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Researchers develop highly specific apoptosis assay for pharmacodynamic analyses of tumor specimens

Existing microscopy-based methods of detecting apoptosis, such as TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labeling), have limited quantitative capabilities due to insufficient signal-to-noise ratios.

19 Apr 2018

Genome editing identifies neural circuit behind leptin’s anti-obesity and anti-diabetes effects

Revealing surprising answers to a long-standing enigma about the brain target of the anti-obesity hormone leptin, neuroscientists at Tufts University School of Medicine have used CRISPR genome editing to identify a neural circuit in the hypothalamus as the primary mechanism in mediating leptin's anti-obesity and anti-diabetes effects and have identified two distinct mechanisms underlying leptin's inhibition of appetite.

19 Apr 2018

The Swedish Childhood Cancer Foundation awards grant to KI researchers

Ten researchers at Karolinska Institutet have been awarded grants in the Swedish Childhood Cancer Foundation's latest call for funding, during which approximately SEK 62 million was allocated.

19 Apr 2018

New insight may allow researchers to design drugs that improve immune responses to vaccines

Memory T cells are a critical element of our immune system's historical archive. To prevent repeat infections, these cells retain a record of germs they've fought before.

19 Apr 2018

Direct electrical current can be delivered to nerves for blocking pain signals

Using computer models and laboratory rats, Johns Hopkins researchers have demonstrated that "direct electrical current" can be delivered to nerves preferentially, blocking pain signals while leaving other sensations undisturbed.

18 Apr 2018

Novel stem cell therapy may transform current paradigms for treating heart failure patients

Clinical trial planning is underway at MedStar Heart & Vascular Institute to determine whether a novel stem cell therapy will improve heart function for patients with heart failure.

18 Apr 2018

UT Southwestern scientists discover protein linked to metastatic breast cancer

Researchers at UT Southwestern Medical Center have identified a protein that is strongly associated with metastatic breast cancer and that could be a target for future therapies.

18 Apr 2018

Compound derived from immune cells treats psoriasis in mice

A compound derived from immune cells treats psoriasis in mice and holds promise for other autoimmune diseases, according to a new study from Washington University School of Medicine in St. Louis.

18 Apr 2018

'Gut-on-a-chip' model recreates intestinal matrix critical for nutrient absorption

The difficulties of conducting research on the human gut are substantial: the presence of trillions of bacterial cells interacting with human cells and each other, constant environmental changes every time food is consumed and zero chance of conducting trials that control for all those moving parts.

18 Apr 2018

Novel method enables fast and noninvasive assessment of tumor status

How aggressive is a tumor? To measure the tumor status without taking tissue samples, Italian researchers have developed a method based on magnetic resonance imaging (MRI) of whole body parts.

18 Apr 2018

Researchers discover unique protein in malaria parasite that could be new drug target

Over a thousand people die from malaria every day. The disease is caused by a single-cell parasite (protozoan) that is transmitted by mosquitoes. Anti-malaria efforts currently focus on effective diagnostics, mosquito nets, insecticides and drugs.

18 Apr 2018

Study examines effectiveness of caregiver education about sickle cell trait

Despite universal newborn screening that detects the presence of sickle cell trait (SCT), only 16 percent of Americans with SCT know their status. To address this issue, in Ohio, in-person education is offered to caregivers of referred infants with SCT.

18 Apr 2018

Researchers use 'top-down proteomics' strategy to get new insights into cancer

When a RAS gene operates normally, it acts as an on/off switch for cell signaling to control cell proliferation. But when the gene mutates, the switch jams into the "on" position, allowing cells to proliferate uncontrollably.

18 Apr 2018

Study sheds light on how the HSC niche is maintained

Researchers have identified an important cellular protein involved in the maintenance of bone marrow cavities and the hematopoietic stem cell (HSC) niche

18 Apr 2018

Bio-Techne expands automation capabilities of popular RNAscope ISH technology

Bio-Techne has expanded the automation capabilities of its popular Advanced Cell Diagnostics -branded RNAscope in situ hybridization technology with the launch of several new and updated assays.

From Bio-Techne 18 Apr 2018

Study finds muscle complications among active young adults with Type 1 diabetes

A new study from McMaster and York universities has found that poor muscle health may be a complication of Type 1 diabetes, even among active twenty-somethings.

18 Apr 2018

Researchers clarify immune response for patients with breast cancer brain metastases

Once it has begun to spread in the body, approximately half of patients with an aggressive breast cancer type will develop cancer in the brain. Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center want to improve treatment for patients with breast cancer brain metastases, but using the body's existing defenses - the immune system.

18 Apr 2018

New study maps links between 625 genes and different chemotherapy treatments

Despite the great successes of targeted cancer drugs and the promise of novel immunotherapies, the vast majority of people diagnosed with cancer are still first treated with chemotherapy. Now a new study by UCSF researchers using techniques drawn from computational biology could make it much easier for physicians to use the genetic profile of a patient's tumor to pick the chemotherapy treatment with the fewest side effects and best chance of success.

18 Apr 2018

Children with autism have gastrointestinal and immune system deregulation, research finds

Researchers at the UC Davis MIND Institute have found that children with autism spectrum disorder have reduced immune system regulation, as well as shifts in their gut microbiota.

17 Apr 2018

Roswell Park researchers identify driver of cancer-promoting metabolic changes

Roswell Park Comprehensive Cancer Center researchers have identified a potential key player promoting cancer progression through changes in the cell environment that are conducive to metastasis.

17 Apr 2018

B Cell News and Research

Researchers develop highly specific apoptosis assay for pharmacodynamic analyses of tumor specimens

Genome editing identifies neural circuit behind leptin’s anti-obesity and anti-diabetes effects

The Swedish Childhood Cancer Foundation awards grant to KI researchers

New insight may allow researchers to design drugs that improve immune responses to vaccines

Direct electrical current can be delivered to nerves for blocking pain signals

Novel stem cell therapy may transform current paradigms for treating heart failure patients

UT Southwestern scientists discover protein linked to metastatic breast cancer

Compound derived from immune cells treats psoriasis in mice

'Gut-on-a-chip' model recreates intestinal matrix critical for nutrient absorption

Novel method enables fast and noninvasive assessment of tumor status

Researchers discover unique protein in malaria parasite that could be new drug target

Study examines effectiveness of caregiver education about sickle cell trait

Researchers use 'top-down proteomics' strategy to get new insights into cancer

Study sheds light on how the HSC niche is maintained

Bio-Techne expands automation capabilities of popular RNAscope ISH technology

Study finds muscle complications among active young adults with Type 1 diabetes

Researchers clarify immune response for patients with breast cancer brain metastases

New study maps links between 625 genes and different chemotherapy treatments

Children with autism have gastrointestinal and immune system deregulation, research finds

Roswell Park researchers identify driver of cancer-promoting metabolic changes

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