies

Antibody profile and estimated seroprevalence in COVID-19 infection

Analysis of the SARS-CoV-2 proteome via visual tools

New nanoparticle vaccine for SARS-CoV-2 shows protective traits in preclinical study

Involvement of nicotine receptors in COVID-19

UC Davis Health evaluates new antibody cocktail as a possible treatment for COVID-19

China's Ad5 vectored COVID-19 vaccine safe and induces immune response

Oxford University and AstraZeneca vaccine against SARS-CoV-2 safe and induces immune response

Examining cardiovascular injuries in patients who recovered from COVID-9 infection

Researchers are producing COVID-19 spike proteins to prevent future infections

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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